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The important anti-apoptotic role and its regulation mechanism of PTTG1 in UV-Induced apoptosis
Lai, Yongqing; Xin, Dianqi; Bai, Junhai; Mao, Zebin; Na, Yanqun
关键词apoptosis jun n-terminal kinases pituitary tumor transforming gene 1 PTTG1 UV
刊名JOURNAL OF BIOCHEMISTRY AND MOLECULAR BIOLOGY
2007-11-30
40期:6页:966-972
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biochemistry & Molecular Biology
研究领域[WOS]Biochemistry & Molecular Biology
关键词[WOS]TUMOR-TRANSFORMING GENE ; DIFFERENTIATED THYROID-CANCER ; PITUITARY-ADENOMAS ; BREAST-CANCER ; EXPRESSION ; PROTEIN ; CELLS ; TUMORIGENESIS ; HPTTG ; IDENTIFICATION
英文摘要

Pituitary tumor transforming gene (PTTG1) is widely detected in many tumors. Increasing evidence reveals that PTTG1 is associated with cell proliferation, cellular transformation and apoptosis. However, the functions of PTTG1, especially its role in DNA damage-induced apoptosis, remain largely unclear. In this report, we used IN irradiation to induce apoptosis in HeLa cells to examine the role of PTTG1 in UV-induced apoptosis by RNAi-mediated knockdown and overexpression of PTTG1. RNAi-mediated knockdown of PTTG1 expression increased and overexpression of PTTG1 decreased the UV-induced apoptosis. Furthermore, UV irradiation decreased PTTG1 mRNA and protein expression. These effects were found to be mediated by JNK pathway. Therefore, PTTG1 had an important anti-apoptotic role in UV-induced apoptosis and this role was mediated by JNK pathway. These results may provide important information for understanding the exact role and the regulation mechanism of PTTG1 in UV-induced apoptosis.

语种英语
WOS记录号WOS:000251141900017
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被引频次:12[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/67284
专题北京大学第一临床医学院_泌尿外科
作者单位1.Peking Univ, Peking Univ First Hosp, Inst Urol, Dept Urol, Beijing 100034, Peoples R China
2.Peking Univ, Hlth Sci Ctr, Dept Biochem & Mol Biol, Beijing 100083, Peoples R China
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GB/T 7714
Lai, Yongqing,Xin, Dianqi,Bai, Junhai,et al. The important anti-apoptotic role and its regulation mechanism of PTTG1 in UV-Induced apoptosis[J]. JOURNAL OF BIOCHEMISTRY AND MOLECULAR BIOLOGY,2007,40(6):966-972.
APA Lai, Yongqing,Xin, Dianqi,Bai, Junhai,Mao, Zebin,&Na, Yanqun.(2007).The important anti-apoptotic role and its regulation mechanism of PTTG1 in UV-Induced apoptosis.JOURNAL OF BIOCHEMISTRY AND MOLECULAR BIOLOGY,40(6),966-972.
MLA Lai, Yongqing,et al."The important anti-apoptotic role and its regulation mechanism of PTTG1 in UV-Induced apoptosis".JOURNAL OF BIOCHEMISTRY AND MOLECULAR BIOLOGY 40.6(2007):966-972.
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