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学科主题临床医学
Diagnosis of small hepatic nodules detected by surveillance ultrasound in patients with cirrhosis: Comparison between contrast-enhanced ultrasound and contrast-enhanced helical computed tomography
Dai, Ying1; Chen, Min Hua1; Fan, Zhi Hui1; Yan, Kun1; Yin, Shan Shan1; Zhang, Xiao Peng2
关键词cirrhosis contrast agent contrast-enhanced helical computed tomography contrast-enhanced ultrasound hepatocellular carcinoma small nodule
刊名HEPATOLOGY RESEARCH
2008-03-01
DOI10.1111/j.1872-034X.2007.00269.x
38期:3页:281-290
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Gastroenterology & Hepatology
研究领域[WOS]Gastroenterology & Hepatology
关键词[WOS]EARLY HEPATOCELLULAR-CARCINOMA ; FOCAL LIVER-LESIONS ; DYSPLASTIC NODULES ; TRANSPLANT PATIENTS ; CT ; ACCURACY ; ULTRASONOGRAPHY ; AGENT ; US ; MICROBUBBLES
英文摘要

Aim: To investigate the diagnostic value for the diagnosis of small (1-2 cm) hepatic nodules detected by surveillance ultrasound in patients with cirrhosis using contrast-enhanced ultrasound (CEUS) compared with that of contrast-enhanced helical computed tomography (CECT).

Methods: Seventy-two liver cirrhosis patients with 103 small hepatic nodules (1-2 cm) detected by surveillance ultrasound were enrolled in the present study. All patients underwent CEUS with SonoVue as well as CECT. Nodules which appeared by contrast enhancement during the arterial phase and contrast wash-out during the late phase on CEUS or CECT were diagnosed as malignant (hepatocellular carcinoma [HCC]). Histopathology obtained from biopsy or surgery served as the gold standard.

Results: According to the above diagnostic criteria, the sensitivity (i.e. rate of correct diagnosis of HCC) was 91.1% (51/56 HCC) for CEUS and the specificity (i.e. the rate of correct exclusion of HCC) was 87.2% (41/47 regenerative nodules [RN]).Therefore, the diagnostic accuracy of CEUS was 89.3% (92/103 all nodules). Using the same diagnostic criteria, the sensitivity, specificity and accuracy of CECT were 80.4% (45/56 HCC), 97.9% (46/47 RN), and 88.4% (91/103 all nodules). Overall, there was no significant difference between CEUS and CECT in the diagnostic confidence of small hepatic nodules. Eighty-six nodules (45 HCC and 41 RN) were correctly diagnosed by both modalities and six (five HCC and one RN) were misdiagnosed by both.

Conclusion: The ability of CEUS in the characterization of small nodules (1-2 cm) detected by surveillance US in patients with liver cirrhosis is similar to that of CECT.

语种英语
WOS记录号WOS:000252809300009
引用统计
被引频次:40[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/67152
专题北京大学临床肿瘤学院_超声科
作者单位1.Peking Univ, Sch Oncol, Dept Ultrasound, Beijing 100036, Peoples R China
2.Peking Univ, Sch Oncol, Dept Radiol, Beijing 100036, Peoples R China
推荐引用方式
GB/T 7714
Dai, Ying,Chen, Min Hua,Fan, Zhi Hui,et al. Diagnosis of small hepatic nodules detected by surveillance ultrasound in patients with cirrhosis: Comparison between contrast-enhanced ultrasound and contrast-enhanced helical computed tomography[J]. HEPATOLOGY RESEARCH,2008,38(3):281-290.
APA Dai, Ying,Chen, Min Hua,Fan, Zhi Hui,Yan, Kun,Yin, Shan Shan,&Zhang, Xiao Peng.(2008).Diagnosis of small hepatic nodules detected by surveillance ultrasound in patients with cirrhosis: Comparison between contrast-enhanced ultrasound and contrast-enhanced helical computed tomography.HEPATOLOGY RESEARCH,38(3),281-290.
MLA Dai, Ying,et al."Diagnosis of small hepatic nodules detected by surveillance ultrasound in patients with cirrhosis: Comparison between contrast-enhanced ultrasound and contrast-enhanced helical computed tomography".HEPATOLOGY RESEARCH 38.3(2008):281-290.
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