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学科主题: 公共卫生
题名:
NaGdF4 Nanoparticle-Based Molecular Probes for Magnetic Resonance Imaging of Intraperitoneal Tumor Xenografts in Vivo
作者: Hou, Yi1; Qiao, Ruirui1; Fang, Fang2; Wang, Xuxia2; Dong, Chengyan3; Liu, Kan4,5; Liu, Chunyan1; Liu, Zhaofei3; Lei, Hao2; Wang, Fan3; Gao, Mingyuan1
关键词: NaGdF4 nanoparticles ; ligand exchange ; T1 contrast agent ; MR molecular imaging probe ; intraperitoneal tumor xenografts
刊名: ACS NANO
发表日期: 2013
DOI: 10.1021/nn304837c
卷: 7, 期:1, 页:330-338
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Chemistry, Multidisciplinary ; Chemistry, Physical ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary
研究领域[WOS]: Chemistry ; Science & Technology - Other Topics ; Materials Science
关键词[WOS]: MRI CONTRAST AGENTS ; GOLD NANOPARTICLES ; GADOLINIUM ; NANOCRYSTALS ; CANCER ; NANOPROBES ; ANTIBODY
英文摘要:

Differently sized NaGdF4 nanocrystals with narrow particle size distributions were synthesized by a high temperature approach. Upon ligand exchange, the as-prepared hydrophobic NaGdF4 nanocrystals were transferred into water by using asymmetric PEGs simultaneously bearing phosphate and maleimide groups. Further investigations demonstrated that the water-soluble NaGdF4 nanocrystals, coated by PEG bearing two phosphate groups on the same side, exhibit not only excellent colloidal stability in water and PBS buffer, but also higher T1 relaxivity than Gd-DTPA (Magnevist). Through "click" reaction between the maleimide residue on particle surface and thiol group from the partly reduced anti-EGFR monoclonal antibody (mAb), NaGdF4 PEG-mAb nanoprobes were constructed, and their biocompatibility and binding specificity were evaluated through in vitro experiments. A series of in vivo experiments were then carried out for detecting Intraperitoneal tumor xenografts in nude mice by using magnetic resonance (MR) imaging technique. The results revealed that the NaGdF4 PEG-mAb probes possessed satisfying tumor-specific targeting ability and strong MR contrast enhancement effects.

语种: 英语
所属项目编号: 2011CB935800 ; 81090271 ; 21003135 ; 20820102035 ; 21021003 ; KJCX2-YW-M15
项目资助者: National Basic Research Program of China ; NSFC ; CAS
WOS记录号: WOS:000314082800037
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/67256
Appears in Collections:北京大学医药卫生分析中心_期刊论文

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作者单位: 1.Chinese Acad Sci, Inst Chem, Beijing 100190, Peoples R China
2.Chinese Acad Sci, Wuhan Ctr Magnet Resonance, State Key Lab Magnet Resonance & Atom & Mol Phys, Wuhan Inst Phys & Math, Wuhan 430071, Peoples R China
3.Peking Univ, Med Isotopes Res Ctr, Beijing 100083, Peoples R China
4.CAMS, Canc Hosp, Beijing 100021, Peoples R China
5.PUMC, Beijing 100021, Peoples R China

Recommended Citation:
Hou, Yi,Qiao, Ruirui,Fang, Fang,et al. NaGdF4 Nanoparticle-Based Molecular Probes for Magnetic Resonance Imaging of Intraperitoneal Tumor Xenografts in Vivo[J]. ACS NANO,2013,7(1):330-338.
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