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学科主题: 药学
题名:
The antitumor efficacy of functional paclitaxel nanomicelles in treating resistant breast cancers by oral delivery
作者: Yao, Hong-Juan1,2; Ju, Rui-Jun1,2; Wang, Xiao-Xing1,2; Zhang, Yan1,2; Li, Ruo-Jing1,2; Yu, Yang1,2; Zhang, Liang1,2; Lu, Wan-Liang1,2
关键词: Functional paclitaxel nanomicelles ; Oral administration ; Transport across the intestinal barrier ; Multidrug resistant ; Breast cancer
刊名: BIOMATERIALS
发表日期: 2011-04-01
DOI: 10.1016/j.biomaterials.2011.01.038
卷: 32, 期:12, 页:3285-3302
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Engineering, Biomedical ; Materials Science, Biomaterials
研究领域[WOS]: Engineering ; Materials Science
关键词[WOS]: HUMAN NEUROBLASTOMA-CELLS ; P-GLYCOPROTEIN ; MULTIDRUG-RESISTANCE ; IN-VITRO ; MIXED MICELLES ; VITAMIN-E ; TAXOL ; NANOPARTICLES ; PERMEABILITY ; SURFACTANTS
英文摘要:

Paclitaxel has shown potent efficacy against a wide spectrum of cancers in clinical treatment. However, chemotherapy with paclitaxel has been limited due to serious allergic reactions in patients caused by cremophor EL, and multidrug resistance in many types of tumors, and the restricted permeability across the intestinal barrier. Functional paclitaxel nanomicelles were developed to overcome these obstacles. Evaluations were performed on the breast cancer MCF-7 and resistant MCF-7/Adr cells, MCF-7 and MCF-7/Adr tumor spheroids, Caco-2 cell manolayers, everted gut sacs and the xenografted resistant MCF-7/Adr cancers in nude mice. The functional paclitaxel nanomicelles were approximately of 15 nm in diameter, significantly increased the intracellular uptake of paclitaxel, and selectively accumulated into mitochondria and endoplasmic reticulum after treatment, showing strong inhibitory effect on MCF-7 and MCF-7/Adr cells. They were able to penetrate deeply into the central region of the MCF-7 and MCF-7/Adr spheroids, resulting in a significant reduction in the size of the spheroids. TEM observations showed that the intact functional paclitaxel nanomicelles were transported across the Caco-2 cell manolayer or the everted gut sac. A significant antitumor efficacy in the xenografted resistant MCF-7/Adr cancers in mice was evidenced by oral administration, which was comparable to intravenous administration. The functional paclitaxel nanomicelles would provide a strategy for oral administration of paclitaxel, increasing solubility of paclitaxel, and overcoming the multidrug resistant cancers. (C) 2011 Elsevier Ltd. All rights reserved.

语种: 英语
所属项目编号: 2009CB930300 ; 7091005 ; 30772664
项目资助者: National Key Science Research Program of China (973 program) ; Beijing Natural Science Foundation ; National Natural Science Foundation of China
WOS记录号: WOS:000288629600013
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/67161
Appears in Collections:北京大学药学院_期刊论文

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作者单位: 1.Peking Univ, Sch Pharmaceut Sci, Beijing 100191, Peoples R China
2.Peking Univ, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China

Recommended Citation:
Yao, Hong-Juan,Ju, Rui-Jun,Wang, Xiao-Xing,et al. The antitumor efficacy of functional paclitaxel nanomicelles in treating resistant breast cancers by oral delivery[J]. BIOMATERIALS,2011,32(12):3285-3302.
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