IR@PKUHSC  > 北京大学基础医学院  > 免疫学系
学科主题基础医学
Differential chemotactic potential of mouse platelet basic protein for thymocyte subsets
Fu, WX; Gong, SY; Qian, XP; Li, Y; Zhu, ML; Dong, XY; Li, Y; Chen, WF
关键词chemokine chemotaxis monocyte/macrophage stromal cell thymus
刊名CELLULAR AND MOLECULAR LIFE SCIENCES
2004-07-01
DOI10.1007/s00018-004-4137-5
61期:15页:1935-1945
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biochemistry & Molecular Biology ; Cell Biology
研究领域[WOS]Biochemistry & Molecular Biology ; Cell Biology
关键词[WOS]MACROPHAGE-DERIVED CHEMOKINE ; MEDULLARY EPITHELIAL-CELLS ; IL-8 RECEPTOR HOMOLOG ; BONE-MARROW ; T-CELLS ; PROGENITOR CELLS ; LINE MTEC1 ; MURINE ; NEUTROPHIL ; EXPRESSION
英文摘要

Mouse platelet basic protein (CXCL7/mPBP) was cloned from thymic stromal cells and further identification indicated that it was expressed in thymic monocytes/macrophages (Mo/Mphis). Recombinant mPBP was chemoattractive for target cells of polymorphonuclear leucocytes, peritoneal Mo/Mphis and splenic lymphocytes with distinct potencies. CXCR2 was identified to be a cognate receptor for mPBP. Mouse thymocyte subsets of CD4(-)CD8(-) double-negative (DN), CD4(+)CD8(+) double-positive (DP), CD4(+)CD8(-) single-positive (CD4SP) and CD4(-)CD8(+) single-positive (CD8SP) expressed cell surface CXCR2 with different positive percentages and expression levels. mPBP was chemoattractive for thymocyte subsets with the potency order DN>DP> CD8SP>CD4SP, consistent with the levels of CXCR2 expressed on the respective cells. Thus, mPBP in thymus is functionally redundant with chemokine CXCL12/ SDF-1. Moreover, our finding that thymic Mo/Mphis can produce mPBP implies that they may have other functions apart from acting as scavengers in thymus.

语种英语
WOS记录号WOS:000223024200009
引用统计
被引频次:5[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
版本出版稿
条目标识符http://ir.bjmu.edu.cn/handle/400002259/67214
专题北京大学基础医学院_免疫学系
作者单位Peking Univ, Hlth Sci Ctr, Dept Immunol, Beijing 100083, Peoples R China
推荐引用方式
GB/T 7714
Fu, WX,Gong, SY,Qian, XP,et al. Differential chemotactic potential of mouse platelet basic protein for thymocyte subsets[J]. CELLULAR AND MOLECULAR LIFE SCIENCES,2004,61(15):1935-1945.
APA Fu, WX.,Gong, SY.,Qian, XP.,Li, Y.,Zhu, ML.,...&Chen, WF.(2004).Differential chemotactic potential of mouse platelet basic protein for thymocyte subsets.CELLULAR AND MOLECULAR LIFE SCIENCES,61(15),1935-1945.
MLA Fu, WX,et al."Differential chemotactic potential of mouse platelet basic protein for thymocyte subsets".CELLULAR AND MOLECULAR LIFE SCIENCES 61.15(2004):1935-1945.
条目包含的文件
文件名称/大小 文献类型 版本类型 开放类型 使用许可
art%3A10.1007%2Fs000(396KB)期刊论文出版稿开放获取CC BY-NC-SA浏览 请求全文
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Fu, WX]的文章
[Gong, SY]的文章
[Qian, XP]的文章
百度学术
百度学术中相似的文章
[Fu, WX]的文章
[Gong, SY]的文章
[Qian, XP]的文章
必应学术
必应学术中相似的文章
[Fu, WX]的文章
[Gong, SY]的文章
[Qian, XP]的文章
相关权益政策
暂无数据
收藏/分享
文件名: art%3A10.1007%2Fs00018-004-4137-5.pdf
格式: Adobe PDF
此文件暂不支持浏览
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。