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学科主题: 临床医学
题名:
Effects of 5-hydroxytryptamine and 5-hydroxytryptamine 2A/2C agonist on the genioglossus activity and sleep apnea in rats
作者: Zhong Yi-jue; Zhang Cheng; Wang Guang-fa
关键词: serotonin ; 5-hydroxytryptamine(2A/2C) ; rat ; sleep apnea ; genioglossus
刊名: CHINESE MEDICAL JOURNAL
发表日期: 2010-08-05
DOI: 10.3760/cma.j.issn.0366-6999.2010.15.025
卷: 123, 期:15, 页:2094-2098
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Medicine, General & Internal
研究领域[WOS]: General & Internal Medicine
关键词[WOS]: HYPOGLOSSAL MOTOR NUCLEUS ; SEROTONIN ; MOTONEURONS ; MUSCLE ; 5-HT
英文摘要:

Background 5-hydroxytryptamine (5-HT) is a common neurotransmitter in the brain which plays an important role in the pathogenesis of sleep apnea. Dysfunction of 5-HT and 5-HT(2) receptors may lead to the collapse of the upper airway and the instability of respiratory control, which in turn produce apnea. Genioglossus (GG) is one of the most important oropharyngeal muscles maintaining the upper airway open. The present study aimed to investigate the effects of 5-HT and 5-HT(2) receptor on GG activity and the sleep apnea in Sprague-Dawley (SD) rats.

Methods Microinjection probes were placed within the fourth ventricle of sixteen SD rats. After recovery for a week, the electromyogram (EMG) of GG was recorded in the anesthetized and vagotomized rats. The changes of GG activity before and after the microinjection of 5-HT or 5-HT(2A/2C) agonist -2,5-dimethoxy-4-iodoamphetamine hydrochloride (DOI) were observed. Probes were also laid in another eight SD rats. Electroencephalogram (EEG), EMG of neck muscle and respiration were recorded at the same time a week later. The effects of DOI on the occurrence of sleep apnea were explored.

Results Both 5-HT and DOI significantly enhanced the activity of GG just 3 minutes after the completion of injection. The effect of 5-HT disappeared quickly and the effect of DOI lasted for more than 27 minutes. DOI also significantly decreased the post-sigh apnea index in non-rapid-eye-movement (NREM) and rapid-eye-movement (REM) sleep and decreased the spontaneous apnea index only in NREM sleep (P<0.05, respectively).

Conclusion 5-HT and 5-HT(2A/2C) system correlated closely with the pathogenesis of the sleep apnea syndrome and 5-HT receptors may become the target of the drug treatment. Chin Med J 2010;123(15):2094-2098

语种: 英语
所属项目编号: 30670920 ; 7072079
项目资助者: National Natural Science Foundation of China ; Beijing Municipal Natural Science Foundation of China
WOS记录号: WOS:000281025400026
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/67190
Appears in Collections:北京大学第一临床医学院_呼吸和危重症医学科_期刊论文

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作者单位: Peking Univ, Hosp 1, Dept Pulm Med, Beijing 100034, Peoples R China

Recommended Citation:
Zhong Yi-jue,Zhang Cheng,Wang Guang-fa. Effects of 5-hydroxytryptamine and 5-hydroxytryptamine 2A/2C agonist on the genioglossus activity and sleep apnea in rats[J]. CHINESE MEDICAL JOURNAL,2010,123(15):2094-2098.
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