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Chemical constituents of ambient particulate air pollution and biomarkers of inflammation, coagulation and homocysteine in healthy adults: A prospective panel study
Wu, Shaowei1; Deng, Furong1; Wei, Hongying1; Huang, Jing1; Wang, Hongyi2; Shima, Masayuki3; Wang, Xin1; Qin, Yu1; Zheng, Chanjuan1; Hao, Yu1; Guo, Xinbiao1
关键词Air pollution Chemical constituent Coagulation Inflammation Panel study Particulate matter
刊名PARTICLE AND FIBRE TOXICOLOGY
2012-12-12
DOI10.1186/1743-8977-9-49
9
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Toxicology
研究领域[WOS]Toxicology
关键词[WOS]DIESEL-EXHAUST INHALATION ; CORONARY-HEART-DISEASE ; NECROSIS-FACTOR-ALPHA ; CARDIOVASCULAR-DISEASE ; HOSPITAL ADMISSIONS ; ATMOSPHERIC AEROSOL ; VASCULAR FUNCTION ; RATE-VARIABILITY ; BLOOD-PRESSURE ; OLYMPIC GAMES
英文摘要

Background: Ambient air pollution has been associated with activation of systemic inflammation and hypercoagulability and increased plasma homocysteine, but the chemical constituents behind the association are not well understood. We examined the relations of various chemical constituents of fine particles (PM2.5) and biomarkers of inflammation, coagulation and homocysteine in the context of traffic-related air pollution.

Methods: A panel of 40 healthy college students underwent biweekly blood collection for 12 times before and after their relocation from a suburban campus to an urban campus with changing air pollution contents in Beijing. Blood samples were measured for circulatory biomarkers of high-sensitivity C reactive protein (hs-CRP), tumor necrosis factor alpha (TNF-alpha), fibrinogen, plasminogen activator inhibitor type 1 (PAI-1), tissue-type plasminogen activator (t-PA), von Willebrand factor (vWF), soluble platelet selectin (sP-selectin), and total homocysteine (tHcy). Various air pollutants were measured in a central air-monitoring station in each campus and 32 PM2.5 chemical constituents were determined in the laboratory. We used three different mixed-effects models (single-constituent model, constituent-PM2.5 joint model and constituent residual model) controlling for potential confounders to estimate the effects of PM2.5 chemical constituents on circulatory biomarkers.

Results: We found consistent positive associations between the following biomarkers and PM2.5 chemical constituents across different models: TNF-alpha with secondary organic carbon, chloride, zinc, molybdenum and stannum; fibrinogen with magnesium, iron, titanium, cobalt and cadmium; PAI-1 with titanium, cobalt and manganese; t-PA with cadmium and selenium; vWF with aluminum. We also found consistent inverse associations of vWF with nitrate, chloride and sodium, and sP-selectin with manganese. Two positive associations of zinc with TNF-alpha and of cobalt with fibrinogen, and two inverse associations of nitrate with vWF, and of manganese with sP-selectin, were independent of the other constituents in two-constituent models using constituent residual data. We only found weak air pollution effects on hs-CRP and tHcy.

Conclusions: Our results provide clues for the potential roles that PM2.5 chemical constituents may play in the biological mechanisms through which air pollution may influence the cardiovascular system.

语种英语
WOS记录号WOS:000316081500001
项目编号81072267 ; 2006BAI19B06
资助机构National Natural Science Foundation of China ; National Key Technologies R&amp ; D Program of China ; Academic Award for Excellent Doctoral Candidates of the Ministry of Education of the People&prime ; s Republic of China
引用统计
被引频次:42[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/67266
专题北京大学公共卫生学院
北京大学公共卫生学院_劳动卫生与环境卫生学系
北京大学公共卫生学院_公共卫生学院
作者单位1.Peking Univ, Dept Occupat & Environm Hlth Sci, Sch Publ Hlth, Beijing 100871, Peoples R China
2.Peking Univ, Peoples Hosp, Dept Cardiol, Beijing 100871, Peoples R China
3.Hyogo Coll Med, Dept Publ Hlth, Nishinomiya, Hyogo, Japan
推荐引用方式
GB/T 7714
Wu, Shaowei,Deng, Furong,Wei, Hongying,et al. Chemical constituents of ambient particulate air pollution and biomarkers of inflammation, coagulation and homocysteine in healthy adults: A prospective panel study[J]. PARTICLE AND FIBRE TOXICOLOGY,2012,9.
APA Wu, Shaowei.,Deng, Furong.,Wei, Hongying.,Huang, Jing.,Wang, Hongyi.,...&Guo, Xinbiao.(2012).Chemical constituents of ambient particulate air pollution and biomarkers of inflammation, coagulation and homocysteine in healthy adults: A prospective panel study.PARTICLE AND FIBRE TOXICOLOGY,9.
MLA Wu, Shaowei,et al."Chemical constituents of ambient particulate air pollution and biomarkers of inflammation, coagulation and homocysteine in healthy adults: A prospective panel study".PARTICLE AND FIBRE TOXICOLOGY 9(2012).
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