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Parenteral nanosuspension of a novel synthesized antitumor candidate: Investigation of tissue biodistributions and plasma pharmacokinetics
Tian, Xiaona1; Li, Han2; Zhang, Dianrui1; Shen, Jingyi1; Jia, Lejiao1; Zheng, Dandan1; Liu, Guangpu1; Hao, Leilei1; Shen, Yuemao3; Zhang, Qiang4
关键词A novel synthesized p-terphenyl derivative Nanosuspension Biodistribution Pharmacokinetics Chemical stability
刊名COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
2013-09-05
DOI10.1016/j.colsurfa.2013.08.029
436页:868-872
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Chemistry, Physical
研究领域[WOS]Chemistry
关键词[WOS]POORLY SOLUBLE DRUGS ; IN-VIVO EVALUATION ; PARTICLE-SIZE ; DELIVERY ; NANOCRYSTALS ; VITRO
英文摘要

Previously, nanosuspension of a novel synthesized p-terphenyl derivative (H2,) with a mean particle size of 201.7 +/- 5.87 nm was prepared using precipitation-microfluidization method. Enhanced saturation solubility and accelerated dissolution velocity were achieved. The objectives of this current study were to investigate the tissue biodistribution and plasma pharmacokinetic properties of H2 nanosuspension comparing with that of H2 solution after intravenously administration to mice. In an attempt to ensure the drug content accuracy during the animal tests, chemical stability of H2 nanosuspension was also monitored over a 1 month period. As shown in the plasma concentration time profiles, drug nanosuspensions were effective in increasing the plasma level of H2 compared to drug solution. In particular, the initial concentration of H2 administered as nanosuspension and solution were 13.05 mu g/mL and 5.54 mu g/mL, respectively. What′s more, compared with H2 solution, nanosuspension significantly changed drug biodistribution features in tissues, relatively increased drug concentration in liver and lung, and decreased that in other tissues. (C) 2013 Elsevier B.V. All rights reserved.

语种英语
WOS记录号WOS:000326416900107
项目编号2009CB930300
资助机构National Basic Research Program of China (973 Program)
引用统计
被引频次:7[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/67210
专题北京大学药学院
北京大学药学院_药剂学系
作者单位1.Shandong Univ, Dept Pharmaceut, Coll Pharm, Jinan 250012, Peoples R China
2.Shandong Univ, Dept Microbial & Biochem Pharm, Coll Pharm, Jinan 250012, Peoples R China
3.Shandong Univ, Dept Nat Med Chem, Coll Pharm, Jinan 250012, Peoples R China
4.Peking Univ, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing 100083, Peoples R China
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GB/T 7714
Tian, Xiaona,Li, Han,Zhang, Dianrui,et al. Parenteral nanosuspension of a novel synthesized antitumor candidate: Investigation of tissue biodistributions and plasma pharmacokinetics[J]. COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS,2013,436:868-872.
APA Tian, Xiaona.,Li, Han.,Zhang, Dianrui.,Shen, Jingyi.,Jia, Lejiao.,...&Zhang, Qiang.(2013).Parenteral nanosuspension of a novel synthesized antitumor candidate: Investigation of tissue biodistributions and plasma pharmacokinetics.COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS,436,868-872.
MLA Tian, Xiaona,et al."Parenteral nanosuspension of a novel synthesized antitumor candidate: Investigation of tissue biodistributions and plasma pharmacokinetics".COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS 436(2013):868-872.
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