IR@PKUHSC  > 北京大学第三临床医学院  > 妇产科
学科主题临床医学
Association of the genetic variants of luteinizing hormone, luteinizing hormone receptor and polycystic ovary syndrome
Liu, Nana1,2,3; Ma, Yanmin1,4; Wang, Shuyu4; Zhang, Xiaowei1,2,3; Zhang, Qiufang1,2,3; Zhang, Xue1,2,3; Fu, Li1,2,3; Qiao, Jie1,2,3
关键词Luteinizing hormone Luteinizing hormone receptor Polycystic ovary syndrome Gene polymorphism
刊名REPRODUCTIVE BIOLOGY AND ENDOCRINOLOGY
2012-04-30
DOI10.1186/1477-7827-10-36
10
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Endocrinology & Metabolism ; Reproductive Biology
研究领域[WOS]Endocrinology & Metabolism ; Reproductive Biology
关键词[WOS]BETA-SUBUNIT VARIANT ; GRANULOSA-CELLS ; GONADOTROPIN RECEPTORS ; MOLECULAR VARIANTS ; MUTATIONS ; PROTEIN ; WOMEN ; LH ; PATHOPHYSIOLOGY ; POLYMORPHISMS
英文摘要

Background: High circulating luteinizing hormone (LH) level is a typical biochemical feature of polycystic ovary syndrome (PCOS) whose pathophysiology is still unclear. Certain mutations of LH and LH receptor (LHR) may lead to changes in bioactivity of these hormones. The aim of this study was determine the role of the LH and LHR polymorphisms in the pathogenesis of PCOS using a genetic approach.

Methods: 315 PCOS women and 212 controls were screened for the gene variants of LH G1052A and LHR rs61996318 polymorphisms by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP).

Results: PCOS patients had significantly more A allele frequency of LH G1052A mutations than controls (p = 0.001). Within PCOS group, carriers of LH 1052A allele had lower LH (p = 0.05) and higher fasting glucose levels (p = 0.04). No subjects were identified with LHR rs61996318 polymorphisms. A new LHR single nucleotide polymorphism (SNP) was found without clear association with PCOS.

Conclusions: Results suggested LH G1052A mutation might influence PCOS susceptibility and phenotypes.

语种英语
WOS记录号WOS:000306611700001
项目编号20090001110090 ; 30825038 ; 81170538
资助机构Doctoral Foundation of Education Ministry of China ; National Natural Science Foundation ; National Natural Science Foundation of China
引用统计
被引频次:14[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/67203
专题北京大学第三临床医学院_妇产科
北京大学第三临床医学院_生殖医学中心
作者单位1.Peking Univ, Hosp 3, Dept Obstet & Gynecol, Ctr Reprod Med, Beijing 100191, Peoples R China
2.Minist Educ, Key Lab Assisted Reprod, Beijing 100191, Peoples R China
3.Beijing Key Lab Reprod Endocrinol & Assisted Repr, Beijing 100191, Peoples R China
4.Capital Med Univ, Beijing Obstet & Gynecol Hosp, Reprod Med Ctr, Beijing 100026, Peoples R China
推荐引用方式
GB/T 7714
Liu, Nana,Ma, Yanmin,Wang, Shuyu,et al. Association of the genetic variants of luteinizing hormone, luteinizing hormone receptor and polycystic ovary syndrome[J]. REPRODUCTIVE BIOLOGY AND ENDOCRINOLOGY,2012,10.
APA Liu, Nana.,Ma, Yanmin.,Wang, Shuyu.,Zhang, Xiaowei.,Zhang, Qiufang.,...&Qiao, Jie.(2012).Association of the genetic variants of luteinizing hormone, luteinizing hormone receptor and polycystic ovary syndrome.REPRODUCTIVE BIOLOGY AND ENDOCRINOLOGY,10.
MLA Liu, Nana,et al."Association of the genetic variants of luteinizing hormone, luteinizing hormone receptor and polycystic ovary syndrome".REPRODUCTIVE BIOLOGY AND ENDOCRINOLOGY 10(2012).
条目包含的文件
条目无相关文件。
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Liu, Nana]的文章
[Ma, Yanmin]的文章
[Wang, Shuyu]的文章
百度学术
百度学术中相似的文章
[Liu, Nana]的文章
[Ma, Yanmin]的文章
[Wang, Shuyu]的文章
必应学术
必应学术中相似的文章
[Liu, Nana]的文章
[Ma, Yanmin]的文章
[Wang, Shuyu]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。