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Effects of nitric oxide and hydrogen sulfide on the relaxation of pulmonary arteries in rats
Wang Yan-Fei1; Mainali, Prabha1; Tang Chao-Shu2,3; Shi Lin1; Zhang Chun-Yu1; Yan Hui1; Liu Xue-Qin1; Du Jun-Bao1
关键词pulmonary artery nitric oxide hydrogen sulfide relaxation
刊名CHINESE MEDICAL JOURNAL
2008-03-05
121期:5页:420-423
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Medicine, General & Internal
研究领域[WOS]General & Internal Medicine
关键词[WOS]VASCULAR SMOOTH-MUSCLE ; RELAXING FACTOR ; L-ARGININE ; HYPERTENSION ; PATHOGENESIS ; PATHWAY ; CELLS ; VEIN ; H2S
英文摘要

Background The balance between vasodilation and vasoconstriction plays a major role in maintaining vascular homeostasis. However, the underlying mechanisms are unclear. More and more evidence suggested that there was an interaction in the regulation of vasorelaxation between nitric oxide (NO) and hydrogen sulfide (H(2)S). We explored the interaction between and effects of NO and H(2)S on the relaxation of pulmonary arteries in rats.

Methods Seven male Sprague-Dawley rats were anaesthetized with chloral hydrate and the pulmonary arteries of each rat separated for the study of vascular activities. The vasorelaxing activities of pulmonary artery rings in response to different doses of a NO donor, sodium nitroprusside (SNP), or a H(2)S donor, sodium hydrogensulfide (NaHS), were measured in vitro. When pulmonary artery rings were treated with a cystathionine-gamma-lyase inhibitor, DL-propargylglycine, in the presence of SNP or a nitric oxide synthase inhibitor, N(omega)-nitro-L-arginine methyl ester, in the presence of NaHS, the changes in relaxing activities were analyzed.

Results The relaxation of pulmonary artery rings was in a dose dependent manner in response to either SNP or NaHS. The relaxation rates of pulmonary artery rings increased from (30.90 +/- 4.62) % to (60.50 +/- 8.08) % when the concentration of SNP increased from 1 mu mol/L to 3 mu mol/L and from (26.13 +/- 4.12) % to (53.09 +/- 14.01) % when the concentration of NaHS increased from 25 mu mol/L to 100 mu mol/L. However, when appropriate inhibitor was added, the relaxation responses to SNP and NaHS decreased.

Conclusions The results suggested that similarly to NO, H(2)S acted as a vasorelaxant either independently of, or synergistically with NO in the regulation of vasorelaxation. The interaction between NO and H(2)S played an important role in regulating relaxing activities of pulmonary arteries.

语种英语
WOS记录号WOS:000254358500007
引用统计
被引频次:33[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/67202
专题北京大学第一临床医学院_儿科
北京大学第三临床医学院_血液内科
作者单位1.Peking Univ, Hosp 1, Dept Pediat, Beijing 100034, Peoples R China
2.Peking Univ, Hosp 1, Inst Cardiovasc Res, Beijing 100034, Peoples R China
3.Minist Educ, Key Lab Mol Cardiovasc Res, Beijing 100034, Peoples R China
推荐引用方式
GB/T 7714
Wang Yan-Fei,Mainali, Prabha,Tang Chao-Shu,et al. Effects of nitric oxide and hydrogen sulfide on the relaxation of pulmonary arteries in rats[J]. CHINESE MEDICAL JOURNAL,2008,121(5):420-423.
APA Wang Yan-Fei.,Mainali, Prabha.,Tang Chao-Shu.,Shi Lin.,Zhang Chun-Yu.,...&Du Jun-Bao.(2008).Effects of nitric oxide and hydrogen sulfide on the relaxation of pulmonary arteries in rats.CHINESE MEDICAL JOURNAL,121(5),420-423.
MLA Wang Yan-Fei,et al."Effects of nitric oxide and hydrogen sulfide on the relaxation of pulmonary arteries in rats".CHINESE MEDICAL JOURNAL 121.5(2008):420-423.
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