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学科主题: 药学
题名:
All-trans retinoic acid stealth liposomes prevent the relapse of breast cancer arising from the cancer stem cells
作者: Li, Ruo-Jing; Ying, Xue; Zhang, Yan; Ju, Rui-Jun; Wang, Xiao-Xing; Yao, Hong-Juan; Men, Ying; Tian, Wei; Yu, Yang; Zhang, Liang; Huang, Ren-Jie; Lu, Wan-Liang1
关键词: All-trans retinoic acid stealth liposomes ; Cancer relapse model ; Breast cancer stem cells ; Differentiation ; Cell-cycle arrest
刊名: JOURNAL OF CONTROLLED RELEASE
发表日期: 2011-02-10
DOI: 10.1016/j.jconrel.2010.10.019
卷: 149, 期:3, 页:281-291
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Chemistry, Multidisciplinary ; Pharmacology & Pharmacy
研究领域[WOS]: Chemistry ; Pharmacology & Pharmacy
关键词[WOS]: ACUTE PROMYELOCYTIC LEUKEMIA ; PEGYLATED LIPOSOMES ; IN-VITRO ; BLOOD CLEARANCE ; CARCINOMA-CELLS ; SIDE POPULATION ; GROWTH ; MICE ; CHEMOTHERAPY ; INJECTION
英文摘要:

The relapse of cancer is mostly due to the proliferation of cancer stem cells which could not be eliminated by a standard chemotherapy. A new kind of all-trans retinoic acid stealth liposomes was developed for preventing the relapse of breast cancer and for treating the cancer in combination with a cytotoxic agent, vinorelbine stealth liposomes. In vitro studies were performed on the human breast cancer MCF-7 and MDA-MB-231 cells. In vivo evaluations were performed on the newly established relapse model with breast cancer stem cells. Results showed that the particle size of all-trans retinoic acid stealth liposomes was approximately 80 nm, and the encapsulation efficiency was > 90%. Breast cancer stem cells were identified with the CD44(+)/CD24(-) phenotype and characterized with properties: resistant to cytotoxic agent, stronger capability of proliferation, and stronger capability of differentiation. Inhibitory effect of all-trans retinoic acid stealth liposomes was more potent in cancer stem cells than in cancer cells. The mechanisms were defined to be two aspects: arresting breast cancer stem cells at the G(0)/G(1) phase in mitosis, and inducing the differentiation of breast cancer stem cells. The cancer relapse model was successfully established by xenografting breast cancer stem cells into NOD/SCID mice, and the formation and growth of the xenografted tumors were significantly inhibited by all-trans retinoic acid stealth liposomes. The combination therapy of all-trans retinoic acid stealth liposomes with vinorelbine stealth liposomes produced the strongest inhibitory effect to the relapse tumor model. It could be concluded that all-trans retinoic acid stealth liposomes could be used for preventing the relapse of breast cancer by differentiating cancer stem cells and arresting the cell-cycle, and for treating breast cancer as a co-therapy, thus providing a novel strategy for treating breast cancer and preventing relapse derived from breast cancer stem cells. (C) 2010 Elsevier B.V. All rights reserved.

语种: 英语
所属项目编号: 20070001741 ; 30772664 ; 7091005 ; 2009CB930300
项目资助者: Education Ministry of China ; National Natural Science Foundation of China ; Beijing Natural Science Foundation ; National Key Science Research Program of China (973 program)
WOS记录号: WOS:000288722800010
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/67197
Appears in Collections:北京大学药学院_药剂学系_期刊论文

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作者单位: 1.Peking Univ, Dept Pharmaceut, Sch Pharmaceut Sci, Beijing 100191, Peoples R China
2.Peking Univ, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China

Recommended Citation:
Li, Ruo-Jing,Ying, Xue,Zhang, Yan,et al. All-trans retinoic acid stealth liposomes prevent the relapse of breast cancer arising from the cancer stem cells[J]. JOURNAL OF CONTROLLED RELEASE,2011,149(3):281-291.
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