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学科主题: 药学
题名:
Successfully tailoring the pore size of mesoporous silica nanoparticles: Exploitation of delivery systems for poorly water-soluble drugs
作者: Jia, Lejiao1; Shen, Jingyi1; Li, Zhenyu2; Zhang, Dianrui1; Zhang, Qiang3; Duan, Cunxian1; Liu, Guangpu1; Zheng, Dandan1; Liu, Yue1; Tian, Xiaona1
关键词: Mesoporous silica nanoparticles ; Pore sizes ; Paclitaxel ; Poor water solubility ; In vitro anti-tumor
刊名: INTERNATIONAL JOURNAL OF PHARMACEUTICS
发表日期: 2012-12-15
DOI: 10.1016/j.ijpharm.2012.10.011
卷: 439, 期:1-2, 页:81-91
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Pharmacology & Pharmacy
研究领域[WOS]: Pharmacology & Pharmacy
关键词[WOS]: POLYMERIC MICELLES ; CONTROLLED-RELEASE ; ANTICANCER DRUGS ; NANOCRYSTALS ; NANOEMULSION ; FORMULATION ; ENDOCYTOSIS ; PACLITAXEL ; EFFICACY ; CARRIERS
英文摘要:

A novel approach was applied to fabricate mesoporous silica nanoparticles (MSNs) with different pore size in this study. The pore size of MSNs can be modulated conveniently from 3 nm to 10 nm by controlling the etching time of MSNs with the NaBH4 solution. The as-synthesized MSNs were investigated as carriers for loading and delivery of the model drug paclitaxel (PTX). The characteristics, drug loading capacity, in vitro drug release behavior, anti-tumor activity and the mechanism of cell uptake were systematically studies. The resultant MSNs showed uniform and mono-dispersed sphere with high drug loading capacity (12-21%). The in vitro drug release exhibited that the released rate of PTX from MSNs could be controlled by the pore size and the larger the pore size, the faster the release rate of PTX. The in vitro anti-tumor studies demonstrated that PTX-loaded MSNs produced higher cytotoxicity than free PTX. Besides, the PTX-loaded MSNs with largest pore size showed the highest anti-tumor activity. These results indicated that these MSNs could provide a promising platform for delivering water-insoluble drugs, controlling the release rate of drugs and increasing the anti-tumor activity. (C) 2012 Elsevier B. V. All rights reserved.

语种: 英语
所属项目编号: 2009CB930300
项目资助者: National Basic Research Program of China (973 Program)
WOS记录号: WOS:000311151100010
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/67232
Appears in Collections:北京大学药学院_期刊论文

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作者单位: 1.Shandong Univ, Dept Pharmaceut, Coll Pharm, Jinan 250012, Peoples R China
2.Shandong Univ, Dept Nat Med Chem, Coll Pharm, Jinan 250012, Peoples R China
3.Peking Univ, State Key Lab Nat & Biomimet Drugs, Sch Pharmaceut Sci, Beijing 100083, Peoples R China

Recommended Citation:
Jia, Lejiao,Shen, Jingyi,Li, Zhenyu,et al. Successfully tailoring the pore size of mesoporous silica nanoparticles: Exploitation of delivery systems for poorly water-soluble drugs[J]. INTERNATIONAL JOURNAL OF PHARMACEUTICS,2012,439(1-2):81-91.
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