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学科主题: 临床医学
题名:
Plasma level of lipopolysaccharide-binding protein is indicative of acute graft-versus-host disease following allogeneic hematopoietic stem cell transplantation
作者: Ye, Haige1,2; Lv, Meng1; Zhao, Xiaosu1; Zhao, Xiangyu1; Huang, Xiaojun1
关键词: Lipopolysaccharide-binding protein ; Hematopoietic stem cell transplantation ; Acute graft-versus-host disease
刊名: INTERNATIONAL JOURNAL OF HEMATOLOGY
发表日期: 2012-06-01
DOI: 10.1007/s12185-012-1076-z
卷: 95, 期:6, 页:680-688
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Hematology
研究领域[WOS]: Hematology
关键词[WOS]: BONE-MARROW-TRANSPLANTATION ; INNATE IMMUNE-SYSTEM ; SERUM-LEVELS ; SEVERITY ; SEPSIS
英文摘要:

Acute graft-versus-host disease (aGVHD) is the major cause of non-relapse mortality following allogeneic hematopoietic stem cell transplantation. To date, there are no consensus specific plasma biomarkers for aGVHD. We recently identified several candidates differentially expressed in aGVHD patients. Here, we have validated one such candidate: lipopolysaccharide-binding protein (LBP). We detected plasma LBP level by ELISA in 73 patients and performed correlation analysis with the progression and severity of aGVHD. We found that plasma LBP level increased during the period of aGVHD and decreased markedly as aGVHD was resolved. LBP level in patients with moderate aGVHD (25-50 % skin rash area of grade 1 and grade 2) was higher than in patients with no, little (skin rash area < 25 % of grade 1), or severe aGVHD (grade 3-4). Higher LBP level indicated higher probability of aGVHD. Multivariate analysis showed that LBP level above 15000 ng/ml was significantly associated with an increased risk of aGVHD (HR 2.43; 95 % CI 1.29-4.58; P = 0.006). If LBP level exceeded 15000 ng/ml at d7 and d14 after HSCT, the subsequent probability of aGVHD increased markedly, especially at the time point of d14. There was no correlation between LBP level and the site of aGVHD. In conclusion, our study demonstrated that an elevated LBP level of > 15000 ng/ml may serve as a biomarker for the prediction and monitoring of aGVHD.

语种: 英语
所属项目编号: 2011AA020105 ; 30971292
项目资助者: National High Technology Research and Development Program of China (Program 863) ; National Natural Science Foundation of China
WOS记录号: WOS:000305413700015
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/67259
Appears in Collections:北京大学第二临床医学院_血液科_期刊论文

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作者单位: 1.Peking Univ, Beijing Key Lab Hematopoiet Stem Cell Transplanta, Inst Hematol, Peoples Hosp, Beijing 100044, Peoples R China
2.Wenzhou Med Coll, Affiliated Hosp 1, Dept Hematol, Wenzhou, Zhejiang, Peoples R China

Recommended Citation:
Ye, Haige,Lv, Meng,Zhao, Xiaosu,et al. Plasma level of lipopolysaccharide-binding protein is indicative of acute graft-versus-host disease following allogeneic hematopoietic stem cell transplantation[J]. INTERNATIONAL JOURNAL OF HEMATOLOGY,2012,95(6):680-688.
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