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Levels and regional trends of persistent organochlorines and polybrominated diphenyl ethers in Asian breast milk demonstrate POPs signatures unique to individual countries
Haraguchi, Koichi1; Koizumi, Akio2; Inoue, Kayoko2; Harada, Kouji H.2; Hitomi, Toshiaki2; Minata, Mutsuko2; Tanabe, Miyako2; Kato, Yoshihisa3; Nishimura, Eri1; Yamamoto, Yoshiaki4; Watanabe, Takao5; Takenaka, Katsunobu6; Uehara, Shigeki7; Yang, Hye-Ran8; Kim, Min-Young8; Moon, Chan-Seok9; Kim, Hae-Sook10; Wang, Peiyu11; Liu, Aiping11; Hung, Nguyen Ngoc12
关键词Human milk DDTs Pesticides PCBs PBDEs Asia Exposure
刊名ENVIRONMENT INTERNATIONAL
2009-10-01
DOI10.1016/j.envint.2009.06.003
35期:7页:1072-1079
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Environmental Sciences
研究领域[WOS]Environmental Sciences & Ecology
关键词[WOS]BROMINATED FLAME RETARDANTS ; DIBENZO-P-DIOXINS ; POLYCHLORINATED-BIPHENYLS ; YANGTZE-RIVER ; CONTINUOUS SURVEILLANCE ; ACCUMULATION KINETICS ; CONTAMINATION STATUS ; SURFACE SEDIMENTS ; ARCHIVED SAMPLES ; JAPANESE MOTHERS
英文摘要

Human breast milk samples collected in 2007-2008 from four countries, Vietnam (Hanoi), China (Beijing), Korea (Seoul) and Japan (Sendai, Kyoto and Takayama), were analyzed for persistent organic pollutants (POPS) such as dichlorodiphenyltrichloroethane and its metabolites (DDTs), chlordane-related compounds (CHLs), hexachlorocyclohexanes (HCHs), hexachlorobenzene (HCB), polychlorinated biphenyls (PCBs) and polybrominated diphenyl ethers (PBDEs). Comparing with previous surveys, the present study indicates that the DDTs in breast milk from China and Vietnam had gradually decreased during the last decade, but were still 5-10 times higher than those in other nations. The ratios of p,p′-DDE/p,p′-DDT and o,p′-DDT/p,p′-DDT were higher in Beijing than in the other countries, suggesting that there is less fresh intake of commercial DDT products and a possible exposure to dicofol in China. CHL and PCB levels were relatively higher in mothers from Japan, whereas beta-HCH and HCB were more common in Chinese women. In Japan. it is suspected that mothers in the urban/coastal area (Sendai) were more continuously exposed to organochlorine pesticides (OCPs) than mothers in the rural/inland area (Takayama). In addition, OCP levels in primiparae were significantly higher than those in multiparae from Japan and Korea. These indicate that both parity and regional factors are major determinants of the levels of OCPs and PCBs in human milk. On the other hand, higher concentrations of PBDEs were observed in mothers′ milk from Korea. The congener was dominated by BDE-47 (43-54%), followed by BDE-153 (23-33%) in all regions except for Beijing where BDE-28 (23%) was relatively abundant. In Japanese breast milk, regional and parity-dependent distributions were not observed for PBDEs. Among PBDE congeners, age-dependency was observed for BDE-153, which was negatively correlated (p<0.05) to the age of mothers in Kyoto (17 participants were housewives), while it increased with age in Sendai (10 participants were clerks). No such correlation was seen for BDE-47. indicating that BDE-47 was ingested and assimilated via different kinetics or routes from BDE-153 in Japan. (C) 2009 Elsevier Ltd. All rights reserved.

语种英语
WOS记录号WOS:000270312600012
项目编号1300001 ; 19310042 ; 20404006
资助机构Japan Science and Technology Agency ; Scientific Research ; Japan Society for the Promotion of Science
引用统计
被引频次:66[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/67177
专题北京大学公共卫生学院
作者单位1.Daiichi Coll Pharmaceut Sci, Minami Ku, Fukuoka 8158511, Japan
2.Ijinkai Takeda Gen Hosp, Dept Obstet & Gynecol, Kyoto 6011495, Japan
3.Miyagi Univ Educ, Sendai, Miyagi 9800845, Japan
4.Takayama Red Cross Hosp, Dept Neurosurg, Takayama 5068550, Japan
5.Tohoku Kosai Hosp, Dept Obstet & Gynecol, Sendai, Miyagi 9800803, Japan
6.Kyung Hee Univ, Coll Nursing Sci, Seoul 130701, South Korea
7.Hanoi Med Univ, Dept Sci & Technol, Hanoi, Vietnam
8.Kyoto Univ, Grad Sch Med, Dept Hlth & Environm Sci, Kyoto 6068501, Japan
9.Tokushima Bunri Univ, Kagawa Sch Pharmaceut Sci, Kagawa 7692193, Japan
10.Seoul Metropolitan Govt, Res Inst Publ Hlth & Environm, Seoul 137734, South Korea
11.Catholic Univ Pusan, Dept Ind Hlth, Pusan 609757, South Korea
12.Peking Univ, Sch Publ Hlth, Dept Social Med & Hlth Educ, Beijing 100083, Peoples R China
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GB/T 7714
Haraguchi, Koichi,Koizumi, Akio,Inoue, Kayoko,et al. Levels and regional trends of persistent organochlorines and polybrominated diphenyl ethers in Asian breast milk demonstrate POPs signatures unique to individual countries[J]. ENVIRONMENT INTERNATIONAL,2009,35(7):1072-1079.
APA Haraguchi, Koichi.,Koizumi, Akio.,Inoue, Kayoko.,Harada, Kouji H..,Hitomi, Toshiaki.,...&Hung, Nguyen Ngoc.(2009).Levels and regional trends of persistent organochlorines and polybrominated diphenyl ethers in Asian breast milk demonstrate POPs signatures unique to individual countries.ENVIRONMENT INTERNATIONAL,35(7),1072-1079.
MLA Haraguchi, Koichi,et al."Levels and regional trends of persistent organochlorines and polybrominated diphenyl ethers in Asian breast milk demonstrate POPs signatures unique to individual countries".ENVIRONMENT INTERNATIONAL 35.7(2009):1072-1079.
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