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学科主题: 临床医学
题名:
Measurement of D-dimer as aid in risk evaluation of VTE in elderly patients hospitalized for acute illness: A prospective, multicenter study in China
作者: Fan, Jin1; Li, Xiaoying1; Cheng, Youqin1; Yao, Chen2; Zhong, Nanshan3; In Estigators Grp
刊名: CLINICAL AND INVESTIGATIVE MEDICINE
发表日期: 2011
卷: 34, 期:2, 页:E96-E104
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Medicine, Research & Experimental
研究领域[WOS]: Research & Experimental Medicine
关键词[WOS]: DEEP-VEIN THROMBOSIS ; PREDICT VENOUS THROMBOEMBOLISM ; ILL MEDICAL PATIENTS ; PULMONARY-EMBOLISM ; ANTICOAGULATION ; THROMBOPHILIA ; PREVENTION ; PLACEBO
英文摘要:

Purpose: Advanced age and hospitalization are associated with increasing risk of venous thromboembolic (VTE) events. The aim of this study was to investigate whether elevated D-dimer levels could predict VTE events in elderly patients hospitalized for acute illness.

Methods: 458 consecutive patients (65% men; mean age, 77 +/- 7 years) who were older than 60 years, immobilized for >= 3 days, and hospitalized for heart failure, respiratory failure, acute ischemic stroke, or acute infectious disease without pharmacological prophylaxis or recent major surgery, were enrolled. Elevated D-dimer levels were defined as > 500 ng/ml. VTE events included symptomatic VTE within 90 days or asymptomatic deep venous thrombosis screened by compression ultrasonography at enrollment and 3-week follow-up. The association between baseline D-dimer levels and subsequent VTE events, adjusted for age, sex, ethnicity, body mass index, co-morbidities, and acute disease status, was assessed using multivariate Cox proportional hazard models.

Results: 49.1% (n = 225) of patients had elevated baseline D-dimer levels, and of these patients, 14.2% (n = 32) developed VTE during the 90-day follow-up. In contrast, only 5.6% (n = 13) of patients with normal D-dimer levels developed VTE. Multivariate analysis showed that patients with elevated D-dimer levels had a 3.2-fold increased risk of developing VTE (95% confidence interval, 1.5-6.5; P = 0.002) in comparison with patients with normal levels.

Conclusions: In elderly patients who were hospitalized for acute medical illness, elevated D-dimer levels are associated with subsequent VTE events. Our data suggest that measurement of D-dimer, a widely-performed objective test, may help clinicians address high-risk individuals for VTE.

语种: 英语
项目资助者: Pfizer ; GlaxoSmithKline
WOS记录号: WOS:000291783700006
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/67258
Appears in Collections:北京大学第一临床医学院_期刊论文

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作者单位: 1.Chinese Peoples Liberat Army Gen Hosp, Geriatr Cardiovasc Dept, Beijing 100853, Peoples R China
2.Peking Univ, Hosp 1, Dept Biomed Informat & Stat, Beijing 100871, Peoples R China
3.Guangzhou Inst Resp Dis, Dept Resp Med, Guangzhou, Guangdong, Peoples R China

Recommended Citation:
Fan, Jin,Li, Xiaoying,Cheng, Youqin,et al. Measurement of D-dimer as aid in risk evaluation of VTE in elderly patients hospitalized for acute illness: A prospective, multicenter study in China[J]. CLINICAL AND INVESTIGATIVE MEDICINE,2011,34(2):E96-E104.
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