IR@PKUHSC  > 北京大学第三临床医学院
学科主题临床医学
LPR: How Different Diagnostic Tools Shape the Outcomes of Treatment
Wan, Yichen1,2; Yan, Yan1; Ma, Furong1; Wang, Li1; Lu, Peiquan1; Maytag, Allison3; Jiang, Jack J.3
关键词Laryngopharyngeal reflux RSI RSF 24-Hour multichannel intraluminal impedance pH monitoring
刊名JOURNAL OF VOICE
2014-05-01
DOI10.1016/j.jvoice.2013.12.004
28期:3
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Otorhinolaryngology
研究领域[WOS]Otorhinolaryngology
关键词[WOS]PROTON PUMP INHIBITORS ; LARYNGOPHARYNGEAL REFLUX ; LARYNGITIS ; THERAPY ; TRIAL ; QUESTIONS ; DISEASE
英文摘要

Objective. To seek a deeper and more comprehensive understanding of two major diagnostic methods for laryngopharyngeal reflux by exploring whether and how differences exist before and after treatment between patients diagnosed by either Reflux Symptom Index (RSI) and Reflux Finding Score (RFS) or 24-hour pH monitoring.

Materials and Methods. Two groups of patients who confirmed laryngopharyngeal reflux disease (LPRD) by either a combination of RSI and RFS (Questionnaire group, 35 patients) or 24-hour multichannel intraluminal impedance (MII) pH monitoring (pH Group, 23 patients) were recruited. All patients were prescribed esomeprazole 20 mg twice a day for 1 month. RSI, RFS, and acoustic parameters before and after treatment were compared between the two groups. Intrinsic correlations involving multiple parameters were investigated as well.

Results. Except for excess throat mucus (P = 0.019) and subglottic edema (P = 0.042), most RSI and RFS items before treatment were not significantly different between the Questionnaire and pH Groups, and nearly all such items in both groups exhibited distinct remission after therapy (P < 0.05). Absolute value of remission in RSI after treatment was more prominent in pH Group than in the Questionnaire group (P = 0.007). Jitter (P = 0.252), shimmer (P = 0.815), and harmonics-to-noise ratio (P = 0.117) descended to normal value after treatment. Moderate to high levels of correlation were found between the patient′s original status and the absolute value of remission in most items of RSI and RFS as well as voice parameters.

Conclusion. The 24-hour MII pH monitoring and a combination of RSI and RFS are quite competitive with each other in selecting LPRD patients. Although treatment worked out on nearly all the symptoms, laryngeal images and voice parameters, 24-hour MII pH seems to be more promising in a greater symptom relief. The extent of relief that can take place in most of the measurements is considerably determined by their initial status.

语种英语
WOS记录号WOS:000335442600016
引用统计
被引频次:8[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/67321
专题北京大学第三临床医学院
作者单位1.Peking Univ, Hosp 3, Dept Otolaryngol Head & Neck Surg, Beijing 100871, Peoples R China
2.Peking Univ, Int Hosp, Dept Otolaryngol Head & Neck Surg, Beijing 100871, Peoples R China
3.Univ Wisconsin, Dept Surg, Sch Med & Publ Hlth, Div Otolaryngol Head & Neck Surg, Madison, WI USA
推荐引用方式
GB/T 7714
Wan, Yichen,Yan, Yan,Ma, Furong,et al. LPR: How Different Diagnostic Tools Shape the Outcomes of Treatment[J]. JOURNAL OF VOICE,2014,28(3).
APA Wan, Yichen.,Yan, Yan.,Ma, Furong.,Wang, Li.,Lu, Peiquan.,...&Jiang, Jack J..(2014).LPR: How Different Diagnostic Tools Shape the Outcomes of Treatment.JOURNAL OF VOICE,28(3).
MLA Wan, Yichen,et al."LPR: How Different Diagnostic Tools Shape the Outcomes of Treatment".JOURNAL OF VOICE 28.3(2014).
条目包含的文件
条目无相关文件。
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Wan, Yichen]的文章
[Yan, Yan]的文章
[Ma, Furong]的文章
百度学术
百度学术中相似的文章
[Wan, Yichen]的文章
[Yan, Yan]的文章
[Ma, Furong]的文章
必应学术
必应学术中相似的文章
[Wan, Yichen]的文章
[Yan, Yan]的文章
[Ma, Furong]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。