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学科主题: 基础医学
题名:
Analysis of the chemotactic activities of mouse chemokine MIP-2 to thymocyte subgroups
作者: Gong, SY; Gao, L; Qian, XP; Tian, T; Chen, WF
关键词: macrophage inflamatory protein 2 ; thymocytes ; chemotactic activity
刊名: CHINESE SCIENCE BULLETIN
发表日期: 2001-10-01
卷: 46, 期:20, 页:1694-1698
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Multidisciplinary Sciences
研究领域[WOS]: Science & Technology - Other Topics
关键词[WOS]: RECEPTOR ; CLONING ; THYMUS ; CELLS ; CDNA
英文摘要:

A mouse chemokine MIP-2 (macrophage inflamatory protein 2) is constitutively expressed not only by peritoneal. macrophages, but also by fresh thymic stromal cells, based on RT-PCR detection. Moreover, the specific receptor of MIP-2 is expressed at different levels among four main subgroups of murine thymocytes including DN, DP, CD4SP and CD8SP. By the chemotaxis assays with Boyden chamber, we proved that the recombinant mouse MIP-2 can chemoattract the four main subgroups of thymocytes, in different degrees, it mainly chemoattract the, DP and SP subgroups. We firstly reported that MIP-2 is involved in the regulation of the directional migration of developing thymocytes.

语种: 英语
WOS记录号: WOS:000172304000006
Citation statistics:
内容类型: 期刊论文
版本: 出版稿
URI标识: http://ir.bjmu.edu.cn/handle/400002259/67298
Appears in Collections:基础医学院_免疫学系_期刊论文

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作者单位: Peking Univ, Hlth Sci Ctr, Dept Immunol, Beijing 100083, Peoples R China

Recommended Citation:
Gong, SY,Gao, L,Qian, XP,et al. Analysis of the chemotactic activities of mouse chemokine MIP-2 to thymocyte subgroups[J]. CHINESE SCIENCE BULLETIN,2001,46(20):1694-1698.
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