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学科主题: 临床医学
题名:
Effective components of Panax quinquefolius and Corydalis tuber protect the myocardium by inhibiting platelet activation and improvin E e
作者: Xue, Mei1; Liu, Mei-Lin2; Zhu, Xin-Yuan2; Shi, Da-Zhuo1; Yin, Hui-Jun1
关键词: acute myocardial infarction ; Panax quinquefolius ; Corydalis tuber ; platelet activation ; hypercoagulable state
刊名: EXPERIMENTAL AND THERAPEUTIC MEDICINE
发表日期: 2015-04-01
DOI: 10.3892/etm.2015.2271
卷: 9, 期:4, 页:1477-1481
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Medicine, Research & Experimental
研究领域[WOS]: Research & Experimental Medicine
关键词[WOS]: INFLAMMATORY REACTION ; TISSUE-DAMAGE ; BLOOD-CIRCULATION ; D-DIMER ; INFARCTION ; THROMBOSIS ; MODEL ; EXPRESSION ; APOPTOSIS ; DISEASE
英文摘要:

The aim of the present study was to investigate the effects of extract of Panax quinquefolius and Corydalis tuber (EPC) on platelet activation and the hypercoagulable state in rats with acute myocardial infarction (AMI). The MI model in Wistar rats was induced by coronary artery ligation. Sham surgery was performed as a control. The surviving rats that underwent MI surgery were divided into control (administered normal saline), metoprolol (9 mg/kg) and low-, moderate- and high-dose EPC groups (0.54, 1.08 g/kg and 2.16 g/kg, respectively). Saline, metoprolol and EPC were administered by gastrogavage for two consecutive weeks. The morphological changes of the myocardium were assessed by hematoxylin and eosin and nitroblue tetrazolium staining. Serum von Willebrand factor (vWF), D-dimer (DD), platelet membrane glycoproteins IIb-IIIa (GPIIb-IIIa) and CD62P levels were assessed using enzyme-linked immunosorbent assay. EPC attenuated the pathological changes of the myocardium. High-dose EPC decreased the serum concentration of vWF when compared with control group. Moderate and high doses of EPC decreased the DD and GPIIb-IIIa levels, and the CD62P level was gradually decreased with EPC dose escalation. The results therefore demonstrated that EPC protects the myocardium by inhibiting platelet activation and improving the hypercoagulable state in a rat model of AMI.

语种: 英语
所属项目编号: 2009ZX09103-441 ; 81030063 ; 81102722 ; 81273933
项目资助者: National Science and Technology Major Project ; National Natural Science Foundation of China
WOS记录号: WOS:000351711600064
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/67172
Appears in Collections:北京大学第一临床医学院_期刊论文

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作者单位: 1.China Acad Chinese Med Sci, Xiyuan Hosp, Cardiovasc Ctr, Beijing 100091, Peoples R China
2.Peking Univ, Dept Geriatr Med, Hosp 1, Beijing 100034, Peoples R China

Recommended Citation:
Xue, Mei,Liu, Mei-Lin,Zhu, Xin-Yuan,et al. Effective components of Panax quinquefolius and Corydalis tuber protect the myocardium by inhibiting platelet activation and improving the hypercoagulable state[J]. EXPERIMENTAL AND THERAPEUTIC MEDICINE,2015,9(4):1477-1481.
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