IR@PKUHSC  > 北京大学第一临床医学院  > 儿科
学科主题临床医学
Effect of L-arginine on collagen of high flow-induced pulmonary arterial remodeling
Du, JB; Yan, H; Wei, B; Qi, JG; Tang, CS
关键词collagen L-arginine pulmonary hypertension
刊名CIRCULATION JOURNAL
2005-05-01
69期:5页:603-608
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Cardiac & Cardiovascular Systems
研究领域[WOS]Cardiovascular System & Cardiology
关键词[WOS]MUSCLE CELL-MIGRATION ; SMOOTH-MUSCLE ; RAT ; PROLIFERATION ; EXPRESSION
英文摘要

Background Pulmonary hypertension (PH) is a common complication of congenital heart disease and pulmonary vascular structural remodeling due to the high pulmonary blood flow is considered as the key pathologic process. In the present study the effects of L-arginine on the collagen metabolism of pulmonary arteries in rats with high pulmonary blood flow-induced PH were investigated to elucidate its mechanism. Methods and Results The rat model of PH was established with an abdominal aorta and inferior vena cava shunt. L-arginine (1 g/kg per day) was given directly into the stomachs of the rats with the shunt (L-arginine+shunt group) and 11 weeks later, the pulmonary hemodynamics were studied. Collagen I and collagen III expressions were detected by immunohistochemical assay. The expressions of procollagen I mRNA, procollagen III mRNA, the tissue inhibitor of metalloproteinase-1 mRNA and the matrix metalloproteinase-1 mRNA were detected by in situ hybridization. The expressions of pulmonary artery collagen 1, collagen III, procollagen I mRNA and procollagen III mRNA in the shunt rats were obviously elevated compared with the control rats (p < 0.01). The positive signals were mainly located in the media and adventitia of median and small pulmonary arteries. The expressions of the pulmonary artery tissue inhibitor of metalloproteinase-1 mRNA, metalloproteinase-1 mRNA and the ratio of tissue inhibitor of metalloproteinase-1/metalloproteinase-1 were elevated in the shunt rats (p < 0.01). However, the expressions of pulmonary artery collagen 1, collagen III, procollagen I mRNA and procollagen III mRNA were significantly reduced in the shunt rats of the L-arginine group (p < 0.01). L-arginine also downregulated the expressions of tissue inhibitor of metalloproteinase-1 mRNA and metalloproteinase-1 mRNA, as well as the ratio of tissue inhibitor of metalloproteinase-1/metalloproteinase-1 (p < 0.05). Conclusions L-arginine can reduce the synthesis of extracellular matrix-collagen and increase its degradation, thus having an important modulating effect on pulmonary vascular matrix remodeling induced by high pulmonary blood flow.

语种英语
WOS记录号WOS:000228765700015
引用统计
被引频次:12[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/67243
专题北京大学第一临床医学院_儿科
作者单位1.Peking Univ, Dept Pediat, 1st Hosp, Beijing, Peoples R China
2.Peking Univ, Dept Thorac Surg, 1st Hosp, Beijing, Peoples R China
3.Peking Univ, Inst Cardiovasc Res, 1st Hosp, Beijing, Peoples R China
4.Key Lab Mol Cardiovasc Sci, Minist Educ, Beijing, Peoples R China
推荐引用方式
GB/T 7714
Du, JB,Yan, H,Wei, B,et al. Effect of L-arginine on collagen of high flow-induced pulmonary arterial remodeling[J]. CIRCULATION JOURNAL,2005,69(5):603-608.
APA Du, JB,Yan, H,Wei, B,Qi, JG,&Tang, CS.(2005).Effect of L-arginine on collagen of high flow-induced pulmonary arterial remodeling.CIRCULATION JOURNAL,69(5),603-608.
MLA Du, JB,et al."Effect of L-arginine on collagen of high flow-induced pulmonary arterial remodeling".CIRCULATION JOURNAL 69.5(2005):603-608.
条目包含的文件
条目无相关文件。
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Du, JB]的文章
[Yan, H]的文章
[Wei, B]的文章
百度学术
百度学术中相似的文章
[Du, JB]的文章
[Yan, H]的文章
[Wei, B]的文章
必应学术
必应学术中相似的文章
[Du, JB]的文章
[Yan, H]的文章
[Wei, B]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。