|Dark-light Change of Iris Parameters and Related Factors Among American Caucasians, American Chinese, and Mainland Chinese|
|Wang, Dandan1,2; He, Mingguang1; Wu, Lingling3; Kao, Andrew2; Pekmezci, Melike2; Singh, Kuldev4; Lin, Shan2|
|关键词||Dark-light change Iris Pupil Ethnic difference Anterior segment optical coherence tomography|
|刊名||CURRENT EYE RESEARCH|
|WOS标题词||Science & Technology|
|关键词[WOS]||ANGLE-CLOSURE GLAUCOMA ; OPTICAL COHERENCE TOMOGRAPHY ; SINGAPOREANS ; ASSOCIATION ; BIOMETRY|
Purpose: To assess the distribution of dark-light changes in iris features and associated factors amongst American Caucasians, American Chinese and mainland Chinese aged 40 years and over.
Methods: Four gender-and age-matched cohorts: Caucasians, American Chinese, Southern Chinese and Northern Chinese comprised the study population. Anterior segment optical coherence tomography (ASOCT) images were acquired under dark and light conditions. Customized software was used to calculate iris thickness at 750 mu m from the scleral spur (IT750), iris curvature (ICurv), iris area (IArea), and pupil diameter (PD) from ASOCT images.
Results: Data from 121, 124, 121 and 120 subjects were available for American Caucasian, American Chinese, Southern and Northern Chinese subjects respectively. Caucasians had significantly less dark-light change (Delta) of IT750 and greater Delta PD than Chinese. When using multiple linear regression analyses, the inter-ethnic difference for Delta IT750 was independent of age, gender, refractive error, anterior chamber width and axial length. After controlling for Delta PD, Delta ICurv was found to be inversely associated with age (beta = -0.001, P = 0.001). Independent predictors of greater Delta PD included younger age (beta = -0.02, P = 0.001), Caucasian ethnicity (beta = -0.022, P = 0.009) and wider anterior chamber (beta = 0.18, P = 0.03).
Conclusions: Compared with Caucasians, Chinese irides show greater thickening with light to dark adaptation despite the lesser change of PD in Chinese. The change of iris area per unit change of pupil diameter from dark to light did not differ between ethnicities. These dynamic characteristics intrinsic to Chinese irides may partially account for the substantially increased risk for angle closure among this ethnic group.
|资助机构||George and Rosalie Hearst Foreign Fellowship ; That Man May See, Inc. ; Research to Prevent Blindness ; NEI|
|作者单位||1.Sun Yat Sen Univ, Zhongshan Ophthalm Ctr, State Key Lab Ophthalmol, Guangzhou 510275, Guangdong, Peoples R China|
2.Univ Calif San Francisco, San Francisco, CA 94143 USA
3.Peking Univ, Ctr Eye, Hosp 3, Beijing 100871, Peoples R China
4.Stanford Univ, Palo Alto, CA 94304 USA
|Wang, Dandan,He, Mingguang,Wu, Lingling,et al. Dark-light Change of Iris Parameters and Related Factors Among American Caucasians, American Chinese, and Mainland Chinese[J]. CURRENT EYE RESEARCH,2012,37(7):599-605.|
|APA||Wang, Dandan.,He, Mingguang.,Wu, Lingling.,Kao, Andrew.,Pekmezci, Melike.,...&Lin, Shan.(2012).Dark-light Change of Iris Parameters and Related Factors Among American Caucasians, American Chinese, and Mainland Chinese.CURRENT EYE RESEARCH,37(7),599-605.|
|MLA||Wang, Dandan,et al."Dark-light Change of Iris Parameters and Related Factors Among American Caucasians, American Chinese, and Mainland Chinese".CURRENT EYE RESEARCH 37.7(2012):599-605.|