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学科主题基础医学
CEREBRAL BLOOD FLOW-BASED EVIDENCE FOR MECHANISMS OF LOW- VERSUS HIGH-FREQUENCY TRANSCUTANEOUS ELECTRIC ACUPOINT STIMULATION ANALGESIA: A PERFUSION FMRI STUDY IN HUMANS
Jiang, Y.1,2,3,4; Liu, J.5; Liu, J.6; Han, J.1,2,3,4; Wang, X.5; Cui, C.1,2,3,4
关键词frequency acupuncture analgesia transcutaneous electric acupoint stimulation cerebral blood flow
刊名NEUROSCIENCE
2014-05-30
DOI10.1016/j.neuroscience.2014.03.019
268期:30页:180-193
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Neurosciences
研究领域[WOS]Neurosciences & Neurology
关键词[WOS]AFFECTIVE DIMENSION ; DEFAULT-MODE ; HUMAN BRAIN ; PAIN ; ACUPUNCTURE ; ELECTROACUPUNCTURE ; NETWORKS ; AWARENESS ; BOLD
英文摘要

Brain activities in response to acupuncture have been investigated in multiple studies; however, the neuromechanisms of low-and high-frequency transcutaneous electric acupoint stimulation (TEAS) analgesia are unclear. This work aimed to investigate how brain activity and the analgesic effect changed across 30-min low- versus high-frequency TEAS. Forty-six subjects received a 30-min 2, 100-Hz TEAS or mock TEAS (MTEAS) treatment on both behavior test and functional magnetic resonance imaging (fMRI) scan days. On the behavior test day, the pain thresholds and pain-related negative emotional feeling ratings were tested five times -at 4.5 min before treatment, at 10, 20, and 30 min during treatment and 4.5 min after the treatment. On the fMRI scan day, to match the time-points in the behavioral testing session, the cerebral blood flow (CBF) signals were collected and incorporated with five independent runs before, during and after the treatment, each lasting 4.5 min. The analgesic effect was observed in both the TEAS groups; the analgesic affect was not found in the MTEAS group. The effect started at 20 min during the treatment and was maintained until the after-treatment states. In both TEAS groups, the regional CBF revealed a trend of early activation with later inhibition; also, a positive correlation between analgesia and the regional CBF change was observed in the anterior insula in the early stage, whereas a negative relationship was found in the parahippocampal gyrus in the later stage. The TEAS analgesia was specifically associated with the default mode network and other cortical regions in the 2-Hz TEAS group, ventral striatum and dorsal anterior cingulate cortex in the 100-Hz TEAS group, respectively. These findings suggest that the mechanisms of lowand high-frequency TEAS analgesia are distinct and partially overlapped, and they verify the treatment time as a notable factor for acupuncture studies. (C) 2014 IBRO. Published by Elsevier Ltd. All rights reserved.

语种英语
WOS记录号WOS:000335501900017
项目编号2013CB531905 ; 2009CB522003 ; 2204003
资助机构National Basic Research Program of China ; Project of Innovation Research Team of China Academy of Chinese Medical Sciences
引用统计
被引频次:7[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
版本出版稿
条目标识符http://ir.bjmu.edu.cn/handle/400002259/67269
专题北京大学基础医学院_神经生物学系
北京大学口腔医学院_牙体牙髓科
作者单位1.Peking Univ, Neurosci Res Inst, Beijing 100191, Peoples R China
2.Peking Univ, Dept Neurobiol, Sch Basic Med Sci, Beijing 100191, Peoples R China
3.Minist Educ, Key Lab Neurosci, Beijing, Peoples R China
4.Minist Publ Hlth, Beijing, Peoples R China
5.Peking Univ, Hosp 1, Dept Radiol, Beijing 100191, Peoples R China
6.China Acad Chinese Med Sci, Inst Acumoxibust, Beijing, Peoples R China
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GB/T 7714
Jiang, Y.,Liu, J.,Liu, J.,et al. CEREBRAL BLOOD FLOW-BASED EVIDENCE FOR MECHANISMS OF LOW- VERSUS HIGH-FREQUENCY TRANSCUTANEOUS ELECTRIC ACUPOINT STIMULATION ANALGESIA: A PERFUSION FMRI STUDY IN HUMANS[J]. NEUROSCIENCE,2014,268(30):180-193.
APA Jiang, Y.,Liu, J.,Liu, J.,Han, J.,Wang, X.,&Cui, C..(2014).CEREBRAL BLOOD FLOW-BASED EVIDENCE FOR MECHANISMS OF LOW- VERSUS HIGH-FREQUENCY TRANSCUTANEOUS ELECTRIC ACUPOINT STIMULATION ANALGESIA: A PERFUSION FMRI STUDY IN HUMANS.NEUROSCIENCE,268(30),180-193.
MLA Jiang, Y.,et al."CEREBRAL BLOOD FLOW-BASED EVIDENCE FOR MECHANISMS OF LOW- VERSUS HIGH-FREQUENCY TRANSCUTANEOUS ELECTRIC ACUPOINT STIMULATION ANALGESIA: A PERFUSION FMRI STUDY IN HUMANS".NEUROSCIENCE 268.30(2014):180-193.
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