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Studies on the drug-loading mechanism of polybutylcyanocrylate nanoparticle and its stability of thermodynamics
Zhang Xue-Nong1; Gong Jing-Hong1; Tang Li-Hua1; Zhang Qiang2
关键词albendazole nanoparticle load-drug mechanism stability
刊名CURRENT NANOSCIENCE
2008-02-01
4期:1页:59-61
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biotechnology & Applied Microbiology ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary
研究领域[WOS]Biotechnology & Applied Microbiology ; Science & Technology - Other Topics ; Materials Science
关键词[WOS]ECHINOCOCCOSIS ; ALBENDAZOLE ; ADSORPTION ; TISSUE
英文摘要

Aim of this paper is to study the load-drug mechanism of polybutylcyanocrylate nanoparticles and the physical stability of albendazole-polybutylcyanocrylate nanoparticle (ABZ-PBCA-NP). The adsorption mechanism between albendazole with polybutylcyanocrylate nanoparticle in different phosphate buffer solution (PBS) were investigated with isothermadsorption method. The constants of stability constants of albendazole-loading nanoparticles were predicted by determined the conductance rate of nanoparticles colloid under predetermined temperature in interval time. At the same time, several stabilizer including polyvinyl pyrrolidone (PVP), carboxymethylcellulose sodium (CMC-Na) and hydroxoy-propyl methyl cellulose (HPMC) was screen for improving stability and fluidity of nanoparticle suspension. The results showed that the mechanism of drug-load in nanoparticle was fitted the Langmuir equation. The conductance rate indicated that load-drug nanoparticle in suspension was unstability due to nature aggregation tendency and improved by reinforced with 4% PVP in solution.

语种英语
WOS记录号WOS:000254019100006
引用统计
被引频次:9[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/67286
专题北京大学药学院_药剂学系
作者单位1.Soochow Univ, Coll Pharm, Suzhou 215123, Jiang Su Prov, Peoples R China
2.Peking Univ, Sch Pharmaceut Sci, Dept Pharmaceut, Beijing 100083, Peoples R China
推荐引用方式
GB/T 7714
Zhang Xue-Nong,Gong Jing-Hong,Tang Li-Hua,et al. Studies on the drug-loading mechanism of polybutylcyanocrylate nanoparticle and its stability of thermodynamics[J]. CURRENT NANOSCIENCE,2008,4(1):59-61.
APA Zhang Xue-Nong,Gong Jing-Hong,Tang Li-Hua,&Zhang Qiang.(2008).Studies on the drug-loading mechanism of polybutylcyanocrylate nanoparticle and its stability of thermodynamics.CURRENT NANOSCIENCE,4(1),59-61.
MLA Zhang Xue-Nong,et al."Studies on the drug-loading mechanism of polybutylcyanocrylate nanoparticle and its stability of thermodynamics".CURRENT NANOSCIENCE 4.1(2008):59-61.
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