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学科主题: 临床医学
题名:
High Levels of Activin A Detected in Preeclamptic Placenta Induce Trophoblast Cell Apoptosis by Promoting Nodal Signaling
作者: Yu, Ling1,4; Li, Dong1,4; Liao, Qin-ping3; Yang, Hui-xia3; Cao, Bin1,4; Fu, Guodong2; Ye, Gang2; Bai, Yang1,4; Wang, Hao1,4; Cui, Nana1; Liu, Ming1; Li, Yu-xia1; Li, Jun5; Peng, Chun2; Wang, Yan-ling1
刊名: JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
发表日期: 2012-08-01
DOI: 10.1210/jc.2011-2729
卷: 97, 期:8, 页:E1370-E1379
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Endocrinology & Metabolism
研究领域[WOS]: Endocrinology & Metabolism
关键词[WOS]: CANCER CELLS ; INHIBIN-A ; CIRCULATING LEVELS ; GROWTH-INHIBITION ; SERUM-LEVELS ; KINASE ; RECEPTORS ; SECRETION ; PREGNANCY ; PROTEIN
英文摘要:

Context: The pregnancy-specific disorder preeclampsia is a major cause of maternal mortality and morbidity. Activin A has been suggested as a potential biomarker of the disease, but whether it plays a role in the pathology of preeclampsia or is just a manifestation of the disease is not fully understood.

Objective: The objective of the study was to examine the roles of ActivinAon placental trophoblast cells under pathological conditions of preeclampsia.

Design: Placental and plasma productions of ActivinAin healthy pregnant women and preeclamptic patients were compared by using clinical samples obtained from Peking University First Hospital during November 2005 to November 2007. The role of Activin A at pathological doses was investigated in human trophoblast cells.

Results: Plasma and placental productions of Activin A were significantly higher in preeclamptic patients when compared with normal pregnant subjects in a Chinese Han population. Treatment of trophoblast cells with high doses of Activin A resulted in a significant increase in cell apoptosis. This effect was blocked not only by silencing Activin A′s receptor activin receptor-like kinase 4 but also by knockdown of Nodal′s receptor ALK7. Important to note was that Activin A could significantly increase Nodal expression in trophoblast cells, and knockdown of Nodal resulted in evident blockage on Activin A-induced trophoblast cell apoptosis.

Conclusion: High levels of Activin A observed in preeclamptic placenta may play a role in the pathogenesis of preeclampsia by inducing excessive apoptosis in placenta indirectly through enhancing Nodal expression. (J Clin Endocrinol Metab 97: E1370-E1379, 2012)

语种: 英语
所属项目编号: 2011CB944400 ; 81025004 ; 3081120430 ; MOP-81370 ; CCI-92222
项目资助者: Chinese National Special Fund ; National Natural Sciences Foundation ; Canadian Institutes for Health Research ; Canadian Institutes for Health Research/Ontario Women&prime ; s Health Council
WOS记录号: WOS:000307457400004
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/67253
Appears in Collections:北京大学第一临床医学院_期刊论文

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作者单位: 1.York Univ, Dept Biol, Toronto, ON M3J 1P3, Canada
2.Chinese Acad Sci, State Key Lab Reprod Biol, Inst Zool, Beijing 100101, Peoples R China
3.Peking Univ, Hosp 1, Dept Obstet & Gynecol, Beijing 100034, Peoples R China
4.Chinese Acad Sci, Grad Sch, Beijing 100049, Peoples R China
5.China Med Univ, Dept Obstet & Gynecol, Hosp 2, Shenyang 110004, Peoples R China

Recommended Citation:
Yu, Ling,Li, Dong,Liao, Qin-ping,et al. High Levels of Activin A Detected in Preeclamptic Placenta Induce Trophoblast Cell Apoptosis by Promoting Nodal Signaling[J]. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM,2012,97(8):E1370-E1379.
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