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The Protective Effects of Long-Term Oral Administration of Marine Collagen Hydrolysate from Chum Salmon on Collagen Matrix Homeostasis in the Chronological Aged Skin of Sprague-Dawley Male Rats
Liang, Jiang1; Pei, Xinrong2; Zhang, Zhaofeng1; Wang, Nan1; Wang, Junbo1; Li, Yong1
关键词chronological aging collagen hydrolysate collagen matrix skin Sprague-Dawley rat
刊名JOURNAL OF FOOD SCIENCE
2010-10-01
DOI10.1111/j.1750-3841.2010.01782.x
75期:8页:H230-H238
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Food Science & Technology
研究领域[WOS]Food Science & Technology
关键词[WOS]BETA SIGNAL-TRANSDUCTION ; PHOTOAGED HUMAN SKIN ; TGF-BETA ; OXIDATIVE STRESS ; IN-VIVO ; METALLOPROTEINASES ; GELATIN ; FIBROBLASTS ; PEPTIDES ; MICE
英文摘要

To investigate the long-term effects of marine collagen hydrolysate (MCH) from Chum Salmon skin on the aberrant collagen matrix homeostasis in chronological aged skin, Sprague-Dawley male rats of 4-wk-old were orally administrated with MCH at the diet concentrations of 2.25% and 4.5% for 24 mo. Histological and biochemical analysis revealed that MCH had the potential to inhibit the collagen loss and collagen fragmentation in chronological aged skin. Based on immunohistochemistry and western blot analysis, collagen type I and III protein expression levels in MCH-treated groups significantly increased as compared with the aged control group. Furthermore, quantitative real-time polymerase chain reaction and western blot analysis showed MCH was able to increase the expressions of procollagen type I and III mRNA (COL1A2 and COL3A1) through activating Smad signaling pathway with up-regulated TGF-beta RII (T beta RII) expression level. Meanwhile, MCH was shown to inhibit the age-related increased collagen degradation through attenuating MMP-1 expression and increasing tissue inhibitor of metalloproteinases-1 expression in a dose-dependent manner. Moreover, MCH could alleviate the oxidative stress in chronological aged skin, which was revealed from the data of superoxide dismutase activity and the thiobarbituric acid reactive substances level in skin homogenates. Therefore, MCH was demonstrated to have the protective effects on chronological skin aging due to the influence on collagen matrix homeostasis. And the antioxidative property of MCH might play an important role in the process.

语种英语
WOS记录号WOS:000282878200007
项目编号2006BAD27B08
资助机构Ministry of Science and Technology of the People&prime ; s Republic of China
引用统计
被引频次:26[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/67116
专题北京大学公共卫生学院
北京大学公共卫生学院_营养与食品卫生学系
北京大学公共卫生学院_公共卫生学院
作者单位1.Peking Univ, Dept Nutr & Food Hyg, Sch Publ Hlth, Beijing 100191, Peoples R China
2.Capital Med Univ, Ctr Food & Drug Safety Evaluat, Beijing 100069, Peoples R China
推荐引用方式
GB/T 7714
Liang, Jiang,Pei, Xinrong,Zhang, Zhaofeng,et al. The Protective Effects of Long-Term Oral Administration of Marine Collagen Hydrolysate from Chum Salmon on Collagen Matrix Homeostasis in the Chronological Aged Skin of Sprague-Dawley Male Rats[J]. JOURNAL OF FOOD SCIENCE,2010,75(8):H230-H238.
APA Liang, Jiang,Pei, Xinrong,Zhang, Zhaofeng,Wang, Nan,Wang, Junbo,&Li, Yong.(2010).The Protective Effects of Long-Term Oral Administration of Marine Collagen Hydrolysate from Chum Salmon on Collagen Matrix Homeostasis in the Chronological Aged Skin of Sprague-Dawley Male Rats.JOURNAL OF FOOD SCIENCE,75(8),H230-H238.
MLA Liang, Jiang,et al."The Protective Effects of Long-Term Oral Administration of Marine Collagen Hydrolysate from Chum Salmon on Collagen Matrix Homeostasis in the Chronological Aged Skin of Sprague-Dawley Male Rats".JOURNAL OF FOOD SCIENCE 75.8(2010):H230-H238.
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