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IR@PKUHSC  > 北京大学第一临床医学院  > 消化内科  > 期刊论文
学科主题: 临床医学
题名:
Thermosensitive Injectable Hydrogel Enhances the Antitumor Effect of Embelin in Mouse Hepatocellular Carcinoma
作者: Peng, Meiyu1,2; Xu, Shuxin3; Zhang, Yong4; Zhang, Lijuan1,2; Huang, Bingqing1; Fu, Shuyu1; Xue, Zhenyi1,2; Da, Yurong1,2; Dai, Yun5; Qiao, Liang6; Dong, Anjie3; Zhang, Rongxin1,2; Meng, Wenbo7
关键词: embelin ; cancer ; controlled release ; delivery ; hydrogels ; injectable ; thermal gels
刊名: JOURNAL OF PHARMACEUTICAL SCIENCES
发表日期: 2014-03-01
DOI: 10.1002/jps.23885
卷: 103, 期:3, 页:965-973
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Chemistry, Medicinal ; Chemistry, Multidisciplinary ; Pharmacology & Pharmacy
研究领域[WOS]: Pharmacology & Pharmacy ; Chemistry
关键词[WOS]: ORAL INSULIN DELIVERY ; CONTROLLED-RELEASE FORMULATION ; BREAST-CANCER CELLS ; TRIBLOCK COPOLYMERS ; DRUG-RELEASE ; PCL-PEG ; NANOPARTICLES ; PACLITAXEL ; LIVER ; MANAGEMENT
英文摘要:

Embelin, an active ingredient of traditional herbal medicine, is used to treat many diseases such as cancer. However, embelin is hydrophobic and insoluble in water, which makes it unsuitable for in vivo applications. In this study, we constructed an embelin-loaded thermosensitive injectable hydrogel system that we named Embelin/PECTgel based on the amphiphilic triblock copolymer of poly (epsilon-caprolactone-co-1,4,8-trioxa[4.6]spiro-9-undecanone)-poly (ethylene glycol)-poly (epsilon-caprolactone-co-1,4,8-trioxa[4.6]spiro-9-undecanone) (PECT). The cytotoxicity and the antitumor effects of Embelin/PECTgel on mouse hepatic cancers were investigated in vitro and in vivo. Results indicated that embelin was formulated in PECT hydrogel and could be continuously released from Embelin/PECTgel, showing a higher cytotoxicity for H22 cells in vitro compared with free embelin. The aqueous solution of Embelin/PECTgel transformed into gel at the injection site within seconds, which later eroded and degraded over time in vivo. A single local peritumoral injection of Embelin/PECTgel in liver at a low dosage of 0.5 mg per mouse exhibited a significant antitumor effect, which was comparable to the antitumor effect of the embelin solution treatment at a total dose of 6 mg per mouse in mouse hepatic cancer. Embelin/PECTgel, as a drug delivery system in liver, represents a novel therapeutic drug candidate for the clinical treatment of advanced hepatocellular carcinoma. (c) 2014 Wiley Periodicals, Inc.

语种: 英语
所属项目编号: 2012CB932503 ; 2011CB933100 ; 91029705 ; 81172864 ; 81272317 ; 81072019 ; 81371667
项目资助者: Ministry of Science and Technology of China ; National Natural Science Foundation of China
WOS记录号: WOS:000331392900020
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/67127
Appears in Collections:北京大学第一临床医学院_消化内科_期刊论文

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作者单位: 1.Tianjin Med Univ, Res Ctr Basic Med Sci, Key Lab Immune Microenvironm & Dis, Lab Immunol & Inflammat,Minist Educ China, Tianjin, Peoples R China
2.Tianjin Med Univ, Tianjin Key Lab Cellular & Mol Immunol, Key Lab Immune Microenvironm & Dis, Dept Immunol,Basic Med Coll,Minist Educ China, Tianjin, Peoples R China
3.Tianjin Univ, Sch Chem Engn & Technol, Key Lab Syst Bioengn, Minist Educ China, Tianjin 300072, Peoples R China
4.Second Peoples Hosp Lanzhou, Dept Gen Surg, Lanzhou, Gansu, Peoples R China
5.Peking Univ, Dept Gastroenterol, Hosp 1, Beijing 100871, Peoples R China
6.Univ Sydney, Westmead Hosp, Western Clin Sch, Storr Liver Unit,Westmead Millennium Inst, Westmead, NSW 2145, Australia
7.Lanzhou Univ, Canc Ctr Clin Med Coll, Hepatopancreatobiliary Surg Inst Gansu, Hosp 1, Lanzhou 730000, Gansu, Peoples R China

Recommended Citation:
Peng, Meiyu,Xu, Shuxin,Zhang, Yong,et al. Thermosensitive Injectable Hydrogel Enhances the Antitumor Effect of Embelin in Mouse Hepatocellular Carcinoma[J]. JOURNAL OF PHARMACEUTICAL SCIENCES,2014,103(3):965-973.
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