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学科主题: 临床医学
题名:
LPR: How Different Diagnostic Tools Shape the Outcomes of Treatment
作者: Wan, Yichen1,2; Yan, Yan1; Ma, Furong1; Wang, Li1; Lu, Peiquan1; Maytag, Allison3; Jiang, Jack J.3
关键词: Laryngopharyngeal reflux ; RSI ; RSF ; 24-Hour multichannel intraluminal impedance pH monitoring
刊名: JOURNAL OF VOICE
发表日期: 2014-05-01
DOI: 10.1016/j.jvoice.2013.12.004
卷: 28, 期:3
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Otorhinolaryngology
研究领域[WOS]: Otorhinolaryngology
关键词[WOS]: PROTON PUMP INHIBITORS ; LARYNGOPHARYNGEAL REFLUX ; LARYNGITIS ; THERAPY ; TRIAL ; QUESTIONS ; DISEASE
英文摘要:

Objective. To seek a deeper and more comprehensive understanding of two major diagnostic methods for laryngopharyngeal reflux by exploring whether and how differences exist before and after treatment between patients diagnosed by either Reflux Symptom Index (RSI) and Reflux Finding Score (RFS) or 24-hour pH monitoring.

Materials and Methods. Two groups of patients who confirmed laryngopharyngeal reflux disease (LPRD) by either a combination of RSI and RFS (Questionnaire group, 35 patients) or 24-hour multichannel intraluminal impedance (MII) pH monitoring (pH Group, 23 patients) were recruited. All patients were prescribed esomeprazole 20 mg twice a day for 1 month. RSI, RFS, and acoustic parameters before and after treatment were compared between the two groups. Intrinsic correlations involving multiple parameters were investigated as well.

Results. Except for excess throat mucus (P = 0.019) and subglottic edema (P = 0.042), most RSI and RFS items before treatment were not significantly different between the Questionnaire and pH Groups, and nearly all such items in both groups exhibited distinct remission after therapy (P < 0.05). Absolute value of remission in RSI after treatment was more prominent in pH Group than in the Questionnaire group (P = 0.007). Jitter (P = 0.252), shimmer (P = 0.815), and harmonics-to-noise ratio (P = 0.117) descended to normal value after treatment. Moderate to high levels of correlation were found between the patient′s original status and the absolute value of remission in most items of RSI and RFS as well as voice parameters.

Conclusion. The 24-hour MII pH monitoring and a combination of RSI and RFS are quite competitive with each other in selecting LPRD patients. Although treatment worked out on nearly all the symptoms, laryngeal images and voice parameters, 24-hour MII pH seems to be more promising in a greater symptom relief. The extent of relief that can take place in most of the measurements is considerably determined by their initial status.

语种: 英语
WOS记录号: WOS:000335442600016
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/67321
Appears in Collections:北京大学第三临床医学院_期刊论文

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作者单位: 1.Peking Univ, Hosp 3, Dept Otolaryngol Head & Neck Surg, Beijing 100871, Peoples R China
2.Peking Univ, Int Hosp, Dept Otolaryngol Head & Neck Surg, Beijing 100871, Peoples R China
3.Univ Wisconsin, Dept Surg, Sch Med & Publ Hlth, Div Otolaryngol Head & Neck Surg, Madison, WI USA

Recommended Citation:
Wan, Yichen,Yan, Yan,Ma, Furong,et al. LPR: How Different Diagnostic Tools Shape the Outcomes of Treatment[J]. JOURNAL OF VOICE,2014,28(3).
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