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Successfully tailoring the pore size of mesoporous silica nanoparticles: Exploitation of delivery systems for poorly water-soluble drugs
Jia, Lejiao1; Shen, Jingyi1; Li, Zhenyu2; Zhang, Dianrui1; Zhang, Qiang3; Duan, Cunxian1; Liu, Guangpu1; Zheng, Dandan1; Liu, Yue1; Tian, Xiaona1
关键词Mesoporous silica nanoparticles Pore sizes Paclitaxel Poor water solubility In vitro anti-tumor
刊名INTERNATIONAL JOURNAL OF PHARMACEUTICS
2012-12-15
DOI10.1016/j.ijpharm.2012.10.011
439期:1-2页:81-91
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Pharmacology & Pharmacy
研究领域[WOS]Pharmacology & Pharmacy
关键词[WOS]POLYMERIC MICELLES ; CONTROLLED-RELEASE ; ANTICANCER DRUGS ; NANOCRYSTALS ; NANOEMULSION ; FORMULATION ; ENDOCYTOSIS ; PACLITAXEL ; EFFICACY ; CARRIERS
英文摘要

A novel approach was applied to fabricate mesoporous silica nanoparticles (MSNs) with different pore size in this study. The pore size of MSNs can be modulated conveniently from 3 nm to 10 nm by controlling the etching time of MSNs with the NaBH4 solution. The as-synthesized MSNs were investigated as carriers for loading and delivery of the model drug paclitaxel (PTX). The characteristics, drug loading capacity, in vitro drug release behavior, anti-tumor activity and the mechanism of cell uptake were systematically studies. The resultant MSNs showed uniform and mono-dispersed sphere with high drug loading capacity (12-21%). The in vitro drug release exhibited that the released rate of PTX from MSNs could be controlled by the pore size and the larger the pore size, the faster the release rate of PTX. The in vitro anti-tumor studies demonstrated that PTX-loaded MSNs produced higher cytotoxicity than free PTX. Besides, the PTX-loaded MSNs with largest pore size showed the highest anti-tumor activity. These results indicated that these MSNs could provide a promising platform for delivering water-insoluble drugs, controlling the release rate of drugs and increasing the anti-tumor activity. (C) 2012 Elsevier B. V. All rights reserved.

语种英语
WOS记录号WOS:000311151100010
引用统计
被引频次:31[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/67232
专题北京大学药学院
作者单位1.Shandong Univ, Dept Pharmaceut, Coll Pharm, Jinan 250012, Peoples R China
2.Shandong Univ, Dept Nat Med Chem, Coll Pharm, Jinan 250012, Peoples R China
3.Peking Univ, State Key Lab Nat & Biomimet Drugs, Sch Pharmaceut Sci, Beijing 100083, Peoples R China
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Jia, Lejiao,Shen, Jingyi,Li, Zhenyu,et al. Successfully tailoring the pore size of mesoporous silica nanoparticles: Exploitation of delivery systems for poorly water-soluble drugs[J]. INTERNATIONAL JOURNAL OF PHARMACEUTICS,2012,439(1-2):81-91.
APA Jia, Lejiao.,Shen, Jingyi.,Li, Zhenyu.,Zhang, Dianrui.,Zhang, Qiang.,...&Tian, Xiaona.(2012).Successfully tailoring the pore size of mesoporous silica nanoparticles: Exploitation of delivery systems for poorly water-soluble drugs.INTERNATIONAL JOURNAL OF PHARMACEUTICS,439(1-2),81-91.
MLA Jia, Lejiao,et al."Successfully tailoring the pore size of mesoporous silica nanoparticles: Exploitation of delivery systems for poorly water-soluble drugs".INTERNATIONAL JOURNAL OF PHARMACEUTICS 439.1-2(2012):81-91.
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