IR@PKUHSC  > 北京大学药学院
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The antitumor efficacy of functional paclitaxel nanomicelles in treating resistant breast cancers by oral delivery
Yao, Hong-Juan1,2; Ju, Rui-Jun1,2; Wang, Xiao-Xing1,2; Zhang, Yan1,2; Li, Ruo-Jing1,2; Yu, Yang1,2; Zhang, Liang1,2; Lu, Wan-Liang1,2
关键词Functional paclitaxel nanomicelles Oral administration Transport across the intestinal barrier Multidrug resistant Breast cancer
刊名BIOMATERIALS
2011-04-01
DOI10.1016/j.biomaterials.2011.01.038
32期:12页:3285-3302
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Engineering, Biomedical ; Materials Science, Biomaterials
研究领域[WOS]Engineering ; Materials Science
关键词[WOS]HUMAN NEUROBLASTOMA-CELLS ; P-GLYCOPROTEIN ; MULTIDRUG-RESISTANCE ; IN-VITRO ; MIXED MICELLES ; VITAMIN-E ; TAXOL ; NANOPARTICLES ; PERMEABILITY ; SURFACTANTS
英文摘要

Paclitaxel has shown potent efficacy against a wide spectrum of cancers in clinical treatment. However, chemotherapy with paclitaxel has been limited due to serious allergic reactions in patients caused by cremophor EL, and multidrug resistance in many types of tumors, and the restricted permeability across the intestinal barrier. Functional paclitaxel nanomicelles were developed to overcome these obstacles. Evaluations were performed on the breast cancer MCF-7 and resistant MCF-7/Adr cells, MCF-7 and MCF-7/Adr tumor spheroids, Caco-2 cell manolayers, everted gut sacs and the xenografted resistant MCF-7/Adr cancers in nude mice. The functional paclitaxel nanomicelles were approximately of 15 nm in diameter, significantly increased the intracellular uptake of paclitaxel, and selectively accumulated into mitochondria and endoplasmic reticulum after treatment, showing strong inhibitory effect on MCF-7 and MCF-7/Adr cells. They were able to penetrate deeply into the central region of the MCF-7 and MCF-7/Adr spheroids, resulting in a significant reduction in the size of the spheroids. TEM observations showed that the intact functional paclitaxel nanomicelles were transported across the Caco-2 cell manolayer or the everted gut sac. A significant antitumor efficacy in the xenografted resistant MCF-7/Adr cancers in mice was evidenced by oral administration, which was comparable to intravenous administration. The functional paclitaxel nanomicelles would provide a strategy for oral administration of paclitaxel, increasing solubility of paclitaxel, and overcoming the multidrug resistant cancers. (C) 2011 Elsevier Ltd. All rights reserved.

语种英语
WOS记录号WOS:000288629600013
项目编号2009CB930300 ; 7091005 ; 30772664
资助机构National Key Science Research Program of China (973 program) ; Beijing Natural Science Foundation ; National Natural Science Foundation of China
引用统计
被引频次:106[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/67161
专题北京大学药学院
北京大学第二临床医学院_麻醉科
北京大学第三临床医学院_麻醉科
作者单位1.Peking Univ, Sch Pharmaceut Sci, Beijing 100191, Peoples R China
2.Peking Univ, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China
推荐引用方式
GB/T 7714
Yao, Hong-Juan,Ju, Rui-Jun,Wang, Xiao-Xing,et al. The antitumor efficacy of functional paclitaxel nanomicelles in treating resistant breast cancers by oral delivery[J]. BIOMATERIALS,2011,32(12):3285-3302.
APA Yao, Hong-Juan.,Ju, Rui-Jun.,Wang, Xiao-Xing.,Zhang, Yan.,Li, Ruo-Jing.,...&Lu, Wan-Liang.(2011).The antitumor efficacy of functional paclitaxel nanomicelles in treating resistant breast cancers by oral delivery.BIOMATERIALS,32(12),3285-3302.
MLA Yao, Hong-Juan,et al."The antitumor efficacy of functional paclitaxel nanomicelles in treating resistant breast cancers by oral delivery".BIOMATERIALS 32.12(2011):3285-3302.
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