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学科主题: 基础医学
题名:
Differential chemotactic potential of mouse platelet basic protein for thymocyte subsets
作者: Fu, WX; Gong, SY; Qian, XP; Li, Y; Zhu, ML; Dong, XY; Li, Y; Chen, WF
关键词: chemokine ; chemotaxis ; monocyte/macrophage ; stromal cell ; thymus
刊名: CELLULAR AND MOLECULAR LIFE SCIENCES
发表日期: 2004-07-01
DOI: 10.1007/s00018-004-4137-5
卷: 61, 期:15, 页:1935-1945
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Biochemistry & Molecular Biology ; Cell Biology
研究领域[WOS]: Biochemistry & Molecular Biology ; Cell Biology
关键词[WOS]: MACROPHAGE-DERIVED CHEMOKINE ; MEDULLARY EPITHELIAL-CELLS ; IL-8 RECEPTOR HOMOLOG ; BONE-MARROW ; T-CELLS ; PROGENITOR CELLS ; LINE MTEC1 ; MURINE ; NEUTROPHIL ; EXPRESSION
英文摘要:

Mouse platelet basic protein (CXCL7/mPBP) was cloned from thymic stromal cells and further identification indicated that it was expressed in thymic monocytes/macrophages (Mo/Mphis). Recombinant mPBP was chemoattractive for target cells of polymorphonuclear leucocytes, peritoneal Mo/Mphis and splenic lymphocytes with distinct potencies. CXCR2 was identified to be a cognate receptor for mPBP. Mouse thymocyte subsets of CD4(-)CD8(-) double-negative (DN), CD4(+)CD8(+) double-positive (DP), CD4(+)CD8(-) single-positive (CD4SP) and CD4(-)CD8(+) single-positive (CD8SP) expressed cell surface CXCR2 with different positive percentages and expression levels. mPBP was chemoattractive for thymocyte subsets with the potency order DN>DP> CD8SP>CD4SP, consistent with the levels of CXCR2 expressed on the respective cells. Thus, mPBP in thymus is functionally redundant with chemokine CXCL12/ SDF-1. Moreover, our finding that thymic Mo/Mphis can produce mPBP implies that they may have other functions apart from acting as scavengers in thymus.

语种: 英语
WOS记录号: WOS:000223024200009
Citation statistics:
内容类型: 期刊论文
版本: 出版稿
URI标识: http://ir.bjmu.edu.cn/handle/400002259/67214
Appears in Collections:基础医学院_免疫学系_期刊论文

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作者单位: Peking Univ, Hlth Sci Ctr, Dept Immunol, Beijing 100083, Peoples R China

Recommended Citation:
Fu, WX,Gong, SY,Qian, XP,et al. Differential chemotactic potential of mouse platelet basic protein for thymocyte subsets[J]. CELLULAR AND MOLECULAR LIFE SCIENCES,2004,61(15):1935-1945.
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