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学科主题: 临床医学
题名:
Increased SOX2 expression in less differentiated breast carcinomas and their lymph node metastases
作者: Huang, Yu-Hua1; Luo, Ming-Hua2; Ni, Yun-Bi3; Tsang, Julia Y. S.3; Chan, Siu-Ki4; Lui, Philip C. W.5; Yu, Alex M. C.5; Tan, Puay-Hoon6; Tse, Gary M.3
关键词: breast cancer ; cancer stem cell ; immunohistochemistry ; SOX2
刊名: HISTOPATHOLOGY
发表日期: 2014-03-01
DOI: 10.1111/his.12257
卷: 64, 期:4, 页:494-503
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Cell Biology ; Pathology
研究领域[WOS]: Cell Biology ; Pathology
关键词[WOS]: STEM-CELLS ; NONSMALL CELL ; CANCER ; MARKER ; SUBTYPES ; STAGE
英文摘要:

AimsSOX2 is a key regulatory gene in embryonic stem cells. Although it has been implicated in cancer progression, its role in breast carcinoma is poorly understood.

Materials and methodsFifty-seven ductal carcinomas in situ (DCIS), 552 invasive breast carcinomas and 107 corresponding metastatic lymph nodes were evaluated immunohistochemically for the expression of SOX2. Its correlation with clinicopathological features, other biomarker profiles and patients′ outcomes were analysed.

ResultsSOX2 was detected in 19.0% (105 of 552) of invasive breast carcinomas and 12.3% (seven of 57) of DCIS. Expression correlated with larger tumour size (P=0.005) and higher grade (P=0.002). It was associated negatively with ER (P=0.015) and PR (P=0.046) expression, but positively with Ki67 index (P=0.013). Interestingly, it was also associated with neuroendocrine marker expression (synpatophysin and chromogranin/synaptophysin, P=0.048 and 0.028, respectively). Expression appeared to be independent from that of common stem cell markers, namely CD44, CD24 and aldehyde dehydrogenase 1 (ALDH1). Furthermore, a higher rate of expression was observed in metastatic lymph nodes than in the corresponding primary tumours (P=0.034). High SOX2 expression was correlated with poor disease-free survival (log-rank=9.489, P=0.012) and was an independent prognostic factor (HR=2.918, P=0.015) in patients with high nodal stages.

ConclusionsIn summary, SOX2 expression was related to adverse breast carcinoma profile and poor outcome in selected patient groups.

语种: 英语
WOS记录号: WOS:000331249800004
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/67238
Appears in Collections:北京大学深圳医院_病理科_期刊论文

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作者单位: 1.Kwong Wah Hosp, Dept Pathol, Hong Kong, Hong Kong, Peoples R China
2.Shenzhen Second People Hosp, Dept Pathol, Shenzhen, Peoples R China
3.Peking Univ, Shenzhen Hosp, Dept Pathol, Shenzhen, Peoples R China
4.Chinese Univ Hong Kong, Prince Wales Hosp, Dept Anat & Cellular Pathol, Hong Kong, Hong Kong, Peoples R China
5.Union Hosp, Dept Pathol, Hong Kong, Hong Kong, Peoples R China
6.Singapore Gen Hosp, Dept Pathol, Singapore, Singapore

Recommended Citation:
Huang, Yu-Hua,Luo, Ming-Hua,Ni, Yun-Bi,et al. Increased SOX2 expression in less differentiated breast carcinomas and their lymph node metastases[J]. HISTOPATHOLOGY,2014,64(4):494-503.
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