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学科主题基础医学
Analysis of the chemotactic activities of mouse chemokine MIP-2 to thymocyte subgroups
Gong, SY; Gao, L; Qian, XP; Tian, T; Chen, WF
关键词macrophage inflamatory protein 2 thymocytes chemotactic activity
刊名CHINESE SCIENCE BULLETIN
2001-10-01
46期:20页:1694-1698
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Multidisciplinary Sciences
研究领域[WOS]Science & Technology - Other Topics
关键词[WOS]RECEPTOR ; CLONING ; THYMUS ; CELLS ; CDNA
英文摘要

A mouse chemokine MIP-2 (macrophage inflamatory protein 2) is constitutively expressed not only by peritoneal. macrophages, but also by fresh thymic stromal cells, based on RT-PCR detection. Moreover, the specific receptor of MIP-2 is expressed at different levels among four main subgroups of murine thymocytes including DN, DP, CD4SP and CD8SP. By the chemotaxis assays with Boyden chamber, we proved that the recombinant mouse MIP-2 can chemoattract the four main subgroups of thymocytes, in different degrees, it mainly chemoattract the, DP and SP subgroups. We firstly reported that MIP-2 is involved in the regulation of the directional migration of developing thymocytes.

语种英语
WOS记录号WOS:000172304000006
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文献类型期刊论文
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条目标识符http://ir.bjmu.edu.cn/handle/400002259/67298
专题北京大学基础医学院_免疫学系
作者单位Peking Univ, Hlth Sci Ctr, Dept Immunol, Beijing 100083, Peoples R China
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GB/T 7714
Gong, SY,Gao, L,Qian, XP,et al. Analysis of the chemotactic activities of mouse chemokine MIP-2 to thymocyte subgroups[J]. CHINESE SCIENCE BULLETIN,2001,46(20):1694-1698.
APA Gong, SY,Gao, L,Qian, XP,Tian, T,&Chen, WF.(2001).Analysis of the chemotactic activities of mouse chemokine MIP-2 to thymocyte subgroups.CHINESE SCIENCE BULLETIN,46(20),1694-1698.
MLA Gong, SY,et al."Analysis of the chemotactic activities of mouse chemokine MIP-2 to thymocyte subgroups".CHINESE SCIENCE BULLETIN 46.20(2001):1694-1698.
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