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学科主题临床医学
Thermosensitive Injectable Hydrogel Enhances the Antitumor Effect of Embelin in Mouse Hepatocellular Carcinoma
Peng, Meiyu1,2; Xu, Shuxin3; Zhang, Yong4; Zhang, Lijuan1,2; Huang, Bingqing1; Fu, Shuyu1; Xue, Zhenyi1,2; Da, Yurong1,2; Dai, Yun5; Qiao, Liang6; Dong, Anjie3; Zhang, Rongxin1,2; Meng, Wenbo7
关键词embelin cancer controlled release delivery hydrogels injectable thermal gels
刊名JOURNAL OF PHARMACEUTICAL SCIENCES
2014-03-01
DOI10.1002/jps.23885
103期:3页:965-973
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Chemistry, Medicinal ; Chemistry, Multidisciplinary ; Pharmacology & Pharmacy
研究领域[WOS]Pharmacology & Pharmacy ; Chemistry
关键词[WOS]ORAL INSULIN DELIVERY ; CONTROLLED-RELEASE FORMULATION ; BREAST-CANCER CELLS ; TRIBLOCK COPOLYMERS ; DRUG-RELEASE ; PCL-PEG ; NANOPARTICLES ; PACLITAXEL ; LIVER ; MANAGEMENT
英文摘要

Embelin, an active ingredient of traditional herbal medicine, is used to treat many diseases such as cancer. However, embelin is hydrophobic and insoluble in water, which makes it unsuitable for in vivo applications. In this study, we constructed an embelin-loaded thermosensitive injectable hydrogel system that we named Embelin/PECTgel based on the amphiphilic triblock copolymer of poly (epsilon-caprolactone-co-1,4,8-trioxa[4.6]spiro-9-undecanone)-poly (ethylene glycol)-poly (epsilon-caprolactone-co-1,4,8-trioxa[4.6]spiro-9-undecanone) (PECT). The cytotoxicity and the antitumor effects of Embelin/PECTgel on mouse hepatic cancers were investigated in vitro and in vivo. Results indicated that embelin was formulated in PECT hydrogel and could be continuously released from Embelin/PECTgel, showing a higher cytotoxicity for H22 cells in vitro compared with free embelin. The aqueous solution of Embelin/PECTgel transformed into gel at the injection site within seconds, which later eroded and degraded over time in vivo. A single local peritumoral injection of Embelin/PECTgel in liver at a low dosage of 0.5 mg per mouse exhibited a significant antitumor effect, which was comparable to the antitumor effect of the embelin solution treatment at a total dose of 6 mg per mouse in mouse hepatic cancer. Embelin/PECTgel, as a drug delivery system in liver, represents a novel therapeutic drug candidate for the clinical treatment of advanced hepatocellular carcinoma. (c) 2014 Wiley Periodicals, Inc.

语种英语
WOS记录号WOS:000331392900020
项目编号2012CB932503 ; 2011CB933100 ; 91029705 ; 81172864 ; 81272317 ; 81072019 ; 81371667
资助机构Ministry of Science and Technology of China ; National Natural Science Foundation of China
引用统计
被引频次:7[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/67127
专题北京大学第一临床医学院_消化科
作者单位1.Tianjin Med Univ, Res Ctr Basic Med Sci, Key Lab Immune Microenvironm & Dis, Lab Immunol & Inflammat,Minist Educ China, Tianjin, Peoples R China
2.Tianjin Med Univ, Tianjin Key Lab Cellular & Mol Immunol, Key Lab Immune Microenvironm & Dis, Dept Immunol,Basic Med Coll,Minist Educ China, Tianjin, Peoples R China
3.Tianjin Univ, Sch Chem Engn & Technol, Key Lab Syst Bioengn, Minist Educ China, Tianjin 300072, Peoples R China
4.Second Peoples Hosp Lanzhou, Dept Gen Surg, Lanzhou, Gansu, Peoples R China
5.Peking Univ, Dept Gastroenterol, Hosp 1, Beijing 100871, Peoples R China
6.Univ Sydney, Westmead Hosp, Western Clin Sch, Storr Liver Unit,Westmead Millennium Inst, Westmead, NSW 2145, Australia
7.Lanzhou Univ, Canc Ctr Clin Med Coll, Hepatopancreatobiliary Surg Inst Gansu, Hosp 1, Lanzhou 730000, Gansu, Peoples R China
推荐引用方式
GB/T 7714
Peng, Meiyu,Xu, Shuxin,Zhang, Yong,et al. Thermosensitive Injectable Hydrogel Enhances the Antitumor Effect of Embelin in Mouse Hepatocellular Carcinoma[J]. JOURNAL OF PHARMACEUTICAL SCIENCES,2014,103(3):965-973.
APA Peng, Meiyu.,Xu, Shuxin.,Zhang, Yong.,Zhang, Lijuan.,Huang, Bingqing.,...&Meng, Wenbo.(2014).Thermosensitive Injectable Hydrogel Enhances the Antitumor Effect of Embelin in Mouse Hepatocellular Carcinoma.JOURNAL OF PHARMACEUTICAL SCIENCES,103(3),965-973.
MLA Peng, Meiyu,et al."Thermosensitive Injectable Hydrogel Enhances the Antitumor Effect of Embelin in Mouse Hepatocellular Carcinoma".JOURNAL OF PHARMACEUTICAL SCIENCES 103.3(2014):965-973.
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