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学科主题: 基础医学
题名:
CEREBRAL BLOOD FLOW-BASED EVIDENCE FOR MECHANISMS OF LOW- VERSUS HIGH-FREQUENCY TRANSCUTANEOUS ELECTRIC ACUPOINT STIMULATION ANALGESIA: A PERFUSION FMRI STUDY IN HUMANS
作者: Jiang, Y.1,2,3,4; Liu, J.5; Liu, J.6; Han, J.1,2,3,4; Wang, X.5; Cui, C.1,2,3,4
关键词: frequency ; acupuncture analgesia ; transcutaneous electric acupoint stimulation ; cerebral blood flow
刊名: NEUROSCIENCE
发表日期: 2014-05-30
DOI: 10.1016/j.neuroscience.2014.03.019
卷: 268, 期:30, 页:180-193
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Neurosciences
研究领域[WOS]: Neurosciences & Neurology
关键词[WOS]: AFFECTIVE DIMENSION ; DEFAULT-MODE ; HUMAN BRAIN ; PAIN ; ACUPUNCTURE ; ELECTROACUPUNCTURE ; NETWORKS ; AWARENESS ; BOLD
英文摘要:

Brain activities in response to acupuncture have been investigated in multiple studies; however, the neuromechanisms of low-and high-frequency transcutaneous electric acupoint stimulation (TEAS) analgesia are unclear. This work aimed to investigate how brain activity and the analgesic effect changed across 30-min low- versus high-frequency TEAS. Forty-six subjects received a 30-min 2, 100-Hz TEAS or mock TEAS (MTEAS) treatment on both behavior test and functional magnetic resonance imaging (fMRI) scan days. On the behavior test day, the pain thresholds and pain-related negative emotional feeling ratings were tested five times -at 4.5 min before treatment, at 10, 20, and 30 min during treatment and 4.5 min after the treatment. On the fMRI scan day, to match the time-points in the behavioral testing session, the cerebral blood flow (CBF) signals were collected and incorporated with five independent runs before, during and after the treatment, each lasting 4.5 min. The analgesic effect was observed in both the TEAS groups; the analgesic affect was not found in the MTEAS group. The effect started at 20 min during the treatment and was maintained until the after-treatment states. In both TEAS groups, the regional CBF revealed a trend of early activation with later inhibition; also, a positive correlation between analgesia and the regional CBF change was observed in the anterior insula in the early stage, whereas a negative relationship was found in the parahippocampal gyrus in the later stage. The TEAS analgesia was specifically associated with the default mode network and other cortical regions in the 2-Hz TEAS group, ventral striatum and dorsal anterior cingulate cortex in the 100-Hz TEAS group, respectively. These findings suggest that the mechanisms of lowand high-frequency TEAS analgesia are distinct and partially overlapped, and they verify the treatment time as a notable factor for acupuncture studies. (C) 2014 IBRO. Published by Elsevier Ltd. All rights reserved.

语种: 英语
所属项目编号: 2013CB531905 ; 2009CB522003 ; 2204003
项目资助者: National Basic Research Program of China ; Project of Innovation Research Team of China Academy of Chinese Medical Sciences
WOS记录号: WOS:000335501900017
Citation statistics:
内容类型: 期刊论文
版本: 出版稿
URI标识: http://ir.bjmu.edu.cn/handle/400002259/67269
Appears in Collections:基础医学院_神经生物学系_期刊论文

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CEREBRAL BLOOD FLOW-BASED EVIDENCE FOR MECHANISMS OF LOW- VERSUS HIGH-FREQUENCY TRANSCUTANEOUS ELECTRIC ACUPOINT STIMULATION ANALGESIA A PERFUSION FMRI STUDY IN HUMANS.pdf(2790KB)期刊论文出版稿限制开放 联系获取全文

作者单位: 1.Peking Univ, Neurosci Res Inst, Beijing 100191, Peoples R China
2.Peking Univ, Dept Neurobiol, Sch Basic Med Sci, Beijing 100191, Peoples R China
3.Minist Educ, Key Lab Neurosci, Beijing, Peoples R China
4.Minist Publ Hlth, Beijing, Peoples R China
5.Peking Univ, Hosp 1, Dept Radiol, Beijing 100191, Peoples R China
6.China Acad Chinese Med Sci, Inst Acumoxibust, Beijing, Peoples R China

Recommended Citation:
Jiang, Y.,Liu, J.,Liu, J.,et al. CEREBRAL BLOOD FLOW-BASED EVIDENCE FOR MECHANISMS OF LOW- VERSUS HIGH-FREQUENCY TRANSCUTANEOUS ELECTRIC ACUPOINT STIMULATION ANALGESIA: A PERFUSION FMRI STUDY IN HUMANS[J]. NEUROSCIENCE,2014,268(30):180-193.
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