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The promoting effect of eucommiol from eucommiae cortex on collagen synthesis
Li, YM; Kamo, S; Metori, K; Koike, K; Che, WM; Takahashi, S
关键词Eucommiae-Cortex eucommiol bark geniposide collagen-synthesis granuloma
刊名BIOLOGICAL & PHARMACEUTICAL BULLETIN
2000
23期:1页:54-59
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Pharmacology & Pharmacy
研究领域[WOS]Pharmacology & Pharmacy
关键词[WOS]ULMOIDES OLIV ; MUSCLE PROTEIN ; CONSTITUENTS ; GENIPOSIDE ; HEPATOTOXICITY ; GLYCOSIDE ; LEAF ; RATS
英文摘要

The effect of a methanol extract of Eucommiae Cortex on collagen synthesis was investigated in false aged model rats, Granuloma formation and collagen synthesis were significantly increased by the administration of the methanol extract of Eucommiae Cortex, The effective component of Eucommiae Cortex was then discussed by fractionating the methanol extract of Eucommiae Cortex, Eucommiol, a main component in the water fraction of the methanol extract, was found to be an effective compound, In our previous paper, we reported the promoting effect of Eucommia ulmoides OLIVER leaf on collagen synthesis, and found geniposidic acid and aucubin were the main effective compounds in the leaf. Based on our data in this paper, we clarified that the main effective components of the Eucommia ulmoides OLIVER leaf and Eucommiae Cortex were different. Geniposidic acid and aucubin were reported to be contained at a high concentration in the fresh cortex of Eucommia ulmoides OLIVER, but during the drying process and storage, most of them were destroyed by enzymes in the cortex and very little remained in the Eucommiae Col tex. Therefore,we investigated the effect of the methanol extract of fresh cortex of Eucommia ulmoides OLIVER, A stronger effect than Eucommiae cortex was shown, and geniposidic acid, aucubin and geniposide were concluded to be the main effective components, Although geniposide was found to be an effective compound, when the dose was higher than 50 mg/kg/d, toxicity was shown, The pharmaceutical effect of eucommiol was reported for the first time.

语种英语
WOS记录号WOS:000084907600011
引用统计
被引频次:29[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/67227
专题北京大学药学院
作者单位1.Nihon Univ, Coll Pharm, Biochem Lab, Chiba 2148555, Japan
2.Nihon Univ, Coll Pharm, Ctr Analyt Chem, Chiba 2748555, Japan
3.Beijing Med Univ, Sch Pharmaceut Sci, Dept Tradit Chinese Med, Beijing 100083, Peoples R China
4.Nihon Univ, Coll Ind Technol, Chiba 2758575, Japan
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GB/T 7714
Li, YM,Kamo, S,Metori, K,et al. The promoting effect of eucommiol from eucommiae cortex on collagen synthesis[J]. BIOLOGICAL & PHARMACEUTICAL BULLETIN,2000,23(1):54-59.
APA Li, YM,Kamo, S,Metori, K,Koike, K,Che, WM,&Takahashi, S.(2000).The promoting effect of eucommiol from eucommiae cortex on collagen synthesis.BIOLOGICAL & PHARMACEUTICAL BULLETIN,23(1),54-59.
MLA Li, YM,et al."The promoting effect of eucommiol from eucommiae cortex on collagen synthesis".BIOLOGICAL & PHARMACEUTICAL BULLETIN 23.1(2000):54-59.
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