北京大学医学部机构知识库
Advanced  
IR@PKUHSC  > 北京大学第一临床医学院  > 期刊论文
学科主题: 临床医学
题名:
Measurement of D-dimer as aid in risk evaluation of VTE in elderly patients hospitalized for acute illness: A prospective, multicenter study in China
作者: Fan, Jin1; Li, Xiaoying1; Cheng, Youqin1; Yao, Chen2; Zhong, Nanshan3; In Estigators Grp
刊名: CLINICAL AND INVESTIGATIVE MEDICINE
发表日期: 2011
卷: 34, 期:2, 页:E96-E104
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Medicine, Research & Experimental
研究领域[WOS]: Research & Experimental Medicine
关键词[WOS]: DEEP-VEIN THROMBOSIS ; PREDICT VENOUS THROMBOEMBOLISM ; ILL MEDICAL PATIENTS ; PULMONARY-EMBOLISM ; ANTICOAGULATION ; THROMBOPHILIA ; PREVENTION ; PLACEBO
英文摘要:

Purpose: Advanced age and hospitalization are associated with increasing risk of venous thromboembolic (VTE) events. The aim of this study was to investigate whether elevated D-dimer levels could predict VTE events in elderly patients hospitalized for acute illness.

Methods: 458 consecutive patients (65% men; mean age, 77 +/- 7 years) who were older than 60 years, immobilized for >= 3 days, and hospitalized for heart failure, respiratory failure, acute ischemic stroke, or acute infectious disease without pharmacological prophylaxis or recent major surgery, were enrolled. Elevated D-dimer levels were defined as > 500 ng/ml. VTE events included symptomatic VTE within 90 days or asymptomatic deep venous thrombosis screened by compression ultrasonography at enrollment and 3-week follow-up. The association between baseline D-dimer levels and subsequent VTE events, adjusted for age, sex, ethnicity, body mass index, co-morbidities, and acute disease status, was assessed using multivariate Cox proportional hazard models.

Results: 49.1% (n = 225) of patients had elevated baseline D-dimer levels, and of these patients, 14.2% (n = 32) developed VTE during the 90-day follow-up. In contrast, only 5.6% (n = 13) of patients with normal D-dimer levels developed VTE. Multivariate analysis showed that patients with elevated D-dimer levels had a 3.2-fold increased risk of developing VTE (95% confidence interval, 1.5-6.5; P = 0.002) in comparison with patients with normal levels.

Conclusions: In elderly patients who were hospitalized for acute medical illness, elevated D-dimer levels are associated with subsequent VTE events. Our data suggest that measurement of D-dimer, a widely-performed objective test, may help clinicians address high-risk individuals for VTE.

语种: 英语
项目资助者: Pfizer ; GlaxoSmithKline
WOS记录号: WOS:000291783700006
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/67258
Appears in Collections:北京大学第一临床医学院_期刊论文

Files in This Item:

There are no files associated with this item.


作者单位: 1.Chinese Peoples Liberat Army Gen Hosp, Geriatr Cardiovasc Dept, Beijing 100853, Peoples R China
2.Peking Univ, Hosp 1, Dept Biomed Informat & Stat, Beijing 100871, Peoples R China
3.Guangzhou Inst Resp Dis, Dept Resp Med, Guangzhou, Guangdong, Peoples R China

Recommended Citation:
Fan, Jin,Li, Xiaoying,Cheng, Youqin,et al. Measurement of D-dimer as aid in risk evaluation of VTE in elderly patients hospitalized for acute illness: A prospective, multicenter study in China[J]. CLINICAL AND INVESTIGATIVE MEDICINE,2011,34(2):E96-E104.
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Fan, Jin]'s Articles
[Li, Xiaoying]'s Articles
[Cheng, Youqin]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Fan, Jin]‘s Articles
[Li, Xiaoying]‘s Articles
[Cheng, Youqin]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2017  北京大学医学部 - Feedback
Powered by CSpace