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学科主题: 临床医学
题名:
Prediction of recurrence risk in early breast cancer using human epidermal growth factor 2 and cyclin A2
作者: Li Hui-ping1; Ji Jia-fu4; Hou Kuan-yong2; Lei Yu-tao2; Zhao Hong-mei2; Wang Jing1; Zheng Jie3; Liu Jian-ying3; Wang Mo-pei1; Xiao Yu1; Wang You-fan1; Lu You-yong4; Sun Yan5
关键词: breast neoplasms ; cyclin A2 ; human epidermal growth factor 2, prognosis
刊名: CHINESE MEDICAL JOURNAL
发表日期: 2010-02-20
DOI: 10.3760/cma.j.issn.0366-6999.2010.04.009
卷: 123, 期:4, 页:431-437
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Medicine, General & Internal
研究领域[WOS]: General & Internal Medicine
关键词[WOS]: GENE AMPLIFICATION ; CHEMOTHERAPY RESPONSE ; PROGNOSTIC VALUE ; EXPRESSION ; CARCINOMA ; CELLS ; HER2 ; OVEREXPRESSION ; PATIENT ; ARREST
英文摘要:

Background Human epidermal growth factor 2 (HER2) is one of the most important prediction factors, but only 25%-30% of breast cancer patients HER2 are positive. It is unknown whether there are other molecular markers that could be used to predict prognosis and recurrence in HER2 negative patients This study investigated correlations of cyclin A2 and HER2 levels with clinical outcomes in 281 patients with invasive breast cancer in order to identify whether cyclin A2 can serve as a prognostic factor in HER2 negative patients.

Methods Immunohistochemical staining was used to detect cyclin A2 and HER2 expression in 281 patients Cyclin A2 and HER2 gene amplifications were analyzed using gene analysis and RT-PCR in 12 patients Risk and survival estimates were analyzed using Log-rank, Kaplan-Meier, and Cox regression analysis; cyclin A2 and HER2 consistency with survival were analyzed using Kappa analysis

Results Patients with higher cyclin A2 and HER2 expressions had significantly shorter disease-free survival periods (P=0 047 and P=0 05, respectively) Kappa analysis performed that cyclin A2 and HER2 showed a low Kappa index (kappa=0 37), allowing us to conclude that cyclin A2 and HER2 detect different pathologies Gene analysis and RT-PCR showed that cyclin A2 was upregulated in patients with early relapse, the average increase was 3 69-2 74 fold

Conclusions Cyclin A2 and HER2 are associated with proliferation and high recurrence, particularly when combined Cyclin A2 is easily detected by nuclear staining and might be a useful biomarker for recurrence risk in HER2 negative patients Chin Med J 2010,123(4) 431-437

语种: 英语
所属项目编号: 30672424 ; 30471684
项目资助者: National Natural Science Foundation of China
WOS记录号: WOS:000275048100009
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/67246
Appears in Collections:北京大学第三临床医学院_肿瘤放疗科_期刊论文

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作者单位: 1.Peking Univ, Hosp 3, Dept Surg, Beijing 100191, Peoples R China
2.Peking Univ, Hosp 3, Dept Med Oncol, Beijing 100191, Peoples R China
3.Peking Univ, Hosp 3, Dept Pathol, Beijing 100191, Peoples R China
4.Peking Univ, Sch Oncol, Beijing Canc Hosp, Dept Surg, Beijing 100036, Peoples R China
5.Chinese Acad Med Sci, Canc Inst & Hosp, Dept Med Oncol, Beijing 100021, Peoples R China

Recommended Citation:
Li Hui-ping,Ji Jia-fu,Hou Kuan-yong,et al. Prediction of recurrence risk in early breast cancer using human epidermal growth factor 2 and cyclin A2[J]. CHINESE MEDICAL JOURNAL,2010,123(4):431-437.
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