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Association of asymptomatic oral candidal carriage, oral candidiasis and CD4(+) lymphocyte count in HIV-positive patients in China
Liu, X; Liu, H; Guo, Z; Luan, W
关键词HIV oral candidiasis asymptomatic oral candidal carriage CD4(+) lymphocyte
刊名ORAL DISEASES
2006
DOI10.1111/j.1601-0825.2005.01155.x
12期:1页:41-44
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Dentistry, Oral Surgery & Medicine
研究领域[WOS]Dentistry, Oral Surgery & Medicine
关键词[WOS]PREDISPOSING FACTORS ; INFECTION ; ALBICANS ; LESIONS ; OROPHARYNGEAL ; PREVALENCE
英文摘要

OBJECTIVES: To compare the prevalence of asymptomatic oral candidal carriage in healthy volunteers with human immunodeficiency virus (HIV)-positive patients in China, as well as to investigate the relationship between CD4(+) lymphocyte count and oral candidal colonization or oral candidiasis.

METHODS: Oral candidal carriage and oral candidiasis were investigated in 101 patients with HIV-infection seen at Youan Hospital, Beijing, China. Two hundred and seventeen healthy volunteers were involved as a control. Culture from saliva was used to test for the presence of oral Candida. CD4(+) lymphocyte count was measured by flow cytometry. All data were analyzed statistically by SAS.

RESULTS: Asymptomatic oral candidal carriage rate (28.6%) in HIV-positive group was similar to that in the healthy group (18.0%; P = 0.07). No significant difference in CD4(+) lymphocyte count was found between oral Candida carriers and non-carriers among HIV-positive subjects (P = 0.89). However, the frequency of oral candidiasis increased with the decrease in CD4(+) lymphocyte count (P < 0.0001), and pseudomembranous candidiasis was predominant in HIV-positive patients with CD4(+) < 200 cells mu l(-1) (66.7%).

CONCLUSIONS: In HIV-positive subjects, asymptomatic oral candidal colonization is not related to CD4(+) lymphocyte count of blood, and the carriage rate is similar to that in the healthy population. Oral candidiasis is more likely to be observed in HIV-positive patients who have a low CD4(+) lymphocyte count.

语种英语
WOS记录号WOS:000234405300005
引用统计
被引频次:14[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/67237
专题北京大学口腔医学院
作者单位1.Beijing Hosp, Dept Dent, Beijing 100730, Peoples R China
2.Peking Univ, Sch Stomatol, Beijing 100871, Peoples R China
推荐引用方式
GB/T 7714
Liu, X,Liu, H,Guo, Z,et al. Association of asymptomatic oral candidal carriage, oral candidiasis and CD4(+) lymphocyte count in HIV-positive patients in China[J]. ORAL DISEASES,2006,12(1):41-44.
APA Liu, X,Liu, H,Guo, Z,&Luan, W.(2006).Association of asymptomatic oral candidal carriage, oral candidiasis and CD4(+) lymphocyte count in HIV-positive patients in China.ORAL DISEASES,12(1),41-44.
MLA Liu, X,et al."Association of asymptomatic oral candidal carriage, oral candidiasis and CD4(+) lymphocyte count in HIV-positive patients in China".ORAL DISEASES 12.1(2006):41-44.
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