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学科主题: 临床医学
题名:
Association of the genetic variants of luteinizing hormone, luteinizing hormone receptor and polycystic ovary syndrome
作者: Liu, Nana1,2,3; Ma, Yanmin1,4; Wang, Shuyu4; Zhang, Xiaowei1,2,3; Zhang, Qiufang1,2,3; Zhang, Xue1,2,3; Fu, Li1,2,3; Qiao, Jie1,2,3
关键词: Luteinizing hormone ; Luteinizing hormone receptor ; Polycystic ovary syndrome ; Gene polymorphism
刊名: REPRODUCTIVE BIOLOGY AND ENDOCRINOLOGY
发表日期: 2012-04-30
DOI: 10.1186/1477-7827-10-36
卷: 10
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Endocrinology & Metabolism ; Reproductive Biology
研究领域[WOS]: Endocrinology & Metabolism ; Reproductive Biology
关键词[WOS]: BETA-SUBUNIT VARIANT ; GRANULOSA-CELLS ; GONADOTROPIN RECEPTORS ; MOLECULAR VARIANTS ; MUTATIONS ; PROTEIN ; WOMEN ; LH ; PATHOPHYSIOLOGY ; POLYMORPHISMS
英文摘要:

Background: High circulating luteinizing hormone (LH) level is a typical biochemical feature of polycystic ovary syndrome (PCOS) whose pathophysiology is still unclear. Certain mutations of LH and LH receptor (LHR) may lead to changes in bioactivity of these hormones. The aim of this study was determine the role of the LH and LHR polymorphisms in the pathogenesis of PCOS using a genetic approach.

Methods: 315 PCOS women and 212 controls were screened for the gene variants of LH G1052A and LHR rs61996318 polymorphisms by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP).

Results: PCOS patients had significantly more A allele frequency of LH G1052A mutations than controls (p = 0.001). Within PCOS group, carriers of LH 1052A allele had lower LH (p = 0.05) and higher fasting glucose levels (p = 0.04). No subjects were identified with LHR rs61996318 polymorphisms. A new LHR single nucleotide polymorphism (SNP) was found without clear association with PCOS.

Conclusions: Results suggested LH G1052A mutation might influence PCOS susceptibility and phenotypes.

语种: 英语
所属项目编号: 20090001110090 ; 30825038 ; 81170538
项目资助者: Doctoral Foundation of Education Ministry of China ; National Natural Science Foundation ; National Natural Science Foundation of China
WOS记录号: WOS:000306611700001
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/67203
Appears in Collections:北京大学第三临床医学院_生殖医学中心_期刊论文

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作者单位: 1.Peking Univ, Hosp 3, Dept Obstet & Gynecol, Ctr Reprod Med, Beijing 100191, Peoples R China
2.Minist Educ, Key Lab Assisted Reprod, Beijing 100191, Peoples R China
3.Beijing Key Lab Reprod Endocrinol & Assisted Repr, Beijing 100191, Peoples R China
4.Capital Med Univ, Beijing Obstet & Gynecol Hosp, Reprod Med Ctr, Beijing 100026, Peoples R China

Recommended Citation:
Liu, Nana,Ma, Yanmin,Wang, Shuyu,et al. Association of the genetic variants of luteinizing hormone, luteinizing hormone receptor and polycystic ovary syndrome[J]. REPRODUCTIVE BIOLOGY AND ENDOCRINOLOGY,2012,10.
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