|A large randomised controlled intervention trial to prevent gastric cancer by eradication of Helicobacter pylori in Linqu County, China: baseline results and factors affecting the eradication|
|Pan, Kai-feng1; Zhang, Lian1; Gerhard, Markus2; Ma, Jun-ling1; Liu, Wei-dong3; Ulm, Kurt2; Wang, Jian-xi3; Zhang, Lei1; Zhang, Yang1; Bajbouj, Monther2; Zhang, Lan-fu3; Li, Ming3; Vieth, Michael2,4; Liu, Rui-yong3; Quante, Michael; Wang, Le-hua3; Suchanek, Stepan5; Zhou, Tong1; Guan, Wei-xiang1; Schmid, Roland2; Classen, Meinhard2,6; You, Wei-cheng1|
|WOS标题词||Science & Technology|
|类目[WOS]||Gastroenterology & Hepatology|
|研究领域[WOS]||Gastroenterology & Hepatology|
|关键词[WOS]||GASTROESOPHAGEAL-REFLUX DISEASE ; PLACEBO-CONTROLLED TRIAL ; QUADRUPLE THERAPY ; DUODENAL-ULCER ; HIGH-RISK ; BISMUTH BISKALCITRATE ; ANTIBIOTIC-RESISTANCE ; TREATMENT FAILURE ; TRIPLE THERAPY ; STOMACH-CANCER|
Objective To clarify the full range of benefits and adverse consequences of Helicobacter pylori eradication as a strategy for gastric cancer prevention, the community-based intervention trial was launched in Linqu County, China.
Design A total of 184 786 residents aged 25-54 years were enrolled in this trial and received C-13-urea breath test. H. pylori positive participants were assigned into two groups, either receiving a 10-day quadruple anti-H. pylori treatment or lookalike placebos together with a single dosage of omeprazole and bismuth.
Results The prevalence of H. pylori in trial participants was 57.6%. A total of 94 101 subjects completed the treatment. The overall H. pylori eradication rate was 72.9% in the active group. Gender, body mass index, history of stomach disease, baseline delta over baseline-value of C-13-urea breath test, missed medication doses, smoking and drinking were independent predictors of eradication failure. The missed doses and high baseline delta over baseline-value were important contributors in men and women (all P-trend<0.001). However, a dose-response relationship between failure rate and smoking or drinking index was found in men (all P-trend<0.001), while high body mass index (P-trend<0.001) and history of stomach disease were significant predictors in women. The treatment failure rate increased up to 48.8% (OR 2.87, 95% CI 2.24 to 3.68) in men and 39.4% (OR 2.67, 95% CI 1.61 to 4.42) in women with multiple factors combined.
Conclusions This large community-based intervention trial to eradicate H. pylori is feasible and acceptable. The findings of this trial lead to a distinct evaluation of factors influencing eradication that should be generally considered for future eradication therapies.
|项目编号||2010DFB30310 ; 2010CB529303 ; CHN 11/021|
|资助机构||Key International S& ; T Cooperation Project ; National Basic Research Program of China (973 program) ; Peking University Cancer Hospital & ; Institute, China ; International Office BMBF, DZIF German Centre for Infection Research, Munchen, Germany|
|作者单位||1.Hlth Bur Linqu Cty, Weifang, Peoples R China|
2.Klinikum Bayreuth, Inst Pathol, Bayreuth, Germany
3.Int Digest Canc Alliance, Berlin, Germany
4.Tech Univ Munich, D-80290 Munich, Germany
5.Peking Univ, Canc Hosp & Inst, Dept Canc Epidemiol, Key Lab Carcinogenesis & Translat Res,Minist Educ, Beijing 100142, Peoples R China
6.Charles Univ Prague, Mil Univ Hosp, Fac Med 1, Dept Med, Prague, Czech Republic
|Pan, Kai-feng,Zhang, Lian,Gerhard, Markus,et al. A large randomised controlled intervention trial to prevent gastric cancer by eradication of Helicobacter pylori in Linqu County, China: baseline results and factors affecting the eradication[J]. GUT,2016,65(1):9-18.|
|APA||Pan, Kai-feng.,Zhang, Lian.,Gerhard, Markus.,Ma, Jun-ling.,Liu, Wei-dong.,...&You, Wei-cheng.(2016).A large randomised controlled intervention trial to prevent gastric cancer by eradication of Helicobacter pylori in Linqu County, China: baseline results and factors affecting the eradication.GUT,65(1),9-18.|
|MLA||Pan, Kai-feng,et al."A large randomised controlled intervention trial to prevent gastric cancer by eradication of Helicobacter pylori in Linqu County, China: baseline results and factors affecting the eradication".GUT 65.1(2016):9-18.|