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学科主题: 基础医学
题名:
The effect of topiramate on tumor-related angiogenesis and on the serum proteome of mice bearing Lewis lung carcinoma
作者: Ma, Bing1,2; Pan, Yan1,2; Song, Qianliu1,2; Tie, Lu1,2; Zhang, Ye1,2; Xiao, Yuan1,2; Zhang, Jianzhao1,2; Han, Jing1,2; Xu, Yan1,2; Xiang, Yang1,2; Yu, He-Ming3; Li, Xue-Jun1,2
关键词: Tumor metastasis ; Angiogenesis ; Topiramate ; Osteopontin ; VEGF ; Carbonic anhydrase II
刊名: EUROPEAN JOURNAL OF PHARMACOLOGY
发表日期: 2011-08-01
DOI: 10.1016/j.ejphar.2011.04.056
卷: 663, 期:1-3, 页:9-16
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Pharmacology & Pharmacy
研究领域[WOS]: Pharmacology & Pharmacy
关键词[WOS]: ENDOTHELIAL GROWTH-FACTOR ; CARBONIC-ANHYDRASE-IX ; RENAL-CELL CARCINOMA ; BRAIN-TUMORS ; OSTEOPONTIN ; CANCER ; METASTASIS ; INHIBITION ; EXPRESSION ; EPILEPSY
英文摘要:

Topiramate has been used in patients with brain tumors who develop epilepsy. In our previous research we found topiramate could inhibit tumor metastases of Lewis lung carcinoma in C57BL/6 mice. In this study we aimed to assess the antimetastatic activity of topiramate and determine its mechanism of action. After confirming the effects of topiramate on Lewis lung carcinoma in C57BL/6 mice, we assessed the mRNA expression of carbonic anhydrases II and IX, and the vascular endothelial growth factor (VEGF) distribution in tumor tissue. We studied the role of topiramate on primary angiogenesis using a chicken embryo chorioallantoic membrane angiogenesis model, and analyzed the protein profile of serum from mice treated with or without topiramate by two-dimensional electrophoresis. We found that topiramate significantly reduced the primary tumor growth (P<0.05) and the degree of damage to the lung alveoli caused by metastatic tumor deposits. The two-dimensional electrophoresis revealed changes that occurred with topiramate treatment and four down-regulated protein spots were clearly identified as tropomyosin, osteopontin, transthyretin, and serum amyloid A-1. The mRNA and protein expression of serum amyloid A-1, osteopontin and its receptor, integrin alpha(v)beta(3) in tumor tissue were reconfirmed. The results suggest that topiramate has antitumor and antimetastatic effects on Lewis lung carcinoma. Its mechanism of action may be related to its inhibition of angiogenesis by down-regulation of osteopontin, VEGF and carbonic anhydrase II. (C) 2011 Elsevier B.V. All rights reserved.

语种: 英语
WOS记录号: WOS:000292431700002
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/67249
Appears in Collections:基础医学院_药理学系_期刊论文

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作者单位: 1.Peking Univ, Inst Syst Biomed, Beijing 100191, Peoples R China
2.Peking Univ, Sch Basic Med Sci, Dept Pharmacol, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China
3.Natl Res Inst Family Planning, Beijing 100081, Peoples R China

Recommended Citation:
Ma, Bing,Pan, Yan,Song, Qianliu,et al. The effect of topiramate on tumor-related angiogenesis and on the serum proteome of mice bearing Lewis lung carcinoma[J]. EUROPEAN JOURNAL OF PHARMACOLOGY,2011,663(1-3):9-16.
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