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学科主题: 基础医学
题名:
Mice Lacking Urea Transporter UT-B Display Depression-Like Behavior
作者: Li, Xin1,2; Ran, Jianhua3; Zhou, Hong1,2; Lei, Tianluo1,2; Zhou, Li1,2; Han, Jingyan4; Yang, Baoxue1,2
关键词: Urea ; Urea transporter ; Depression ; Hippocampus ; Nitric oxide
刊名: JOURNAL OF MOLECULAR NEUROSCIENCE
发表日期: 2012-02-01
DOI: 10.1007/s12031-011-9594-3
卷: 46, 期:2, 页:362-372
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Biochemistry & Molecular Biology ; Neurosciences
研究领域[WOS]: Biochemistry & Molecular Biology ; Neurosciences & Neurology
关键词[WOS]: NITRIC-OXIDE SYNTHASE ; URINE CONCENTRATING ABILITY ; L-ARGININE TRANSPORT ; LIVING RAT BRAIN ; NERVOUS-SYSTEM ; SEROTONIN TRANSPORTER ; ENDOTHELIAL-CELLS ; DIALYSIS PATIENTS ; MESSENGER-RNA ; WHITE-MATTER
英文摘要:

Urea transporter B is one of urea transporters that selectively transport urea driven by urea gradient across membrane and expressed abundantly in brain. To determine the physiological role of UT-B in brain, UT-B localization, urea concentration, tissue morphology of brain, and behavioral phenotypes were studied in UT-B heterozygous mice via UT-B null mice. UT-B mRNA was expressed in olfactory bulb, cortex, caudate nucleus, hippocampus and hypothalamus of UT-B heterozygous mice. UT-B null mice exhibited depression-like behavior, with urea accumulation, nitric oxide reduction, and selective neuronal nitric oxide synthase level increase in hippocampus. After acute urea loading, the urea level increased, NO production decreased in hippocampus from both types of mice. Moreover, urea level was higher, and NO concentration was lower consistently in UT-B null hippocampus than that in heterozygous hippocampus. In vitro, 25 mM urea inhibited NO production too. Furthermore, UT-B knockout induced a long-lasting notable decrease in regional cerebral blood flow and altered morphology, such as loss of neurons in CA3 region, swelling, and membranous myelin-like structure formation within myelinated and unmyelinated fibers in hippocampus. These results suggest that urea accumulation in the hippocampus induced by UT-B deletion can cause depression-like behavior, which possibly attribute to disturbance in NOS/NO system.

语种: 英语
所属项目编号: 30870921 ; 30500171 ; 985-2-094-121 ; 2009ZX09301-010-30 ; 20100001110047 ; 7102105
项目资助者: National Natural Science Foundation of China ; Ministry of Education of China ; Drug Discovery Program ; Doctoral Training Fund ; Beijing Natural Science Foundation
WOS记录号: WOS:000300345100014
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/67198
Appears in Collections:基础医学院_药理学系_期刊论文

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作者单位: 1.Minist Educ, Key Lab Mol Cardiovasc Sci, Beijing, Peoples R China
2.Peking Univ, Dept Pharmacol, Sch Basic Med Sci, Beijing 100191, Peoples R China
3.Chongqing Med Univ, Basic Med Coll, Neurosci Res Ctr, Dept Anat, Chongqing, Peoples R China
4.Peking Univ, Sch Basic Med Sci, Tasly Microcirculat Res Ctr, Beijing 100191, Peoples R China

Recommended Citation:
Li, Xin,Ran, Jianhua,Zhou, Hong,et al. Mice Lacking Urea Transporter UT-B Display Depression-Like Behavior[J]. JOURNAL OF MOLECULAR NEUROSCIENCE,2012,46(2):362-372.
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