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Synthesis of multivalent N-acetyl lactosamine modified quantum dots for the study of carbohydrate and galectin-3 interactions
Yang, Yang1; Xue, Xiao-Chao1; Jin, Xiao-Feng1; Wang, Li-Jun2,3; Sha, Yin-Lin2,3; Li, Zhong-Jun1
关键词Glyco-quantum dots NMR SPR Galectin-3 N-Acetyl lactosamine Cluster effect
刊名TETRAHEDRON
2012-09-02
DOI10.1016/j.tet.2012.06.035
68期:35页:7148-7154
收录类别SCI ; IC
文章类型Article
WOS标题词Science & Technology
类目[WOS]Chemistry, Organic
研究领域[WOS]Chemistry
关键词[WOS]CHEMICAL PROBE ; BINDING ; NANOCRYSTALS ; INHIBITORS ; GLYCONANOPARTICLES ; DERIVATIVES ; MODEL ; COLI
英文摘要

Ternary core/shell CdSeS/ZnS-QDs coated with N-acetyl lactosamine was prepared as a fluorescent probe to study the interactions of N-acetyl lactosamine and galectin-3. The synthesis of N-acetyl lactosamine was achieved through the ′azidoiodoglycosylation′ method. The amount of ligand coated on QDs was determined by H-1 NMR and ICP-OES. The interactions between carbohydrates and galectin-3 were measured using SPR. The results revealed that the affinity of galectin-3 with di- and multivalent N-acetyl lactosamine increased 20 and 184-fold, respectively. The prepared glyco-QDs could be used as an efficient fluorescent probe to study carbohydrates and galectin-3 interactions. (C) 2012 Elsevier Ltd. All rights reserved.

语种英语
WOS记录号WOS:000307126700019
项目编号90713004 ; 20732001 ; 2009ZX09103-044 ; 2009ZX09501-011 ; 2012CB822100
资助机构Natural Science Foundation of China ; State New Drug Innovation ; National Basic Research Program of China ; State Key Laboratory of Natural and Biomimetic Drugs and Peking University
引用统计
被引频次:13[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/67251
专题北京大学药学院
北京大学基础医学院
北京大学药学院_化学生物学系
作者单位1.Peking Univ, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China
2.Peking Univ, Sch Basic Med Sci, Dept Biophys, Single Mol & Nanobiol Lab, Beijing 100191, Peoples R China
3.Peking Univ, Biomed X Ctr, Beijing 100191, Peoples R China
推荐引用方式
GB/T 7714
Yang, Yang,Xue, Xiao-Chao,Jin, Xiao-Feng,et al. Synthesis of multivalent N-acetyl lactosamine modified quantum dots for the study of carbohydrate and galectin-3 interactions[J]. TETRAHEDRON,2012,68(35):7148-7154.
APA Yang, Yang,Xue, Xiao-Chao,Jin, Xiao-Feng,Wang, Li-Jun,Sha, Yin-Lin,&Li, Zhong-Jun.(2012).Synthesis of multivalent N-acetyl lactosamine modified quantum dots for the study of carbohydrate and galectin-3 interactions.TETRAHEDRON,68(35),7148-7154.
MLA Yang, Yang,et al."Synthesis of multivalent N-acetyl lactosamine modified quantum dots for the study of carbohydrate and galectin-3 interactions".TETRAHEDRON 68.35(2012):7148-7154.
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