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学科主题: 口腔医学
题名:
Antibiotic-decorated titanium with enhanced antibacterial activity through adhesive polydopamine for dental/bone implant
作者: He, Shu1; Zhou, Ping3; Wang, Linxin4; Xiong, Xiaoling1; Zhang, Yifei2; Deng, Yi3; Wei, Shicheng1,3
关键词: polydopamine ; titanium ; antibiotic ; antibacterial activity ; implant
刊名: JOURNAL OF THE ROYAL SOCIETY INTERFACE
发表日期: 2014-06-06
DOI: 10.1098/rsif.2014.0169
卷: 11, 期:95
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Multidisciplinary Sciences
研究领域[WOS]: Science & Technology - Other Topics
关键词[WOS]: SURFACE MODIFICATION ; CEFOTAXIME SODIUM ; PROTEUS-MIRABILIS ; IN-VIVO ; OSTEOGENIC DIFFERENTIATION ; BIOFILM FORMATION ; ESCHERICHIA-COLI ; POLYMER SURFACES ; STEM-CELLS ; COATINGS
英文摘要:

Implant-associated infections, which are normally induced by microbial adhesion and subsequent biofilm formation, are a major cause of morbidity and mortality. Therefore, practical approaches to prevent implant-associated infections are in great demand. Inspired by adhesive proteins in mussels, here we have developed a novel antibiotic-decorated titanium (Ti) material with enhanced antibacterial activity. In this study, Ti substrate was coated by one-step pH-induced polymerization of dopamine followed by immobilization of the antibiotic cefotaxime sodium (CS) onto the polydopamine-coated Ti through catechol chemistry. Contact angle measurement and X-ray photoelectron spectroscopy confirmed the presence of CS grafted on the Ti surface. Our results demonstrated that the antibiotic-grafted Ti substrate showed good biocompatibility and well-behaved haemocompatibility. In addition, the antibiotic- grafted Ti could effectively prevent adhesion and proliferation of Escherichia coli (Gram-negative) and Streptococcus mutans (Gram-positive). Moreover, the inhibition of biofilm formation on the antibiotic-decorated Ti indicated that the grafted CS could maintain its long-term antibacterial activity. This modified Ti substrate with enhanced antibacterial activity holds great potential as implant material for applications in dental and bone graft substitutes.

语种: 英语
所属项目编号: 30973317 ; 2007CB936103
项目资助者: National Natural Science Foundation of China ; State Key Development Programme for Basic Research of China ; Peking University&prime ; s 985 grant
WOS记录号: WOS:000335639900029
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/67280
Appears in Collections:北京大学口腔医学院_口腔颌面外科_期刊论文

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作者单位: 1.Peking Univ, Lab Interdisciplinary Studies, Dept Oral & Maxillofacial Surg, Beijing 100081, Peoples R China
2.Peking Univ, Cent Lab, Sch & Hosp Stomatol, Beijing 100081, Peoples R China
3.Peking Univ, Acad Adv Interdisciplinary Studies, Ctr Biomed Mat & Tissue Engn, Beijing 100871, Peoples R China
4.Capital Med Univ, Beijing Shijitan Hosp, Dept Stomatol, Beijing 100038, Peoples R China

Recommended Citation:
He, Shu,Zhou, Ping,Wang, Linxin,et al. Antibiotic-decorated titanium with enhanced antibacterial activity through adhesive polydopamine for dental/bone implant[J]. JOURNAL OF THE ROYAL SOCIETY INTERFACE,2014,11(95).
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