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学科主题基础医学
Mice Lacking Urea Transporter UT-B Display Depression-Like Behavior
Li, Xin1,2; Ran, Jianhua3; Zhou, Hong1,2; Lei, Tianluo1,2; Zhou, Li1,2; Han, Jingyan4; Yang, Baoxue1,2
关键词Urea Urea transporter Depression Hippocampus Nitric oxide
刊名JOURNAL OF MOLECULAR NEUROSCIENCE
2012-02-01
DOI10.1007/s12031-011-9594-3
46期:2页:362-372
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biochemistry & Molecular Biology ; Neurosciences
研究领域[WOS]Biochemistry & Molecular Biology ; Neurosciences & Neurology
关键词[WOS]NITRIC-OXIDE SYNTHASE ; URINE CONCENTRATING ABILITY ; L-ARGININE TRANSPORT ; LIVING RAT BRAIN ; NERVOUS-SYSTEM ; SEROTONIN TRANSPORTER ; ENDOTHELIAL-CELLS ; DIALYSIS PATIENTS ; MESSENGER-RNA ; WHITE-MATTER
英文摘要

Urea transporter B is one of urea transporters that selectively transport urea driven by urea gradient across membrane and expressed abundantly in brain. To determine the physiological role of UT-B in brain, UT-B localization, urea concentration, tissue morphology of brain, and behavioral phenotypes were studied in UT-B heterozygous mice via UT-B null mice. UT-B mRNA was expressed in olfactory bulb, cortex, caudate nucleus, hippocampus and hypothalamus of UT-B heterozygous mice. UT-B null mice exhibited depression-like behavior, with urea accumulation, nitric oxide reduction, and selective neuronal nitric oxide synthase level increase in hippocampus. After acute urea loading, the urea level increased, NO production decreased in hippocampus from both types of mice. Moreover, urea level was higher, and NO concentration was lower consistently in UT-B null hippocampus than that in heterozygous hippocampus. In vitro, 25 mM urea inhibited NO production too. Furthermore, UT-B knockout induced a long-lasting notable decrease in regional cerebral blood flow and altered morphology, such as loss of neurons in CA3 region, swelling, and membranous myelin-like structure formation within myelinated and unmyelinated fibers in hippocampus. These results suggest that urea accumulation in the hippocampus induced by UT-B deletion can cause depression-like behavior, which possibly attribute to disturbance in NOS/NO system.

语种英语
WOS记录号WOS:000300345100014
项目编号30870921 ; 30500171 ; 985-2-094-121 ; 2009ZX09301-010-30 ; 20100001110047 ; 7102105
资助机构National Natural Science Foundation of China ; Ministry of Education of China ; Drug Discovery Program ; Doctoral Training Fund ; Beijing Natural Science Foundation
引用统计
被引频次:12[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/67198
专题北京大学基础医学院_药理学系
北京大学基础医学院
北京大学口腔医学院_消毒供应中心
作者单位1.Minist Educ, Key Lab Mol Cardiovasc Sci, Beijing, Peoples R China
2.Peking Univ, Dept Pharmacol, Sch Basic Med Sci, Beijing 100191, Peoples R China
3.Chongqing Med Univ, Basic Med Coll, Neurosci Res Ctr, Dept Anat, Chongqing, Peoples R China
4.Peking Univ, Sch Basic Med Sci, Tasly Microcirculat Res Ctr, Beijing 100191, Peoples R China
推荐引用方式
GB/T 7714
Li, Xin,Ran, Jianhua,Zhou, Hong,et al. Mice Lacking Urea Transporter UT-B Display Depression-Like Behavior[J]. JOURNAL OF MOLECULAR NEUROSCIENCE,2012,46(2):362-372.
APA Li, Xin.,Ran, Jianhua.,Zhou, Hong.,Lei, Tianluo.,Zhou, Li.,...&Yang, Baoxue.(2012).Mice Lacking Urea Transporter UT-B Display Depression-Like Behavior.JOURNAL OF MOLECULAR NEUROSCIENCE,46(2),362-372.
MLA Li, Xin,et al."Mice Lacking Urea Transporter UT-B Display Depression-Like Behavior".JOURNAL OF MOLECULAR NEUROSCIENCE 46.2(2012):362-372.
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