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Soy isoflavone intake inhibits bone resorption and stimulates bone formation in menopausal women: meta-analysis of randomized controlled trials
Ma, D-F1,2; Qin, L-Q3; Wang, P-Y1; Katoh, R.2
关键词soy isoflavone osteoporosis bone metabolism deoxypyridinoline bone-specific alkaline phosphatase
刊名EUROPEAN JOURNAL OF CLINICAL NUTRITION
2008-02-01
DOI10.1038/sj.ejcn.1602748
62期:2页:155-161
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Nutrition & Dietetics
研究领域[WOS]Nutrition & Dietetics
关键词[WOS]HORMONE-REPLACEMENT THERAPY ; PLACEBO-CONTROLLED TRIAL ; POSTMENOPAUSAL WOMEN ; DOUBLE-BLIND ; DIETARY PHYTOESTROGENS ; PREMENOPAUSAL WOMEN ; SOYBEAN ISOFLAVONES ; LDL CHOLESTEROL ; MINERAL DENSITY ; PHYTO-ESTROGENS
英文摘要

Objective: To clarify the effects of isoflavone intake on bone resorption and bone formation.

Methods: We identified randomized controlled trials related to urinary deoxypyridinoline (Dpyr, a bone resorption marker) and serum bone-specific alkaline phosphatase (BAP, a bone formation marker) listed on MEDLINE (January 1966-April 2006), the Cochrane Controlled Trials Register, EMBASE (1985-January 2006), Science Citation Index and PUBMED (updated till April 2006).

Results: Nine studies with a total of 432 subjects were selected for meta-analysis. The urinary Dpyr concentration in subjects who consumed isoflavones decreased significantly by -2.08 nmol/mmol (95% confidence interval (CI): -3.82 to -0.34 nmol/mmol) in comparison with that in subjects who did not consume isoflavones. Isoflavone intake vs placebo intake significantly increased serum BAP by 1.48 mu g/l (95% CI: 0.22-2.75 mu g/l). Decreases in the urinary Dpyr concentration with isoflavone intake of <90 mg/day and with treatment lasting less than 12 weeks were -2.34 nmol/mmol (95% CI:-4.46 to -0.22 nmol/mmol) and -2.03 nmol/mmol (95% CI: -3.20 to -0.85 nmol/mmol), respectively.

Conclusions: Isoflavone intervention significantly inhibits bone resorption and stimulates bone formation. These favorable effects occur even if <90 mg/day of isoflavones are consumed or the intervention lasts less than 12 weeks.

语种英语
WOS记录号WOS:000252932900001
引用统计
被引频次:87[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/67254
专题北京大学公共卫生学院
作者单位1.Peking Univ, Sch Publ Hlth, Dept Social Med & Hlth Educ, Beijing, Peoples R China
2.Univ Yamanashi, Interdisciplinary Grad Sch Med & Engn, Dept Human Pathol, Yamanashi, Japan
3.Soochow Univ, Sch Radiat Med & Publ Hlth, Dept Nutr & Food Hyg, Suzhou, Peoples R China
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GB/T 7714
Ma, D-F,Qin, L-Q,Wang, P-Y,et al. Soy isoflavone intake inhibits bone resorption and stimulates bone formation in menopausal women: meta-analysis of randomized controlled trials[J]. EUROPEAN JOURNAL OF CLINICAL NUTRITION,2008,62(2):155-161.
APA Ma, D-F,Qin, L-Q,Wang, P-Y,&Katoh, R..(2008).Soy isoflavone intake inhibits bone resorption and stimulates bone formation in menopausal women: meta-analysis of randomized controlled trials.EUROPEAN JOURNAL OF CLINICAL NUTRITION,62(2),155-161.
MLA Ma, D-F,et al."Soy isoflavone intake inhibits bone resorption and stimulates bone formation in menopausal women: meta-analysis of randomized controlled trials".EUROPEAN JOURNAL OF CLINICAL NUTRITION 62.2(2008):155-161.
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