IR@PKUHSC  > 北京大学第一临床医学院  > 心血管内科
学科主题临床医学
Changes in production and metabolism of brain natriuretic peptide in rats with myocardial necrosis
Jiang, W; Cai, DY; Pan, CS; Qi, YF; Jiang, HF; Geng, B; Tang, CS
关键词brain natriuretic peptide corin neutral endopeptidase myocardial necrosis
刊名EUROPEAN JOURNAL OF PHARMACOLOGY
2005-01-10
DOI10.1016/j.ejphar.2004.11.023
507期:1-3页:153-162
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Pharmacology & Pharmacy
研究领域[WOS]Pharmacology & Pharmacy
关键词[WOS]NEUTRAL ENDOPEPTIDASE ; GENE-EXPRESSION ; SERINE-PROTEASE ; HEART-FAILURE ; CORIN GENE ; DISEASE ; FURIN ; CARDIOMYOCYTES ; ADRENOMEDULLIN ; ISOPROTERENOL
英文摘要

In this study, we employed rat model of acute myocardial necrosis induced by isoproterenol (ISO) to study the possible roles of corin, the protease uniquely distributing in myocardium to convert pro-brain natriuretic peptide (proBNP) to BNP, and neutral endopeptidase (NEP), the major enzyme to degrade BNP, in changing the levels of BNP. In rats with isoproterenol alone, the myocardium necrosis occurred and the cardiac function was inhibited; the BNP contents in plasma and myocardium were upreagulated, so did the myocardial corin mRNA level; the NEP activity in plasma and myocardium were downregulated. Omapatrilat (OMA) treatment relieved myocardial lesions and improved cardiac function. In the plasma and myocardium, omapatrilat treatment increased BNP contents. reduced NEP activity; in myocardium. mRNA level of proBNP and corin decreased, but NEP mRNA expression increased. Our study confirmed that omapatrilat treated myocardial necrosis effectively and suggested that increased BNP in rats with myocardial necrosis could depend on increased production and conversion as well as decreased degradation. (C) 2004 Elsevier B.V. All rights reserved.

语种英语
WOS记录号WOS:000226715800019
Citation statistics
Cited Times:18[WOS]   [WOS Record]     [Related Records in WOS]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/67252
Collection北京大学第一临床医学院_心血管内科
作者单位1.Peking Univ, First Hosp, Inst Cardiovasc Dis, Beijing 100034, Peoples R China
2.Peking Univ, Hlth Sci Ctr, Dept Physiol, Beijing 100083, Peoples R China
3.Reference Lab Cardiovasc Mol Biol & Regulatory Pe, Minist Hlth, Beijing 100083, Peoples R China
Recommended Citation
GB/T 7714
Jiang, W,Cai, DY,Pan, CS,et al. Changes in production and metabolism of brain natriuretic peptide in rats with myocardial necrosis[J]. EUROPEAN JOURNAL OF PHARMACOLOGY,2005,507(1-3):153-162.
APA Jiang, W.,Cai, DY.,Pan, CS.,Qi, YF.,Jiang, HF.,...&Tang, CS.(2005).Changes in production and metabolism of brain natriuretic peptide in rats with myocardial necrosis.EUROPEAN JOURNAL OF PHARMACOLOGY,507(1-3),153-162.
MLA Jiang, W,et al."Changes in production and metabolism of brain natriuretic peptide in rats with myocardial necrosis".EUROPEAN JOURNAL OF PHARMACOLOGY 507.1-3(2005):153-162.
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