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学科主题: 临床医学
题名:
Vaginal allergic response in women with vulvovaginal candidiasis
作者: Fan, S. R.1,2; Liao, Q. P.1; Liu, X. P.3; Liu, Z. H.1; Zhang, D.1
关键词: allergic response ; chemokines ; cytokines ; immunoglobulin ; vulvovaginal candidiasis
刊名: INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS
发表日期: 2008-04-01
DOI: 10.1016/j.ijgo.2007.08.024
卷: 101, 期:1, 页:27-30
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Obstetrics & Gynecology
研究领域[WOS]: Obstetrics & Gynecology
关键词[WOS]: MANNOSE-BINDING LECTIN ; INTRAVAGINAL CHALLENGE ; RECURRENT VAGINITIS ; GENE POLYMORPHISM ; IGE ANTIBODIES ; ALBICANS ; CELLS ; IL-4 ; ANTIGEN
英文摘要:

Objective: To determine the concentration of certain cytokines and immunoglobulin (Ig) E in the vaginal Lavage fluid (VLF) of women with vulvovaginal candidiasis (VVC). Method: Cytokin and IgE concentrations were measured in the VLF of women with VVC; women free of any genital infections acted as controls. Result: The VLF concentrations of interleukin (IL)-2, IL-8, and interferon (INF)-gamma were higher among women with VVC than in the control group; women with severe VVC had a higher VLF concentration of IL-4 than those with mild to moderate VVC; women with cured VVC had a higher VLF concentration of IL-13 than did controls; and women with VVC or cured VVC had a higher VLF concentration of IgE than did controls (P<0.05 for all). Conclusion: Both helper T cells type 1 and innate response cytokines were shown to play a dominant role in the pathogenesis of VVC. This allergic vaginal response in women with VVC suggests that the form of treatment for VVC should be reconsidered. (C) 2008 International Federation of Gynecology and Obstetrics. Published by Elsevier Ireland Ltd. All rights reserved.

语种: 英语
WOS记录号: WOS:000255150000006
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/67229
Appears in Collections:北京大学第一临床医学院_期刊论文

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作者单位: 1.Peking Univ, Hosp 1, Dept Obstet & Gynecol, Beijing 100871, Peoples R China
2.Peking Univ, Shenzhen Hosp, Dept Obstet & Gynecol, Shenzhen, Peoples R China
3.Peking Univ, Shenzhen Hosp, Dept Lab Sci, Shenzhen, Peoples R China

Recommended Citation:
Fan, S. R.,Liao, Q. P.,Liu, X. P.,et al. Vaginal allergic response in women with vulvovaginal candidiasis[J]. INTERNATIONAL JOURNAL OF GYNECOLOGY &amp; OBSTETRICS,2008,101(1):27-30.
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