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学科主题: 药学
题名:
Induction of Apoptosis by Chelerythrine Chloride through Mitochondrial Pathway and Bcl-2 Family Proteins in Human Hepatoma SMMC-7721 Cell
作者: Zhang, Zheng-fu1; Guo, Ying2; Zhang, Jian-bin3; Wei, Xiong-hui1
关键词: Chelerythrine chloride ; Proliferation ; Apoptosis ; Human hepatoma SMMC-7721 ; Mitochondrial pathway ; Bcl-2 family proteins
刊名: ARCHIVES OF PHARMACAL RESEARCH
发表日期: 2011-05-01
DOI: 10.1007/s12272-011-0513-5
卷: 34, 期:5, 页:791-800
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Chemistry, Medicinal ; Pharmacology & Pharmacy
研究领域[WOS]: Pharmacology & Pharmacy
关键词[WOS]: HEPATOCELLULAR-CARCINOMA ; CANCER-CELLS ; IN-VITRO ; KINASE-C ; CYTOCHROME-C ; SANGUINARINE ; CYCLE ; INHIBITOR ; LEUKEMIA ; THERAPY
英文摘要:

The objective of this study was to evaluate the antitumor activity of chelerythrine chloride (CHE) and investigate its potential apoptotic induction mechanism in SMMC-7721 cells. Our results suggested that the proliferation of SMMC-7721 cells was inhibited by CHE in a time and dose dependent manner, with a significant accumulation in S phase, and the cells exhibited typical apoptotic features. Moreover, CHE remarkably induced apoptosis by disruption of the mitochondrial membrane potential, release of Cyt-c, activation of caspase-3, and cleavage of poly-ADP-ribose polymerase in a dose dependent manner. Furthermore, the expression of Bcl-xl was downregulated while Bax and Bid expression was upregulated, and no variation was found for Bcl-2. These results indicated that CHE may play an important role in suppression of tumor growth by inducing apoptosis in human hepatoma cells via the activation of a mitochondrial pathway and regulating the expression of Bcl-2 family proteins.

语种: 英语
所属项目编号: 20080430283
项目资助者: China Postdoctoral Science Foundation ; Jiangxi Yongfeng Boyuan Industry Co., Ltd.
WOS记录号: WOS:000291365900015
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/67226
Appears in Collections:北京大学药学院_化学生物学系_期刊论文

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作者单位: 1.Peking Univ, Coll Chem & Mol Engn, Dept Appl Chem, Beijing 100871, Peoples R China
2.Peking Univ, Dept Biol Chem, Sch Pharmaceut Sci, Beijing 100083, Peoples R China
3.Inner Mongolia Univ Technol, Coll Chem Engn, Hohhot 010051, Peoples R China

Recommended Citation:
Zhang, Zheng-fu,Guo, Ying,Zhang, Jian-bin,et al. Induction of Apoptosis by Chelerythrine Chloride through Mitochondrial Pathway and Bcl-2 Family Proteins in Human Hepatoma SMMC-7721 Cell[J]. ARCHIVES OF PHARMACAL RESEARCH,2011,34(5):791-800.
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