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学科主题: 基础医学
题名:
Heterogeneity within medullary-type TCR alpha beta(+)CD3(+)CD4(-)CD8(+) thymocytes in normal mouse thymus
作者: Tian, T; Zhang, J; Gao, L; Qian, XP; Chen, WF
关键词: heterogeneity ; medullary-type thymocytes ; phenotypes
刊名: INTERNATIONAL IMMUNOLOGY
发表日期: 2001-03-01
卷: 13, 期:3, 页:313-320
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Immunology
研究领域[WOS]: Immunology
关键词[WOS]: T-CELL SUBSETS ; LYMPHOKINE SECRETION ; NEGATIVE SELECTION ; MATURATION ; EXPRESSION ; ANTIGEN ; CD4+ ; EMIGRATION ; EXPANSION ; DEFINES
英文摘要:

The functional maturation process of medullary-type CD4(-)CD8(+) [CD8 single-positive (SP)I thymocytes remains largely uncharacterized. We describe a phenotypic analysis of CD8 SP medullary-type thymocytes and find a remarkable heterogeneity within this thymic cell population. While mature CD8(+) T cells in the periphery are relatively homogenous (TCR alpha beta (+) CD3(+) Qa-2(+) HSA(-)3G11(-)GC10(-)CD69(-)), CD8 SP medullary-type thymocytes contain discrete subpopulations that can be identified by differential expression of several cell-surface markers. We have identified at least six discrete subpopulations in the subset of TCR alpha beta (+)CD3(+) CD8 SP cells in the thymus. According to the expressed phenotypes, a linear developmental pathway is predicted among these CD8 SP subpopulations as follows: 6C10(+)CD69(+)HSA(hi)3G11+Qa-2(-)-->6C10(-)CD69(+) HSA(hi/int)3G11(+)Qa-2(-) --> 6C10(-)CD69(-)HSA(int)3G11(+)Qa-2(-)-->6C10(-)CD69(-)HSA(lo)3G11(+)Qa-2(-)--> 6C10(-)CD69(-)HSA(-lo)/3G11-Qa-2(-) --> 6C10(-)CD69(-)HSA(-/lo)3G11(-)Qa-2(+). This study provides a framework for understanding CD8 SP T cell maturation in the thymic medulla.

语种: 英语
WOS记录号: WOS:000167293200007
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/67155
Appears in Collections:基础医学院_免疫学系_期刊论文

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作者单位: Peking Univ, Hlth Sci Ctr, Dept Immunol, Beijing 100083, Peoples R China

Recommended Citation:
Tian, T,Zhang, J,Gao, L,et al. Heterogeneity within medullary-type TCR alpha beta(+)CD3(+)CD4(-)CD8(+) thymocytes in normal mouse thymus[J]. INTERNATIONAL IMMUNOLOGY,2001,13(3):313-320.
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