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Therapeutic Effects of Marine Collagen Peptides on Chinese Patients With Type 2 Diabetes Mellitus and Primary Hypertension
Zhu, Cui-Feng1,2; Li, Guan-Zhi1; Peng, Hong-Bin1; Zhang, Fan3; Chen, Yun4; Li, Yong1
关键词Marine collagen peptides Type 2 diabetes mellitus Hypertension Insulin sensitivity Adipokine
刊名AMERICAN JOURNAL OF THE MEDICAL SCIENCES
2010-11-01
DOI10.1097/MAJ.0b013e3181edfcf2
340期:5页:360-366
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Medicine, General & Internal
研究领域[WOS]General & Internal Medicine
关键词[WOS]INSULIN-RESISTANCE ; PROTEIN ; OBESITY ; ADIPONECTIN ; MODULATION ; DISEASE ; HUMANS ; GAMMA
英文摘要

Introduction: Marine collagen peptides (MCPs) from deep sea fish are shown to ameliorate hyperlipidemia in animal models. The study aimed at examining the effects of MCPs on glucose and lipid metabolism in Chinese patients with type 2 diabetes mellitus (T2DM) and primary hypertension. Methods: One hundred patients with T2DM and primary hypertension and 50 healthy subjects (normal controls) were recruited for a randomized double blind study. The patients were randomized into MCPs treatment or patient control groups (n = 50 per group). Both patient controls and normal controls were given carboxymethylcellulose twice daily whereas the MCPs treatment group was given MCPs twice daily for 3 months. Blood pressure, glucose and lipid metabolism, serum high-sensitivity C-reactive protein, cytochrome P450, nitric oxide, bradykinin, prostacyclin, creatinine, uric acid and adipokines were measured at baseline, 1.5 and 3 months after treatment. All patients received regular medicines for control of hyperglycemia and hypertension. Results: Compared with patient controls, significantly reduced levels of fasting blood glucose, HbA1c, diastolic blood pressure, mean arterial pressure and creatinine but increased levels of Insulin Sensitivity Index and Insulin Secretion Index were observed in patients receiving MCPs treatment. Furthermore, significantly reduced levels of serum triglycerides, total cholesterol, low-density lipoprotein, free fatty acids, cytochrome P450, nitric oxide and prostacyclin but increased levels of high-density lipoprotein, bradykinin and adiponectin were detected in patients taking MCPs. Conclusions: MCPs supplement may benefit glucose and lipid metabolism, insulin sensitivity, renal function and hypertension management in Chinese patients with T2DM and hypertension.

语种英语
WOS记录号WOS:000283802300004
引用统计
被引频次:12[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/67263
专题北京大学公共卫生学院
作者单位1.Peking Univ, Dept Nutr & Food Hyg, Sch Publ Hlth, Beijing 100083, Peoples R China
2.Peking Univ, Shenzhen Hosp, Dept Nutr, Shenzhen, Peoples R China
3.Peking Univ, Shenzhen Hosp, Dept Endocrinol, Shenzhen, Peoples R China
4.Peking Univ, Shenzhen Hosp, Ultrasound Div, Shenzhen, Peoples R China
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GB/T 7714
Zhu, Cui-Feng,Li, Guan-Zhi,Peng, Hong-Bin,et al. Therapeutic Effects of Marine Collagen Peptides on Chinese Patients With Type 2 Diabetes Mellitus and Primary Hypertension[J]. AMERICAN JOURNAL OF THE MEDICAL SCIENCES,2010,340(5):360-366.
APA Zhu, Cui-Feng,Li, Guan-Zhi,Peng, Hong-Bin,Zhang, Fan,Chen, Yun,&Li, Yong.(2010).Therapeutic Effects of Marine Collagen Peptides on Chinese Patients With Type 2 Diabetes Mellitus and Primary Hypertension.AMERICAN JOURNAL OF THE MEDICAL SCIENCES,340(5),360-366.
MLA Zhu, Cui-Feng,et al."Therapeutic Effects of Marine Collagen Peptides on Chinese Patients With Type 2 Diabetes Mellitus and Primary Hypertension".AMERICAN JOURNAL OF THE MEDICAL SCIENCES 340.5(2010):360-366.
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