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学科主题: 临床医学
题名:
The important anti-apoptotic role and its regulation mechanism of PTTG1 in UV-Induced apoptosis
作者: Lai, Yongqing; Xin, Dianqi; Bai, Junhai; Mao, Zebin; Na, Yanqun
关键词: apoptosis ; jun n-terminal kinases ; pituitary tumor transforming gene 1 ; PTTG1 ; UV
刊名: JOURNAL OF BIOCHEMISTRY AND MOLECULAR BIOLOGY
发表日期: 2007-11-30
卷: 40, 期:6, 页:966-972
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Biochemistry & Molecular Biology
研究领域[WOS]: Biochemistry & Molecular Biology
关键词[WOS]: TUMOR-TRANSFORMING GENE ; DIFFERENTIATED THYROID-CANCER ; PITUITARY-ADENOMAS ; BREAST-CANCER ; EXPRESSION ; PROTEIN ; CELLS ; TUMORIGENESIS ; HPTTG ; IDENTIFICATION
英文摘要:

Pituitary tumor transforming gene (PTTG1) is widely detected in many tumors. Increasing evidence reveals that PTTG1 is associated with cell proliferation, cellular transformation and apoptosis. However, the functions of PTTG1, especially its role in DNA damage-induced apoptosis, remain largely unclear. In this report, we used IN irradiation to induce apoptosis in HeLa cells to examine the role of PTTG1 in UV-induced apoptosis by RNAi-mediated knockdown and overexpression of PTTG1. RNAi-mediated knockdown of PTTG1 expression increased and overexpression of PTTG1 decreased the UV-induced apoptosis. Furthermore, UV irradiation decreased PTTG1 mRNA and protein expression. These effects were found to be mediated by JNK pathway. Therefore, PTTG1 had an important anti-apoptotic role in UV-induced apoptosis and this role was mediated by JNK pathway. These results may provide important information for understanding the exact role and the regulation mechanism of PTTG1 in UV-induced apoptosis.

语种: 英语
WOS记录号: WOS:000251141900017
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/67284
Appears in Collections:北京大学第一临床医学院_泌尿外科_期刊论文

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作者单位: 1.Peking Univ, Peking Univ First Hosp, Inst Urol, Dept Urol, Beijing 100034, Peoples R China
2.Peking Univ, Hlth Sci Ctr, Dept Biochem & Mol Biol, Beijing 100083, Peoples R China

Recommended Citation:
Lai, Yongqing,Xin, Dianqi,Bai, Junhai,et al. The important anti-apoptotic role and its regulation mechanism of PTTG1 in UV-Induced apoptosis[J]. JOURNAL OF BIOCHEMISTRY AND MOLECULAR BIOLOGY,2007,40(6):966-972.
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