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MALAT-1 interacts with hnRNP C in cell cycle regulation
Yang, Feng; Yi, Fan; Han, Xiaorui; Du, Quan1; Liang, Zicai
关键词MALAT-1 Long non-coding RNA Cell cycle hnRNP C
刊名FEBS LETTERS
2013-10-01
DOI10.1016/j.febslet.2013.07.048
587期:19页:3175-3181
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biochemistry & Molecular Biology ; Biophysics ; Cell Biology
资助者National Basic Research Program of China ; Beijing Natural Science Foundation ; National High-tech R&amp ; D Program of China ; Guangdong Science and Technology Department ; National Basic Research Program of China ; Beijing Natural Science Foundation ; National High-tech R&amp ; D Program of China ; Guangdong Science and Technology Department
研究领域[WOS]Biochemistry & Molecular Biology ; Biophysics ; Cell Biology
关键词[WOS]LONG NONCODING RNA ; GENE-EXPRESSION ; MOUSE DEVELOPMENT ; LUNG-CANCER ; METASTASIS ; COMPLEXES ; TRANSLATION ; COMPONENTS ; GENOME ; C1/C2
英文摘要

As a conserved non-coding RNA gene, transcripts of MALAT-1 localize predominately in the nucleus. However in G2/M cell cycle phase, MALAT-1 transcripts were surprisingly found to translocate from the nucleus into the cytoplasm. Investigation also found that in this process MALAT-1 interacts with an abundant nuclear factor, hnRNP C protein. Using a loss-of-function assay, we found that downregulation of MALAT-1 expression compromised the cytoplasmic translocation of hnRNP C in the G2/M phase and resulted in G2/M arrest. In addition to characterize the physiological interaction between MALAT-1 and hnRNP C, our study also highlights the role of MALAT-1 in cell cycle regulation. (C) 2013 Federation of European Biochemical Societies. Published by Elsevier B. V. All rights reserved.

语种英语
所属项目编号2011CBA01102 ; 5132015 ; 2012AA022501 ; 2011B090400478
资助者National Basic Research Program of China ; Beijing Natural Science Foundation ; National High-tech R&amp ; D Program of China ; Guangdong Science and Technology Department ; National Basic Research Program of China ; Beijing Natural Science Foundation ; National High-tech R&amp ; D Program of China ; Guangdong Science and Technology Department
WOS记录号WOS:000324472200003
Citation statistics
Cited Times:41[WOS]   [WOS Record]     [Related Records in WOS]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/67135
Collection北京大学药学院
作者单位1.Peking Univ, Sch Pharmaceut Sci, Inst Mol Med, Beijing 100871, Peoples R China
2.Peking Univ, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing 100871, Peoples R China
Recommended Citation
GB/T 7714
Yang, Feng,Yi, Fan,Han, Xiaorui,et al. MALAT-1 interacts with hnRNP C in cell cycle regulation[J]. FEBS LETTERS,2013,587(19):3175-3181.
APA Yang, Feng,Yi, Fan,Han, Xiaorui,Du, Quan,&Liang, Zicai.(2013).MALAT-1 interacts with hnRNP C in cell cycle regulation.FEBS LETTERS,587(19),3175-3181.
MLA Yang, Feng,et al."MALAT-1 interacts with hnRNP C in cell cycle regulation".FEBS LETTERS 587.19(2013):3175-3181.
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