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学科主题: 基础医学
题名:
Circulating Chemokine (C-X-C Motif) Receptor 5(+)CD4(+) T Cells Benefit Hepatitis B e Antigen Seroconversion Through IL-21 in Patients With Chronic Hepatitis B Virus Infection
作者: Li, Yongyin1,2; Ma, Shiwu1,2,3; Tang, Libo1,2; Li, Yun1,2; Wang, Wei4; Huang, Xuan1,2; Lai, Qintao1,2; Zhang, Mingxia1,2; Sun, Jian1,2; Li, Chris Kafai5; Abbott, William G. H.6; Naoumov, Nikolai V.7; Zhang, Yu4; Hou, Jinlin1,2
刊名: HEPATOLOGY
发表日期: 2013-10-01
DOI: 10.1002/hep.26489
卷: 58, 期:4, 页:1277-1286
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Gastroenterology & Hepatology
研究领域[WOS]: Gastroenterology & Hepatology
关键词[WOS]: HBEAG SEROCONVERSION ; ANTIVIRAL THERAPY ; IMMUNE-RESPONSES ; EXPRESSION
英文摘要:

Given the clinical significance of hepatitis B e antigen (HBeAg) seroconversion in chronic hepatitis B virus (HBV) infection, it is critical to elucidate the mechanisms regulating this process. In the present study, we found that the frequency of circulating chemokine (C-X-C motif) receptor 5 (CXCR5)(+)CD4(+) T cells was higher in patients who had achieved HBeAg seroconversion in both cross-sectional (P<0.001) and longitudinal (P = 0.009) studies. These cells were able to produce a significantly higher level of intracellular interleukin 21 (IL-21) after stimulation with HBV peptides in patients with telbivudine-induced HBeAg seroconversion (P=0.007). Furthermore, sorted CXCR5(+)CD4(+) T cells from HBeAg seroconverters boosted a higher frequency of antibody against hepatitis B e antigen (anti-HBe)-secreting B cells in coculture assay (P=0.011). Of note, the increase in frequency of anti-HBe-secreting B cells was abrogated by soluble recombinant IL-21 receptor-Fc chimera (P=0.027), whereas exogenous recombinant IL-21 enhanced this effect (P=0.043). Additionally, circulating CXCR5(+)CD4(+) T cells shared similar phenotypic markers, and were positively correlated in frequency with, splenic follicular T helper cells. Conclusion: Circulating CXCR5(+)CD4(+) T cells, by producing IL-21, may have a significant role in facilitating HBeAg seroconversion in patients with chronic HBV infection. (Hepatology 2013;58:1277-1286)

语种: 英语
所属项目编号: 2012ZX10002-003 ; 2011CB946100 ; 30830091 ; 81270025
项目资助者: Major Science and Technology Special Project of China ; Natural Science Foundation of China
WOS记录号: WOS:000325150100014
Citation statistics:
内容类型: 期刊论文
版本: 出版稿
URI标识: http://ir.bjmu.edu.cn/handle/400002259/67276
Appears in Collections:基础医学院_免疫学系_期刊论文

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作者单位: 1.Auckland City Hosp, Auckland, New Zealand
2.Univ Oxford, London, England
3.Novatis Pharma AG, Basel, Switzerland
4.Kunming Gen Hosp PLA, Dept Infect Dis, Kunming, Peoples R China
5.Southern Med Univ, Nanfang Hosp, Dept Infect Dis, Guangzhou 510515, Guangdong, Peoples R China
6.Southern Med Univ, Nanfang Hosp, Hepatol Unit, Guangzhou 510515, Guangdong, Peoples R China
7.Peking Univ, Hlth Sci Ctr, Dept Immunol, Beijing 100191, Peoples R China

Recommended Citation:
Li, Yongyin,Ma, Shiwu,Tang, Libo,et al. Circulating Chemokine (C-X-C Motif) Receptor 5(+)CD4(+) T Cells Benefit Hepatitis B e Antigen Seroconversion Through IL-21 in Patients With Chronic Hepatitis B Virus Infection[J]. HEPATOLOGY,2013,58(4):1277-1286.
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