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学科主题: 临床医学
题名:
Overexpression of Mitofusin 2 inhibited oxidized low-density lipoprotein induced vascular smooth muscle cell proliferation and reduced atherosclerotic lesion formation in rabbit
作者: Guo, Yan-hong; Chen, Kuanghueih; Gao, Wei; Li, Qian; Chen, Li; Wang, Gui-song; Tang, Jian
关键词: atherosclerosis ; Mitofusin 2 ; oxidized low-density lipoprotein ; proliferation
刊名: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
发表日期: 2007-11-16
DOI: 10.1016/j.bbrc.2007.08.191
卷: 363, 期:2, 页:411-417
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Biochemistry & Molecular Biology ; Biophysics
研究领域[WOS]: Biochemistry & Molecular Biology ; Biophysics
关键词[WOS]: IN-VITRO ; LDL ; EXPRESSION ; ACTIVATION ; VIVO
英文摘要:

Our previous studies have implies that Mitofusin 2 (Mfn2), which was progressively reduced in arteries from ApoE(-/-) mice during the development of atherosclerosis, may take part in pathogenesis of atherosclerosis. In this study, we found that overexpression of Mfn2 inhibited oxidized low-density lipoprotein or serum induced vascular smooth muscle cell proliferation by down-regulation of Akt and ERK phosphorylation. Then we investigated the in vivo role of Mfn2 on the development of atherosclerosis in rabbits using adenovirus expressing Mitofusin 2 gene (AdMfn2). By morphometric analysis we found overexpression of Mfn2 inhibited atherosclerotic lesion formation and intima/media ratio by 66.7% and 74.6%, respectively, compared with control group. These results suggest that local Mfn2 treatment suppresses the development of atherosclerosis in vivo in part by attenuating the smooth muscle cell proliferation induced by lipid deposition and vascular injury. (C) 2007 Elsevier Inc. All rights reserved.

语种: 英语
WOS记录号: WOS:000250121500029
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/67183
Appears in Collections:北京大学第三临床医学院_心血管内科_期刊论文

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作者单位: 1.Peking Univ Third Hosp, Dept Cardiol, Key Lab Mol Cardiovasc Sci, Minist Educ, Beijing 100083, Peoples R China
2.Peking Univ, Inst Cardiovasc Sci, Beijing 100083, Peoples R China

Recommended Citation:
Guo, Yan-hong,Chen, Kuanghueih,Gao, Wei,et al. Overexpression of Mitofusin 2 inhibited oxidized low-density lipoprotein induced vascular smooth muscle cell proliferation and reduced atherosclerotic lesion formation in rabbit[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,2007,363(2):411-417.
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