IR@PKUHSC  > 北京大学公共卫生学院
学科主题公共卫生
Effects of folinic acid and Vitamin B-12 on ethanol-induced developmental toxicity in mouse
Xu, Yajun; Li, Li; Zhang, Zhaofeng; Li, Yong
关键词ethanol folinic acid vitamin B-12 developmental toxicity
刊名TOXICOLOGY LETTERS
2006-12-15
DOI10.1016/j.toxlet.2006.07.341
167期:3页:167-172
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Toxicology
研究领域[WOS]Toxicology
关键词[WOS]FETAL-ALCOHOL-SYNDROME ; NEURAL-TUBE DEFECTS ; RAT EMBRYOS ; FOLATE-DEFICIENCY ; PREVENTION ; PREGNANCY ; SUPPLEMENTATION ; EXPRESSION ; CULTURE
英文摘要

The objective of this study was to assess whether combined supplementation of folinic acid (FA) and Vitamin B-12 (VB12) could suppress ethanol-induced developmental toxicity better than FA alone in mouse embryos cultured in vitro. In this study, exposure to 4.0 mg/ml ethanol for 48 h yielded growth retardation and various malformations of the embryos. FA (10(-5), 10(-4) Mol/l) or VB12 (10(-6), 10(-5) mol/l) alone supplementation improved the growth parameters moderately, however combined supplementation of the two vitamins (10(-5) mol/l FA plus 10(-6) mol/l VB12, 10(-5) mol/l FA plus 10(-5) mol/l VB12, 10(-4) mol/l FA plus 10(-6) Mol/l VB12 and 10(-4) mol/l FA plus 10(-5) mol/l VB12) showed better protective effects, including both the growth and development parameters of the embryos, than either vitamin alone at the same dosage. The present investigation indicated that combined supplementation of folic acid and VB12 might be a better choice than folic acid alone in the prevention of ethanol-induced birth defects. (c) 2006 Elsevier Ireland Ltd. All rights reserved.

语种英语
WOS记录号WOS:000243046300001
引用统计
被引频次:10[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/67318
专题北京大学公共卫生学院
作者单位Peking Univ, Sch Publ Hlth, Dept Nutr & Food Hyg, Lab Mol Toxicol & Dev Mol Biol, Beijing 100083, Peoples R China
推荐引用方式
GB/T 7714
Xu, Yajun,Li, Li,Zhang, Zhaofeng,et al. Effects of folinic acid and Vitamin B-12 on ethanol-induced developmental toxicity in mouse[J]. TOXICOLOGY LETTERS,2006,167(3):167-172.
APA Xu, Yajun,Li, Li,Zhang, Zhaofeng,&Li, Yong.(2006).Effects of folinic acid and Vitamin B-12 on ethanol-induced developmental toxicity in mouse.TOXICOLOGY LETTERS,167(3),167-172.
MLA Xu, Yajun,et al."Effects of folinic acid and Vitamin B-12 on ethanol-induced developmental toxicity in mouse".TOXICOLOGY LETTERS 167.3(2006):167-172.
条目包含的文件
条目无相关文件。
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Xu, Yajun]的文章
[Li, Li]的文章
[Zhang, Zhaofeng]的文章
百度学术
百度学术中相似的文章
[Xu, Yajun]的文章
[Li, Li]的文章
[Zhang, Zhaofeng]的文章
必应学术
必应学术中相似的文章
[Xu, Yajun]的文章
[Li, Li]的文章
[Zhang, Zhaofeng]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。