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学科主题: 药学
题名:
Antidepressant-like effect of liquiritin from Glycyrrhiza uralensis in chronic variable stress induced depression model rats
作者: Zhao, Zhiyu2; Wang, Weixing1; Guo, Hongzhu1; Zhou, Dongfeng2
关键词: liquiritin ; Glycyrrhiza uralensis ; antidepressant-like ; chronic variable stress ; forced swim test ; superoxide dismutase ; malondialdehyde
刊名: BEHAVIOURAL BRAIN RESEARCH
发表日期: 2008-12-01
DOI: 10.1016/j.bbr.2008.06.030
卷: 194, 期:1, 页:108-113
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Behavioral Sciences ; Neurosciences
研究领域[WOS]: Behavioral Sciences ; Neurosciences & Neurology
关键词[WOS]: FORCED SWIMMING TEST ; HYPERICUM-PERFORATUM ; LIPID-PEROXIDATION ; MAJOR DEPRESSION ; OXIDATIVE DAMAGE ; SUPEROXIDE-DISMUTASE ; ANTIOXIDANT ACTIVITY ; ENZYME-ACTIVITIES ; LICORICE ROOT ; EXTRACTS
英文摘要:

Many flavonoids extracted from nature plants have been reported to exert antidepressant-like effect in animal studies. The present Study was designed to observe the effects of liquiritin, a flavone compound derived from Glycyrrhiza uralensis, on the behaviors of chronic variable stress induced depression model rats and to explore the possible association between its antidepressant-like effect and antioxidative activity by measuring erythrocyte superoxide dismutase (SOD) activity and plasma malondialdehyde (MDA) level of the experimental animals. With the exposure to stressor once daily for consecutive 5 weeks, liquiritin and a positive control drug fluoxetine were administered via gastric intubation to rats once daily for consecutive 3 weeks from the 3rd week. The results showed that CVS reduced open-field activity and sucrose consumption significantly, but increased immobility time in forced swimming test. Treatment of liquiritin could effectively reverse alteration in immobility time and Sucrose consumption but did not show significant effect on open-field activity. Moreover, liquiritin could increase SOD activity, inhibit lipid peroxidation, and lessen production of MDA, while fluoxetine did not. In conclusion, the present study demonstrated a potential antidepressant-like effect of liquiritin treatment on chronic variable Stress induced depression model Fats, which might be related to defense of liquiritin against oxidative stress. (C) 2008 Elsevier B.V. All rights reserved.

语种: 英语
所属项目编号: 7062039 ; 404
项目资助者: Beijing Natural Science Foundation ; National "211 Project" Peking University EBM Group
WOS记录号: WOS:000259713000015
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/67224
Appears in Collections:北京大学药学院_期刊论文

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作者单位: 1.Peking Univ, Sch Pharmaceut Sci, Div Pharmacognost Biotechnol, Beijing 100083, Peoples R China
2.Peking Univ, Inst Mental Hlth, Minist Hlth, Key Lab Mental Hlth, Beijing 100083, Peoples R China

Recommended Citation:
Zhao, Zhiyu,Wang, Weixing,Guo, Hongzhu,et al. Antidepressant-like effect of liquiritin from Glycyrrhiza uralensis in chronic variable stress induced depression model rats[J]. BEHAVIOURAL BRAIN RESEARCH,2008,194(1):108-113.
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