|Effects of 5-hydroxytryptamine and 5-hydroxytryptamine 2A/2C agonist on the genioglossus activity and sleep apnea in rats|
|Zhong Yi-jue; Zhang Cheng; Wang Guang-fa|
|关键词||serotonin 5-hydroxytryptamine(2A/2C) rat sleep apnea genioglossus|
|刊名||CHINESE MEDICAL JOURNAL|
|WOS标题词||Science & Technology|
|类目[WOS]||Medicine, General & Internal|
|研究领域[WOS]||General & Internal Medicine|
|关键词[WOS]||HYPOGLOSSAL MOTOR NUCLEUS ; SEROTONIN ; MOTONEURONS ; MUSCLE ; 5-HT|
Background 5-hydroxytryptamine (5-HT) is a common neurotransmitter in the brain which plays an important role in the pathogenesis of sleep apnea. Dysfunction of 5-HT and 5-HT(2) receptors may lead to the collapse of the upper airway and the instability of respiratory control, which in turn produce apnea. Genioglossus (GG) is one of the most important oropharyngeal muscles maintaining the upper airway open. The present study aimed to investigate the effects of 5-HT and 5-HT(2) receptor on GG activity and the sleep apnea in Sprague-Dawley (SD) rats.
Methods Microinjection probes were placed within the fourth ventricle of sixteen SD rats. After recovery for a week, the electromyogram (EMG) of GG was recorded in the anesthetized and vagotomized rats. The changes of GG activity before and after the microinjection of 5-HT or 5-HT(2A/2C) agonist -2,5-dimethoxy-4-iodoamphetamine hydrochloride (DOI) were observed. Probes were also laid in another eight SD rats. Electroencephalogram (EEG), EMG of neck muscle and respiration were recorded at the same time a week later. The effects of DOI on the occurrence of sleep apnea were explored.
Results Both 5-HT and DOI significantly enhanced the activity of GG just 3 minutes after the completion of injection. The effect of 5-HT disappeared quickly and the effect of DOI lasted for more than 27 minutes. DOI also significantly decreased the post-sigh apnea index in non-rapid-eye-movement (NREM) and rapid-eye-movement (REM) sleep and decreased the spontaneous apnea index only in NREM sleep (P<0.05, respectively).
Conclusion 5-HT and 5-HT(2A/2C) system correlated closely with the pathogenesis of the sleep apnea syndrome and 5-HT receptors may become the target of the drug treatment. Chin Med J 2010;123(15):2094-2098
|项目编号||30670920 ; 7072079|
|资助机构||National Natural Science Foundation of China ; Beijing Municipal Natural Science Foundation of China|
|作者单位||Peking Univ, Hosp 1, Dept Pulm Med, Beijing 100034, Peoples R China|
|Zhong Yi-jue,Zhang Cheng,Wang Guang-fa. Effects of 5-hydroxytryptamine and 5-hydroxytryptamine 2A/2C agonist on the genioglossus activity and sleep apnea in rats[J]. CHINESE MEDICAL JOURNAL,2010,123(15):2094-2098.|
|APA||Zhong Yi-jue,Zhang Cheng,&Wang Guang-fa.(2010).Effects of 5-hydroxytryptamine and 5-hydroxytryptamine 2A/2C agonist on the genioglossus activity and sleep apnea in rats.CHINESE MEDICAL JOURNAL,123(15),2094-2098.|
|MLA||Zhong Yi-jue,et al."Effects of 5-hydroxytryptamine and 5-hydroxytryptamine 2A/2C agonist on the genioglossus activity and sleep apnea in rats".CHINESE MEDICAL JOURNAL 123.15(2010):2094-2098.|