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Osteogenic differentiation of MC3T3-E1 cells on poly(L-lactide)/Fe3O4 nanofibers with static magnetic field exposure
Cai, Qing1,2; Shi, Yuzhou2; Shan, Dingying2; Jia, Wenkai2; Duan, Shun2; Deng, Xuliang3; Yang, Xiaoping1,2
关键词Magnetic nanofibers Osteogenic differentiation Static magnetic field Moderate-intensity
刊名MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
2015-10-01
DOI10.1016/j.msec.2015.05.002
55页:166-173
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Materials Science, Biomaterials
资助者National Basic Research Program of China ; National Key Technology Research and Development Program of China ; National Natural Science Foundation of China ; Program for New Century Excellent Talents in University ; National Basic Research Program of China ; National Key Technology Research and Development Program of China ; National Natural Science Foundation of China ; Program for New Century Excellent Talents in University
研究领域[WOS]Materials Science
关键词[WOS]FE3O4 NANOPARTICLES ; BONE ; PROLIFERATION ; BIOMINERALIZATION
英文摘要

Proliferation and differentiation of bone-related cells are modulated by many factors such as scaffold design, growth factor, dynamic culture system, and physical simulation. Nanofibrous structure and moderate-intensity (1 mT-1 T) static magnetic field (SMF) have been identified as capable of stimulating proliferation and differentiation of osteoblasts. Herein, magnetic nanofibers were prepared by electrospinning mixture solutions of poly(L-lactide) (PLLA) and ferromagnetic Fe3O4 nanoparticles (NPs). The PLLA/Fe3O4 composite nanofibers demonstrated homogeneous dispersion of Fe3O4 NPs, and their magnetism depended on the contents of Fe3O4 NPs. SMF of 100 mT was applied in the culture of MC3T3-E1 osteoblasts on pure PLLA and PLLA/Fe3O4 composite nanofibers for the purpose of studying the effect of SMF on osteogenic differentiation of osteoblastic cells on magnetic nanofibrous scaffolds. On non-magnetic PLIA nanofibers, the application of external SMF could enhance the proliferation and osteogenic differentiation of MOT3-E1 cells. In comparison with pure PLLA nanofibers, the incorporation of Fe3O4 NPs could also promote the proliferation and osteogenic differentiation of MC3T3-E1 cells in the absence or presence of external SMF. The marriage of magnetic nanofibers and external SMF was found most effective in accelerating every aspect of biological behaviors of MC3T3-E1 osteoblasts. The findings demonstrated that the magnetic feature of substrate and microenvironment were applicable ways in regulating osteogenesis in bone tissue engineering. (C) 2015 Elsevier B.V. All rights reserved.

语种英语
所属项目编号2012CB933904 ; 2012BAI07B08 ; 51473016 ; NCET-11-0556
资助者National Basic Research Program of China ; National Key Technology Research and Development Program of China ; National Natural Science Foundation of China ; Program for New Century Excellent Talents in University ; National Basic Research Program of China ; National Key Technology Research and Development Program of China ; National Natural Science Foundation of China ; Program for New Century Excellent Talents in University
WOS记录号WOS:000358809500020
引用统计
被引频次:7[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/67121
专题北京大学口腔医学院
作者单位1.Beijing Univ Chem Technol, State Key Lab Organ Inorgan Composites, Beijing 100029, Peoples R China
2.Beijing Univ Chem Technol, Beijing Lab Biomed Mat, Beijing 100029, Peoples R China
3.Peking Univ, Sch & Hosp Stomatol, Dept Geriatr Dent, Beijing 100081, Peoples R China
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GB/T 7714
Cai, Qing,Shi, Yuzhou,Shan, Dingying,et al. Osteogenic differentiation of MC3T3-E1 cells on poly(L-lactide)/Fe3O4 nanofibers with static magnetic field exposure[J]. MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS,2015,55:166-173.
APA Cai, Qing.,Shi, Yuzhou.,Shan, Dingying.,Jia, Wenkai.,Duan, Shun.,...&Yang, Xiaoping.(2015).Osteogenic differentiation of MC3T3-E1 cells on poly(L-lactide)/Fe3O4 nanofibers with static magnetic field exposure.MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS,55,166-173.
MLA Cai, Qing,et al."Osteogenic differentiation of MC3T3-E1 cells on poly(L-lactide)/Fe3O4 nanofibers with static magnetic field exposure".MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS 55(2015):166-173.
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