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学科主题: 临床医学
题名:
Effect of L-arginine on collagen of high flow-induced pulmonary arterial remodeling
作者: Du, JB; Yan, H; Wei, B; Qi, JG; Tang, CS
关键词: collagen ; L-arginine ; pulmonary hypertension
刊名: CIRCULATION JOURNAL
发表日期: 2005-05-01
卷: 69, 期:5, 页:603-608
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Cardiac & Cardiovascular Systems
研究领域[WOS]: Cardiovascular System & Cardiology
关键词[WOS]: MUSCLE CELL-MIGRATION ; SMOOTH-MUSCLE ; RAT ; PROLIFERATION ; EXPRESSION
英文摘要:

Background Pulmonary hypertension (PH) is a common complication of congenital heart disease and pulmonary vascular structural remodeling due to the high pulmonary blood flow is considered as the key pathologic process. In the present study the effects of L-arginine on the collagen metabolism of pulmonary arteries in rats with high pulmonary blood flow-induced PH were investigated to elucidate its mechanism. Methods and Results The rat model of PH was established with an abdominal aorta and inferior vena cava shunt. L-arginine (1 g/kg per day) was given directly into the stomachs of the rats with the shunt (L-arginine+shunt group) and 11 weeks later, the pulmonary hemodynamics were studied. Collagen I and collagen III expressions were detected by immunohistochemical assay. The expressions of procollagen I mRNA, procollagen III mRNA, the tissue inhibitor of metalloproteinase-1 mRNA and the matrix metalloproteinase-1 mRNA were detected by in situ hybridization. The expressions of pulmonary artery collagen 1, collagen III, procollagen I mRNA and procollagen III mRNA in the shunt rats were obviously elevated compared with the control rats (p < 0.01). The positive signals were mainly located in the media and adventitia of median and small pulmonary arteries. The expressions of the pulmonary artery tissue inhibitor of metalloproteinase-1 mRNA, metalloproteinase-1 mRNA and the ratio of tissue inhibitor of metalloproteinase-1/metalloproteinase-1 were elevated in the shunt rats (p < 0.01). However, the expressions of pulmonary artery collagen 1, collagen III, procollagen I mRNA and procollagen III mRNA were significantly reduced in the shunt rats of the L-arginine group (p < 0.01). L-arginine also downregulated the expressions of tissue inhibitor of metalloproteinase-1 mRNA and metalloproteinase-1 mRNA, as well as the ratio of tissue inhibitor of metalloproteinase-1/metalloproteinase-1 (p < 0.05). Conclusions L-arginine can reduce the synthesis of extracellular matrix-collagen and increase its degradation, thus having an important modulating effect on pulmonary vascular matrix remodeling induced by high pulmonary blood flow.

语种: 英语
WOS记录号: WOS:000228765700015
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/67243
Appears in Collections:北京大学第一临床医学院_儿科_期刊论文

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作者单位: 1.Peking Univ, Dept Pediat, 1st Hosp, Beijing, Peoples R China
2.Peking Univ, Dept Thorac Surg, 1st Hosp, Beijing, Peoples R China
3.Peking Univ, Inst Cardiovasc Res, 1st Hosp, Beijing, Peoples R China
4.Key Lab Mol Cardiovasc Sci, Minist Educ, Beijing, Peoples R China

Recommended Citation:
Du, JB,Yan, H,Wei, B,et al. Effect of L-arginine on collagen of high flow-induced pulmonary arterial remodeling[J]. CIRCULATION JOURNAL,2005,69(5):603-608.
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