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学科主题基础医学
Differential protein expression in heart in UT-B null mice with cardiac conduction defects
Yu, Hao1; Meng, Yan1; Wang, Li-Shun2; Jin, Xian2; Gao, Li-Fang1; Zhou, Lei1; Ji, Kun1; Li, Yang1; Zhao, Li-Juan1; Chen, Guo-Qiang2; Zhao, Xue-Jian1; Yang, Baoxue3
关键词Cardiac conduction block Differential protein expression Urea transporter UT-B
刊名PROTEOMICS
2009-02-01
DOI10.1002/pmic.200701079
9期:3页:504-511
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biochemical Research Methods ; Biochemistry & Molecular Biology
研究领域[WOS]Biochemistry & Molecular Biology
关键词[WOS]URINARY CONCENTRATING ABILITY ; NATRIURETIC-PEPTIDE ; UREA ; MUTATION ; CARDIOMYOPATHY ; DISEASE ; CELLS ; ERYTHROCYTES ; HYPERTROPHY ; TRANSPORT
英文摘要

Cardiac conduction defects were found in transgenic mice deficient in urea transporter UT-B. To investigate the molecular mechanisms of the conduction defects caused by UT-B deletion, we studied the protein expression profiles of heart tissue (comprising most conduction system) in wild-type versus UT-B null mice at different ages. By two-dimensional electrophoresis-based comparative analysis, we found that more than dozen proteins were modulated (> two-fold) in the myocardium of UT-B null mice. Out of these modulated proteins, troponin T (TNNT2) presented significant changes in UT-B null mice at early stage prior to the development of P-R interval elongation, while the change of atrial natriuretic peptide (ANP) occurred only at late stage in UT-B null mice that had the AV block. These data indicate that UT-B deletion caused the dynamic expression regulation of TNNT2 and ANP, and these proteins may provide new clues to investigate the molecular events involved in cardiac conduction.

语种英语
WOS记录号WOS:000263578600003
项目编号30370572 ; 30870921 ; 2006AA02Z105
资助机构National Natural Science Foundation of China ; Ministry of Science and Technology ; 985 Projects of Ministry of Education of China
引用统计
被引频次:8[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/67265
专题北京大学基础医学院_药理学系
北京大学基础医学院
作者单位1.Jilin Univ, Dept Pathophysiol, Res Ctr Prostate Dis, Sch Basic Med, Changchun 130023, Peoples R China
2.Shanghai Jiao Tong Univ, Dept Pathophysiol, Ruijin Hosp, Sch Med, Shanghai 200030, Peoples R China
3.Peking Univ, Dept Pharmacol, Sch Basic Med Sci, Beijing 100871, Peoples R China
推荐引用方式
GB/T 7714
Yu, Hao,Meng, Yan,Wang, Li-Shun,et al. Differential protein expression in heart in UT-B null mice with cardiac conduction defects[J]. PROTEOMICS,2009,9(3):504-511.
APA Yu, Hao.,Meng, Yan.,Wang, Li-Shun.,Jin, Xian.,Gao, Li-Fang.,...&Yang, Baoxue.(2009).Differential protein expression in heart in UT-B null mice with cardiac conduction defects.PROTEOMICS,9(3),504-511.
MLA Yu, Hao,et al."Differential protein expression in heart in UT-B null mice with cardiac conduction defects".PROTEOMICS 9.3(2009):504-511.
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