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学科主题: 临床医学
题名:
The biocompatibility research of functional Schwann Cells induced from bone mesenchymal cells with chitosan conduit membrane
作者: Zhang, PX; Xu, HL; Zhang, DY; Fu, ZG; Zhang, HB; Jiang, BG
关键词: bone mesenchymal cells ; differentiation ; Schwann Cell
刊名: ARTIFICIAL CELLS BLOOD SUBSTITUTES AND BIOTECHNOLOGY
发表日期: 2006
DOI: 10.1080/10731190500430198
卷: 34, 期:1, 页:91-99
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Biotechnology & Applied Microbiology ; Engineering, Biomedical ; Materials Science, Biomaterials
研究领域[WOS]: Biotechnology & Applied Microbiology ; Engineering ; Materials Science
关键词[WOS]: MARROW STROMAL CELLS ; STEM-CELLS ; NERVE REGENERATION ; DIFFERENTIATION
英文摘要:

To explore the adhesion and proliferation characteristics of bone marrow mesenchymal cells (MSCs) to chitosan conduit membrane, MSCs were induced by a sequential composition Beta-mercaptoethanol, retinoic acid, forskolin, basic-FGF, PDGF and heregulin. Schwann Cell markers, namely S-100 and GFAP, were used to discriminate the induced MSCs′ properties by immunofluorescent staining. These results suggested that MSCs can take on Schwann cell′s phenotype in vitro and the induce MSCs were gifted with good biocompatibility to biogradable chitosan conduit membrane. The results provided the possibilities to using the induced MSCs with chitosan conduit membrane in artificial peripherial nerve fields to promote nerve regeneration.

语种: 英语
WOS记录号: WOS:000234545400007
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/67158
Appears in Collections:北京大学第二临床医学院_期刊论文

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作者单位: Peking Univ, Peoples Hosp, Dept Trauma & Orthopead, Beijing, Peoples R China

Recommended Citation:
Zhang, PX,Xu, HL,Zhang, DY,et al. The biocompatibility research of functional Schwann Cells induced from bone mesenchymal cells with chitosan conduit membrane[J]. ARTIFICIAL CELLS BLOOD SUBSTITUTES AND BIOTECHNOLOGY,2006,34(1):91-99.
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