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学科主题: 公共卫生
题名:
Therapeutic Effects of Marine Collagen Peptides on Chinese Patients With Type 2 Diabetes Mellitus and Primary Hypertension
作者: Zhu, Cui-Feng1,2; Li, Guan-Zhi1; Peng, Hong-Bin1; Zhang, Fan3; Chen, Yun4; Li, Yong1
关键词: Marine collagen peptides ; Type 2 diabetes mellitus ; Hypertension ; Insulin sensitivity ; Adipokine
刊名: AMERICAN JOURNAL OF THE MEDICAL SCIENCES
发表日期: 2010-11-01
DOI: 10.1097/MAJ.0b013e3181edfcf2
卷: 340, 期:5, 页:360-366
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Medicine, General & Internal
研究领域[WOS]: General & Internal Medicine
关键词[WOS]: INSULIN-RESISTANCE ; PROTEIN ; OBESITY ; ADIPONECTIN ; MODULATION ; DISEASE ; HUMANS ; GAMMA
英文摘要:

Introduction: Marine collagen peptides (MCPs) from deep sea fish are shown to ameliorate hyperlipidemia in animal models. The study aimed at examining the effects of MCPs on glucose and lipid metabolism in Chinese patients with type 2 diabetes mellitus (T2DM) and primary hypertension. Methods: One hundred patients with T2DM and primary hypertension and 50 healthy subjects (normal controls) were recruited for a randomized double blind study. The patients were randomized into MCPs treatment or patient control groups (n = 50 per group). Both patient controls and normal controls were given carboxymethylcellulose twice daily whereas the MCPs treatment group was given MCPs twice daily for 3 months. Blood pressure, glucose and lipid metabolism, serum high-sensitivity C-reactive protein, cytochrome P450, nitric oxide, bradykinin, prostacyclin, creatinine, uric acid and adipokines were measured at baseline, 1.5 and 3 months after treatment. All patients received regular medicines for control of hyperglycemia and hypertension. Results: Compared with patient controls, significantly reduced levels of fasting blood glucose, HbA1c, diastolic blood pressure, mean arterial pressure and creatinine but increased levels of Insulin Sensitivity Index and Insulin Secretion Index were observed in patients receiving MCPs treatment. Furthermore, significantly reduced levels of serum triglycerides, total cholesterol, low-density lipoprotein, free fatty acids, cytochrome P450, nitric oxide and prostacyclin but increased levels of high-density lipoprotein, bradykinin and adiponectin were detected in patients taking MCPs. Conclusions: MCPs supplement may benefit glucose and lipid metabolism, insulin sensitivity, renal function and hypertension management in Chinese patients with T2DM and hypertension.

语种: 英语
所属项目编号: 2006BAD27B01 ; 2006BAD27B08 ; DIC-200710 ; 200802002
项目资助者: National Key Technology RD Program ; CDC Dalone Foundation of Dietary Nutrition ; Shenzhen Bureau of Science Technology and Information
WOS记录号: WOS:000283802300004
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/67263
Appears in Collections:北京大学公共卫生学院_期刊论文

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作者单位: 1.Peking Univ, Dept Nutr & Food Hyg, Sch Publ Hlth, Beijing 100083, Peoples R China
2.Peking Univ, Shenzhen Hosp, Dept Nutr, Shenzhen, Peoples R China
3.Peking Univ, Shenzhen Hosp, Dept Endocrinol, Shenzhen, Peoples R China
4.Peking Univ, Shenzhen Hosp, Ultrasound Div, Shenzhen, Peoples R China

Recommended Citation:
Zhu, Cui-Feng,Li, Guan-Zhi,Peng, Hong-Bin,et al. Therapeutic Effects of Marine Collagen Peptides on Chinese Patients With Type 2 Diabetes Mellitus and Primary Hypertension[J]. AMERICAN JOURNAL OF THE MEDICAL SCIENCES,2010,340(5):360-366.
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