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Neuroanatomical Circuitry Associated with Exploratory Eye Movement in Schizophrenia: A Voxel-Based Morphometric Study
Qiu, Linlin1,2; Tian, Lin1,2; Pan, Chao1,2; Zhu, Risheng1,2; Liu, Qi1,2; Yan, Jun1,2; Zhao, Qiang3; Yuan, Huishu3; Han, Yonghua1,2; Yue, Weihua1,2; Yan, Hao1,2; Zhang, Dai1,2
刊名PLOS ONE
2011-10-03
DOI10.1371/journal.pone.0025805
6期:10
收录类别SCI ; SSCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Multidisciplinary Sciences
资助者National Basic Research Program of China ; National Natural Science Foundation of China ; Capital Foundation of Medical Developments ; International Science and Technology Cooperation Program of China ; National Basic Research Program of China ; National Natural Science Foundation of China ; Capital Foundation of Medical Developments ; International Science and Technology Cooperation Program of China
研究领域[WOS]Science & Technology - Other Topics
关键词[WOS]SPATIAL WORKING-MEMORY ; SMOOTH-PURSUIT ; VISUAL-OBJECT ; FUNCTIONAL NEUROANATOMY ; TRACKING DYSFUNCTION ; CORTICAL CONTROL ; BRAIN ; CORTEX ; RECOGNITION ; DEFICITS
英文摘要

Schizophrenic patients present abnormalities in a variety of eye movement tasks. Exploratory eye movement (EEM) dysfunction appears to be particularly specific to schizophrenia. However, the underlying mechanisms of EEM dysfunction in schizophrenia are not clearly understood. To assess the potential neuroanatomical substrates of EEM, we recorded EEM performance and conducted a voxel-based morphometric analysis of gray matter in 33 schizophrenic patients and 29 well matched healthy controls. In schizophrenic patients, decreased responsive search score (RSS) and widespread gray matter density (GMD) reductions were observed. Moreover, the RSS was positively correlated with GMD in distributed brain regions in schizophrenic patients. Furthermore, in schizophrenic patients, some brain regions with neuroanatomical deficits overlapped with some ones associated with RSS. These brain regions constituted an occipito-tempro-frontal circuitry involved in visual information processing and eye movement control, including the left calcarine cortex [ Brodmann area (BA) 17], the left cuneus (BA 18), the left superior occipital cortex (BA 18/19), the left superior frontal gyrus (BA 6), the left cerebellum, the right lingual cortex (BA 17/18), the right middle occipital cortex (BA19), the right inferior temporal cortex (BA 37), the right dorsolateral prefrontal cortex (BA 46) and bilateral precentral gyri (BA 6) extending to the frontal eye fields (FEF, BA 8). To our knowledge, we firstly reported empirical evidence that gray matter loss in the occipito-tempro-frontal neuroanatomical circuitry of visual processing system was associated with EEM performance in schizophrenia, which may be helpful for the future effort to reveal the underlying neural mechanisms for EEM disturbances in schizophrenia.

语种英语
所属项目编号2011CB707805 ; 2007CB512301 ; 81071088 ; 81000580 ; 2007-1001 ; 2010DFB30820
资助者National Basic Research Program of China ; National Natural Science Foundation of China ; Capital Foundation of Medical Developments ; International Science and Technology Cooperation Program of China ; National Basic Research Program of China ; National Natural Science Foundation of China ; Capital Foundation of Medical Developments ; International Science and Technology Cooperation Program of China
WOS记录号WOS:000295943000074
引用统计
被引频次:12[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/67271
专题北京大学精神卫生研究所
作者单位1.Peking Univ, Inst Mental Hlth, Beijing 100871, Peoples R China
2.Minist Hlth, Key Lab Mental Hlth, Beijing, Peoples R China
3.Peking Univ, Dept Radiol, Hosp 3, Beijing 100871, Peoples R China
推荐引用方式
GB/T 7714
Qiu, Linlin,Tian, Lin,Pan, Chao,et al. Neuroanatomical Circuitry Associated with Exploratory Eye Movement in Schizophrenia: A Voxel-Based Morphometric Study[J]. PLOS ONE,2011,6(10).
APA Qiu, Linlin.,Tian, Lin.,Pan, Chao.,Zhu, Risheng.,Liu, Qi.,...&Zhang, Dai.(2011).Neuroanatomical Circuitry Associated with Exploratory Eye Movement in Schizophrenia: A Voxel-Based Morphometric Study.PLOS ONE,6(10).
MLA Qiu, Linlin,et al."Neuroanatomical Circuitry Associated with Exploratory Eye Movement in Schizophrenia: A Voxel-Based Morphometric Study".PLOS ONE 6.10(2011).
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