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学科主题: 公共卫生
题名:
The Protective Effects of Long-Term Oral Administration of Marine Collagen Hydrolysate from Chum Salmon on Collagen Matrix Homeostasis in the Chronological Aged Skin of Sprague-Dawley Male Rats
作者: Liang, Jiang1; Pei, Xinrong2; Zhang, Zhaofeng1; Wang, Nan1; Wang, Junbo1; Li, Yong1
关键词: chronological aging ; collagen hydrolysate ; collagen matrix ; skin ; Sprague-Dawley rat
刊名: JOURNAL OF FOOD SCIENCE
发表日期: 2010-10-01
DOI: 10.1111/j.1750-3841.2010.01782.x
卷: 75, 期:8, 页:H230-H238
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Food Science & Technology
研究领域[WOS]: Food Science & Technology
关键词[WOS]: BETA SIGNAL-TRANSDUCTION ; PHOTOAGED HUMAN SKIN ; TGF-BETA ; OXIDATIVE STRESS ; IN-VIVO ; METALLOPROTEINASES ; GELATIN ; FIBROBLASTS ; PEPTIDES ; MICE
英文摘要:

To investigate the long-term effects of marine collagen hydrolysate (MCH) from Chum Salmon skin on the aberrant collagen matrix homeostasis in chronological aged skin, Sprague-Dawley male rats of 4-wk-old were orally administrated with MCH at the diet concentrations of 2.25% and 4.5% for 24 mo. Histological and biochemical analysis revealed that MCH had the potential to inhibit the collagen loss and collagen fragmentation in chronological aged skin. Based on immunohistochemistry and western blot analysis, collagen type I and III protein expression levels in MCH-treated groups significantly increased as compared with the aged control group. Furthermore, quantitative real-time polymerase chain reaction and western blot analysis showed MCH was able to increase the expressions of procollagen type I and III mRNA (COL1A2 and COL3A1) through activating Smad signaling pathway with up-regulated TGF-beta RII (T beta RII) expression level. Meanwhile, MCH was shown to inhibit the age-related increased collagen degradation through attenuating MMP-1 expression and increasing tissue inhibitor of metalloproteinases-1 expression in a dose-dependent manner. Moreover, MCH could alleviate the oxidative stress in chronological aged skin, which was revealed from the data of superoxide dismutase activity and the thiobarbituric acid reactive substances level in skin homogenates. Therefore, MCH was demonstrated to have the protective effects on chronological skin aging due to the influence on collagen matrix homeostasis. And the antioxidative property of MCH might play an important role in the process.

语种: 英语
所属项目编号: 2006BAD27B08
项目资助者: Ministry of Science and Technology of the People&prime ; s Republic of China
WOS记录号: WOS:000282878200007
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/67116
Appears in Collections:北京大学公共卫生学院_期刊论文

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作者单位: 1.Peking Univ, Dept Nutr & Food Hyg, Sch Publ Hlth, Beijing 100191, Peoples R China
2.Capital Med Univ, Ctr Food & Drug Safety Evaluat, Beijing 100069, Peoples R China

Recommended Citation:
Liang, Jiang,Pei, Xinrong,Zhang, Zhaofeng,et al. The Protective Effects of Long-Term Oral Administration of Marine Collagen Hydrolysate from Chum Salmon on Collagen Matrix Homeostasis in the Chronological Aged Skin of Sprague-Dawley Male Rats[J]. JOURNAL OF FOOD SCIENCE,2010,75(8):H230-H238.
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