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Overexpression of Mitofusin 2 inhibited oxidized low-density lipoprotein induced vascular smooth muscle cell proliferation and reduced atherosclerotic lesion formation in rabbit
Guo, Yan-hong; Chen, Kuanghueih; Gao, Wei; Li, Qian; Chen, Li; Wang, Gui-song; Tang, Jian
关键词atherosclerosis Mitofusin 2 oxidized low-density lipoprotein proliferation
刊名BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
2007-11-16
DOI10.1016/j.bbrc.2007.08.191
363期:2页:411-417
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biochemistry & Molecular Biology ; Biophysics
研究领域[WOS]Biochemistry & Molecular Biology ; Biophysics
关键词[WOS]IN-VITRO ; LDL ; EXPRESSION ; ACTIVATION ; VIVO
英文摘要

Our previous studies have implies that Mitofusin 2 (Mfn2), which was progressively reduced in arteries from ApoE(-/-) mice during the development of atherosclerosis, may take part in pathogenesis of atherosclerosis. In this study, we found that overexpression of Mfn2 inhibited oxidized low-density lipoprotein or serum induced vascular smooth muscle cell proliferation by down-regulation of Akt and ERK phosphorylation. Then we investigated the in vivo role of Mfn2 on the development of atherosclerosis in rabbits using adenovirus expressing Mitofusin 2 gene (AdMfn2). By morphometric analysis we found overexpression of Mfn2 inhibited atherosclerotic lesion formation and intima/media ratio by 66.7% and 74.6%, respectively, compared with control group. These results suggest that local Mfn2 treatment suppresses the development of atherosclerosis in vivo in part by attenuating the smooth muscle cell proliferation induced by lipid deposition and vascular injury. (C) 2007 Elsevier Inc. All rights reserved.

语种英语
WOS记录号WOS:000250121500029
引用统计
被引频次:32[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/67183
专题北京大学第三临床医学院_心血管内科
作者单位1.Peking Univ Third Hosp, Dept Cardiol, Key Lab Mol Cardiovasc Sci, Minist Educ, Beijing 100083, Peoples R China
2.Peking Univ, Inst Cardiovasc Sci, Beijing 100083, Peoples R China
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GB/T 7714
Guo, Yan-hong,Chen, Kuanghueih,Gao, Wei,et al. Overexpression of Mitofusin 2 inhibited oxidized low-density lipoprotein induced vascular smooth muscle cell proliferation and reduced atherosclerotic lesion formation in rabbit[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,2007,363(2):411-417.
APA Guo, Yan-hong.,Chen, Kuanghueih.,Gao, Wei.,Li, Qian.,Chen, Li.,...&Tang, Jian.(2007).Overexpression of Mitofusin 2 inhibited oxidized low-density lipoprotein induced vascular smooth muscle cell proliferation and reduced atherosclerotic lesion formation in rabbit.BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,363(2),411-417.
MLA Guo, Yan-hong,et al."Overexpression of Mitofusin 2 inhibited oxidized low-density lipoprotein induced vascular smooth muscle cell proliferation and reduced atherosclerotic lesion formation in rabbit".BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 363.2(2007):411-417.
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