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学科主题: 公共卫生
题名:
Effects of folinic acid and Vitamin B-12 on ethanol-induced developmental toxicity in mouse
作者: Xu, Yajun; Li, Li; Zhang, Zhaofeng; Li, Yong
关键词: ethanol ; folinic acid ; vitamin B-12 ; developmental toxicity
刊名: TOXICOLOGY LETTERS
发表日期: 2006-12-15
DOI: 10.1016/j.toxlet.2006.07.341
卷: 167, 期:3, 页:167-172
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Toxicology
研究领域[WOS]: Toxicology
关键词[WOS]: FETAL-ALCOHOL-SYNDROME ; NEURAL-TUBE DEFECTS ; RAT EMBRYOS ; FOLATE-DEFICIENCY ; PREVENTION ; PREGNANCY ; SUPPLEMENTATION ; EXPRESSION ; CULTURE
英文摘要:

The objective of this study was to assess whether combined supplementation of folinic acid (FA) and Vitamin B-12 (VB12) could suppress ethanol-induced developmental toxicity better than FA alone in mouse embryos cultured in vitro. In this study, exposure to 4.0 mg/ml ethanol for 48 h yielded growth retardation and various malformations of the embryos. FA (10(-5), 10(-4) Mol/l) or VB12 (10(-6), 10(-5) mol/l) alone supplementation improved the growth parameters moderately, however combined supplementation of the two vitamins (10(-5) mol/l FA plus 10(-6) mol/l VB12, 10(-5) mol/l FA plus 10(-5) mol/l VB12, 10(-4) mol/l FA plus 10(-6) Mol/l VB12 and 10(-4) mol/l FA plus 10(-5) mol/l VB12) showed better protective effects, including both the growth and development parameters of the embryos, than either vitamin alone at the same dosage. The present investigation indicated that combined supplementation of folic acid and VB12 might be a better choice than folic acid alone in the prevention of ethanol-induced birth defects. (c) 2006 Elsevier Ireland Ltd. All rights reserved.

语种: 英语
WOS记录号: WOS:000243046300001
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/67318
Appears in Collections:北京大学公共卫生学院_期刊论文

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作者单位: Peking Univ, Sch Publ Hlth, Dept Nutr & Food Hyg, Lab Mol Toxicol & Dev Mol Biol, Beijing 100083, Peoples R China

Recommended Citation:
Xu, Yajun,Li, Li,Zhang, Zhaofeng,et al. Effects of folinic acid and Vitamin B-12 on ethanol-induced developmental toxicity in mouse[J]. TOXICOLOGY LETTERS,2006,167(3):167-172.
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