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学科主题: 临床医学
题名:
No association between Y chromosomal haplogroups and severe acne in the Han Chinese population
作者: Guo, Mei-Hua1,2; Wu, Wen-Juan1,2; Fan, Long3; Peng, Min-Sheng3,4; Yang, Jian-Kang4,5,6; Zhang, Wen3,7; Hao, Fei8; Xie, Hong-Fu9; Xiang, Lei-Hong10; Zheng, Min11; Guo, Yan-Ni12; Song, Qing-Hua13; Tu, Cai-Xia14; Zhong, Hua; Fan, Wen-Ge16; Shi, Yue-Jun17; Cao, Ping18; Feng, Lian-Yuan19; Na, Meng20; Pang, Qin21; Yang, Xiao-Yan21; Yang, Cheng21; Zou, Xi21; He, Li1,2; Zhang, Ya-Ping3,4,5,6
刊名: JOURNAL OF HUMAN GENETICS
发表日期: 2014-08-01
DOI: 10.1038/jhg.2014.53
卷: 59, 期:8, 页:475-476
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Genetics & Heredity
研究领域[WOS]: Genetics & Heredity
关键词[WOS]: DISEASE
英文摘要:

Severe acne presents sexual dimorphism in its incidence in Chinese population. It is more prevalent in males. To assess the possible Y chromosomal contribution to severe acne risk in Han Chinese males, we analyzed 2041 Y chromosomal SNPs (Y-SNPs) in 725 severe acne cases and 651 controls retrieved from our recent genome-wide association study data. After data filtering, we assigned 585 cases and 494 controls into 12 Y chromosomal haplogroups based on 307 high-confidence Y-SNPs. No statistically significant difference in the distribution of Y chromosomal haplogroup frequencies was observed between the case and control groups. Our results showed a lack of association between the incidence of severe acne and the different Y chromosomal haplogroup in the Han Chinese population.

语种: 英语
所属项目编号: 81060123 ; 81360234 ; 2011FA028 ; 2011FB175 ; 2012FB004 ; 2011-307
项目资助者: National Natural Science Foundation of China ; Yunnan Natural Science Foundation ; R&amp ; D Infrastructure and Facility Development Program of Yunnan Province ; Youth Innovation Promotion Association, Chinese Academy of Sciences
WOS记录号: WOS:000344539500011
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/67185
Appears in Collections:北京大学第三临床医学院_皮肤科_期刊论文

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作者单位: 1.Kunming Med Univ, Kunming 650032, Peoples R China
2.Inst Dermatol & Venereol Yunnan Prov, Kunming 650032, Peoples R China
3.Changshu 1 Peoples Hosp, Dept Dermatol, Changshu, Peoples R China
4.KIZ CUHK Joint Lab Bioresources & Mol Res Common, Kunming, Peoples R China
5.Chinese Acad Sci, Kunming Inst Zool, State Key Lab Genet Resources & Evolut, Kunming, Peoples R China
6.Yunnan Univ, Minist Educ, Lab Conservat & Utilizat Bioresources, Kunming, Peoples R China
7.Yunnan Univ, Minist Educ, Key Lab Microbial Resources, Kunming, Peoples R China
8.Chinese Acad Sci, Kunming Inst Zool, Key Lab Anim Models & Human Dis Mech, Kunming, Peoples R China
9.Third Mil Med Univ, Southwest Hosp, Dept Dermatol, Chongqing, Peoples R China
10.Cent S Univ, Dept Dermatol, Xiangya Hosp, Changsha, Hunan, Peoples R China
11.Fudan Univ, Huashan Hosp, Dept Dermatol, Shanghai 200433, Peoples R China
12.Zhejiang Univ, Affiliated Hosp 2, Dept Dermatol, Sch Med, Hangzhou 310003, Zhejiang, Peoples R China
13.Fujian Med Univ, Affiliated Hosp 2, Dept Dermatol, Quanzhou, Peoples R China
14.Peking Univ, Hosp 3, Dept Dermatol, Beijing 100871, Peoples R China
15.Dalian Med Univ, Hosp 2, Dept Dermatol, Dalian, Peoples R China
16.Shandong Univ, Qilu Hosp, Dept Dermatol, Jinan 250100, Peoples R China
17.Dalian Dermatosis Hosp, Dept Dermatol, Dalian, Peoples R China
18.First Peoples Hosp Yunnan Prov, Dept Dermatol, Kunming, Peoples R China
19.Yuxi Lianyuan Hosp, Yuxi, Peoples R China
20.Kaiyuan Peoples Hosp, Dept Dermatol, Kaiyuan, Peoples R China
21.Winona Dermocosmetol Ctr, Kunming, Peoples R China

Recommended Citation:
Guo, Mei-Hua,Wu, Wen-Juan,Fan, Long,et al. No association between Y chromosomal haplogroups and severe acne in the Han Chinese population[J]. JOURNAL OF HUMAN GENETICS,2014,59(8):475-476.
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