IR@PKUHSC  > 北京大学第一临床医学院
学科主题临床医学
Vaginal allergic response in women with vulvovaginal candidiasis
Fan, S. R.1,2; Liao, Q. P.1; Liu, X. P.3; Liu, Z. H.1; Zhang, D.1
关键词allergic response chemokines cytokines immunoglobulin vulvovaginal candidiasis
刊名INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS
2008-04-01
DOI10.1016/j.ijgo.2007.08.024
101期:1页:27-30
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Obstetrics & Gynecology
研究领域[WOS]Obstetrics & Gynecology
关键词[WOS]MANNOSE-BINDING LECTIN ; INTRAVAGINAL CHALLENGE ; RECURRENT VAGINITIS ; GENE POLYMORPHISM ; IGE ANTIBODIES ; ALBICANS ; CELLS ; IL-4 ; ANTIGEN
英文摘要

Objective: To determine the concentration of certain cytokines and immunoglobulin (Ig) E in the vaginal Lavage fluid (VLF) of women with vulvovaginal candidiasis (VVC). Method: Cytokin and IgE concentrations were measured in the VLF of women with VVC; women free of any genital infections acted as controls. Result: The VLF concentrations of interleukin (IL)-2, IL-8, and interferon (INF)-gamma were higher among women with VVC than in the control group; women with severe VVC had a higher VLF concentration of IL-4 than those with mild to moderate VVC; women with cured VVC had a higher VLF concentration of IL-13 than did controls; and women with VVC or cured VVC had a higher VLF concentration of IgE than did controls (P<0.05 for all). Conclusion: Both helper T cells type 1 and innate response cytokines were shown to play a dominant role in the pathogenesis of VVC. This allergic vaginal response in women with VVC suggests that the form of treatment for VVC should be reconsidered. (C) 2008 International Federation of Gynecology and Obstetrics. Published by Elsevier Ireland Ltd. All rights reserved.

语种英语
WOS记录号WOS:000255150000006
引用统计
被引频次:12[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/67229
专题北京大学第一临床医学院
北京大学第一临床医学院_妇产科
作者单位1.Peking Univ, Hosp 1, Dept Obstet & Gynecol, Beijing 100871, Peoples R China
2.Peking Univ, Shenzhen Hosp, Dept Obstet & Gynecol, Shenzhen, Peoples R China
3.Peking Univ, Shenzhen Hosp, Dept Lab Sci, Shenzhen, Peoples R China
推荐引用方式
GB/T 7714
Fan, S. R.,Liao, Q. P.,Liu, X. P.,et al. Vaginal allergic response in women with vulvovaginal candidiasis[J]. INTERNATIONAL JOURNAL OF GYNECOLOGY &amp; OBSTETRICS,2008,101(1):27-30.
APA Fan, S. R.,Liao, Q. P.,Liu, X. P.,Liu, Z. H.,&Zhang, D..(2008).Vaginal allergic response in women with vulvovaginal candidiasis.INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS,101(1),27-30.
MLA Fan, S. R.,et al."Vaginal allergic response in women with vulvovaginal candidiasis".INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS 101.1(2008):27-30.
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